Creatine kinase transition state structure

Figure 12-19 Proposed transition state structure formed from Mn2+i ATP, and creatine bound in the active site of muscle creatine kinase. Based on EPR spectroscopy with regiospecifically 170-labeled substrates. The electrical charges have been added in one possible constellation. However, hydrogen atoms bound to phospho groups are not shown. After Leyh et al.68i...

Figure 4.. Possible structure of the transition state for phos-phoryl transfer in the creatine kinase reaction. Adapted from Cook et al(95).

K.N. The 2.1 A structure of Torpedo californica creatine kinase complexed with the ADP-Mg -NOj-creatine transition-state analogue complex. Biochemistry, 41, 13861-13867 (2002)... 

Fig. 5. Proposed structure of the abortive quaternary nitrate complex of creatine kinase (55) which may mimic the transition state of the enzymatic reaction, based on kinetic (54), EPR (55) and nuclear relaxation studies (88)...

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