Adenosine triphosphate-creatine phosphotransferase

Simonarson, B. Watts, D.C. Purification and properties of adenosine triphosphate-creatine phosphotransferase from muscle of the dogfish Scyl-liorhinus canicula. Biochem. J., 128, 1241-1253 (1972)... 

Creatine Kinase (Adenosine 5 -Triphosphate-Creatine Phosphotransferase)... 

Adenosine triphosphate creatine A-phosphotransferase (EC 2.7.3.2), also creatine phosphokinase. Creatine kinase is found in muscle and is responsible for the formation of creatine phosphate from creatine and adenosine triphosphate creatine phosphate is a higher energy source for muscle contraction. Creatine kinase is elevated in all forms of muscular dystrophy. Creatine kinase is dimer and is present as isozymes (CK-1, BB CK-2, MB CK-3, MM) and Ck-mt (mitochondrial). Creatine kinase is also used to measure cardiac muscle damage in myocardial infarction. See Bais, R. and Edwards, J.B., Creatine kinase, CRC Crit. Rev. Clin. Lab. ScL 16, 291-355, 1982 McLeish, M.J. and Kenyon, G.L., Relating structure to mechanism in creatine kinase, Crit. Rev. Biochem. Mol. Biol 40, 1-20, 2005. 

CK (EC 2.7.3.2 adenosine triphosphate creatine N-phosphotransferase CK) is a dimeric enzyme (82kDa) that catalyzes the reversible phosphorylation of creatine (Cr) by adenosine triphosphate (ATP). 

H8. Hooton, B. T., and Watts, D. C., Adenosine 5 -triphosphate-creatine phosphotransferase from dystrophic mouse skeletal muscle. A genetic lesion associated with the catalytic-site thiol group. Biochem. J. 100, 637-646 (1966). 

Creatine kinase, CK (or creatine phosphotransferase, E.C. 2.7.3.2) is an important enzyme in our body involved in energy transfer in muscle. Specifically, the enzyme catalyzes phosphate transfer from creatine phosphate, CrP, to Mg -coordinated adenosine diphosphate, MgADP, to create adenosine triphosphate, ATP, according to the scheme in Fig. 10.3. 

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