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Coupling compounds

The technically most significant groups of coupling compounds are a) Compounds containing activated methylene groups of the type [Pg.188]

The reaction may proceed in water, acetic acid, or any other organic solvent or mixture that is inert to diketene. This group also includes bifunctional coupling components of the bisacetoacetic diaminodiphenyl type  [Pg.189]

Supplement to b) 2-Hydroxynaphthalene ((3-naphthol) is obtained from naphthalene. The reaction sequence includes sulfonation of the starting material at 150-160°C and subsequent alkaline baking of the intermediate sodium naphthalene-2-sulfonate with sodium hydroxide at 300 to 320°C for 6 to 8 hours. After the reac- [Pg.189]

2-Hydroxy-3-naphthoic acid ( BONA or BON ) is prepared by heating the sodium salt of 2-hydroxynaphthalene with carbon dioxide in a pressure chamber at 240 to 250°C at a pressure of 15 bar (Kolbe synthesis). The reaction mixture is continuously agitated. Remaining 2-naphthol is separated and recycled  [Pg.190]

The formation of the technically important 2 -hydroxy-3 -naphthoylanilines (Naphthol AS derivatives) is accomplished primarily by a condensation reaction between 2-hydroxy-3-naphthoic acid and an aromatic amine in the presence of phosphorus trichloride at 70 to 80°C. Appropriate reaction media are organic solvents, such as toluene or xylene. In stoichiometric terms, one mole of 2-hydroxy-3-naphthoic acid reacts with 0.4 to 0.5 moles of phosphorus trichloride. The solution is allowed to cool to room temperature, then neutralized with a sodium carbonate solution, and the Naphthol AS derivative is isolated by filtration. Mechanistically, the reaction is thought to proceed via the phosphoazo compound (11)  [Pg.190]


Table 1. Dyes Derived from Tetrazotized (7) Dye or Coupling Compound... Table 1. Dyes Derived from Tetrazotized (7) Dye or Coupling Compound...
Azo coupling reactions are often used for quantitative determination of trace compounds, e. g., for nitrous acid and for compounds that are either diazo or coupling compounds. Spectrophotometric determination of azo dyes formed from these compounds is possible down to concentrations of about 0.01 pg/mL. (An example is the determination of 4-aminophenazone by azo coupling with 4-nitrobenzenediazonium ions see Alwehaid, 1990.)... [Pg.332]

A (1 — SO-coupled compound between methyl (3/ )-3-[(3 / )-3 -hydroxy-decanoyloxy]decanoate and 2-0-a-L-rhamnopyranosyl-o -L-rhamnopyra-nose, a rhamnolipid from Pseudomonas aeruginosa, expected to have various biological activities, was prepared by double couplings using 3,4-di-0-benzyl-2-0-chloroacetyl-a-L-rhamnopyranosyl fluoride (by the BFj- OEtj method). [Pg.116]

Friedrichsen, G. M., Jacobsen, P., Taub, M. E., Begtrup, M., Application of enzymatically stable dipeptides for enhancement of intestinal permeability. Synthesis and in vitro evaluation of dipeptide-coupled compounds, Bioorg. Med. Chem. 2001, 9, 2625-2632. [Pg.544]

Palladium(0) converts symmetrical and unsymmetrical tellurides into coupled compounds under mild conditions. ... [Pg.195]

Cross coupling between an aryl halide and an activated alkyl halide, catalysed by the nickel system, is achieved by controlling the rate of addition of the alkyl halide to the reaction mixture. When the aryl halide is present in excess, it reacts preferentially with the Ni(o) intermediate whereas the Ni(l) intermediate reacts more rapidly with an activated alkyl halide. Thus continuous slow addition of the alkyl halide to the electrochemical cell already charged with the aryl halide ensures that the alkyl-aryl coupled compound becomes the major product. Activated alkyl halides include benzyl chloride, a-chloroketones, a-chloroesters and amides, a-chloro-nitriles and vinyl chlorides [202, 203, 204], Asymmetric induction during the coupling step occurs with over 90 % distereomeric excess from reactions with amides such as 62, derived from enantiomerically pure (-)-ephedrine, even when 62 is a mixture of diastereoisomcrs prepared from a racemic a-chloroacid. Metiha-nolysis of the amide product affords the chiral ester 63 and chiral ephedrine is recoverable [205]. [Pg.140]

The cross-coupling compound was isolated from the crude product by silica gel column chromatography (hexane/ethyl acetate 94/6-88/12). (0.104g, 87% yield). [Pg.274]

For a ratio 8 we obtain only one coupled compound and a high yield of sec.butyl-thlolate (about 60% of the products formed). The coupled compound Is well defined and contains only one sulfur atom In the sulfur bridge. [Pg.494]

When 4 we obtain always the coupled compounds and only a small amount of thiolate. Let us remark that In both cases 8 and 4, all the sulfur has been incorporated. The average number of sulfur atoms is about x - 2.3 and we observe sulfur bridges containing 1, 2, and 3 atoms. [Pg.495]

For = 2 we observe that there are traces of sulfur unreacted we do not observe any thiolate formation but only coupled compounds with 3.6 average number of sulfur atoms in the bridge of the dlalkylpolysulfldes The number of sulfur atoms in the polysulfides varies from 1 to 4, and one observes even traces of a higher polysulfide. [Pg.495]

The results obtained are quite similar to those described above. For < 2, we observe high yields of coupled compounds (around 80%) and some thlolate formation. [Pg.498]

On the other hand, neither 123 nor 124 was utilized for alkaloid biosynthesis when one of phenolic hydroxyl groups was methylated. Thus, the two phenolic hydroxyl groups should remain unmethylated until after phenol oxidative coupling. Compound 125 is proposed to be the intermediate in which coupling takes place. [Pg.173]

Some natural compounds offer a chiral structural backbone that biases the outcome of the oxidative coupling of appended aryls (e.g., the ellagitannins). It was plausible to suppose, therefore, that two aryl units could be linked by a non-natural chiral tether to induce atrop-selective coupling upon exposure to an appropriate oxidant. In one of their attempts to realize the total synthesis of calphostin D (200) [136], Merlic and co-workers showed that, in the presence of dioxygen in trifluoroacetic acid (TFA), the precursor 198 affords the coupled compound 199 as a single diastereoisomer. Unfortunately, the relative configuration was incorrect for the calphostin target (Scheme 49). [Pg.523]

Amhold J, Furtmuller PG, Regelsberger G et al (2001) Redox properties of the couple compound I/native enzyme of myeloperoxidase and eosinophil peroxidase. Eur J Biochem 268 5142-5148... [Pg.76]

Furtmuller PG, Amhold J, Jantschko W et al (2003) Redox properties of the couples compound I/compound II and compound II/native enzyme of human myeloperoxidase. Biochem Biophys Res Commun 301 551-557... [Pg.76]

As stated previously this weak spin/spin interaction is characteristic of biological ferryl iron coupled to a free radical. It is possible to synthesize porphyrin [129] and non-porphyrin [130] FeIV=0/radical model compounds that show evidence of much stronger coupling between the 5=1 (ferryl) and 5 = 1/2 (radical) states in the Mossbauer spectra. As stated previously (section 4.4) such strongly coupled compounds are EPR-active and have spectra characteristic of an 5 = 3/2 system, rather than a spin-broadened 5=1/2 free radical signal weakly coupled to an EPR-silent 5=1 state. [Pg.96]

FeCh-mediated oxidative cyclization of bis(thienyl) substituted compound 873 affords a—a. coupled product 874 (Equation 46) <2002JA7762> /3-/3 coupled compound 876 can be prepared from 875 <2006TL1551>. [Pg.919]


See other pages where Coupling compounds is mentioned: [Pg.296]    [Pg.189]    [Pg.49]    [Pg.87]    [Pg.333]    [Pg.15]    [Pg.188]    [Pg.189]    [Pg.191]    [Pg.212]    [Pg.136]    [Pg.143]    [Pg.12]    [Pg.125]    [Pg.104]    [Pg.469]    [Pg.5]    [Pg.19]    [Pg.256]    [Pg.500]    [Pg.205]    [Pg.349]    [Pg.120]    [Pg.44]    [Pg.441]    [Pg.441]    [Pg.116]    [Pg.245]    [Pg.183]    [Pg.1013]   
See also in sourсe #XX -- [ Pg.188 ]

See also in sourсe #XX -- [ Pg.908 ]




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1,2-diols reductive coupling of carbonyl compounds

1.2- Dicarbonyl compounds diazo-coupling reactions

13C NMR Chemical Shifts and Coupling Constants of Organometallic Compounds

Active methylene compounds coupling with

Active methylene compounds coupling with allylic

Active methylene compounds coupling with malonates

Alkenes reductive coupling with carbonyl compounds

Alkenyl halides, coupling with metals organometallic compounds from

Alkenyltin compounds coupling reactions

Allylic alcohols coupling with carbonyl compounds

Allyltin compounds coupling reactions

Amino compounds, acylation coupling

Aromatic compounds coupling

Aromatic compounds coupling constant

Aryl compounds Hiyama cross-coupling reaction

Aryl compounds Kumada cross-coupling reactions

Aryl compounds Negishi cross-coupling reactions

Aryl compounds crossed coupling reactions

Aryl compounds intramolecular coupling reactions

Aryl halides organometallic compound cross-coupling

Aryl-heteroaryl compounds, Suzuki coupling

Azo compounds demethylative coupling

Biaryl compounds, transition-metal-catalyzed cross-coupling

Boron compounds arylboron coupling

Boron compounds cross-coupling

Cadiot-Chodkiewicz coupling organocopper compounds

Carbonates, allylic, coupling compounds

Carbonyl compounds Julia coupling

Carbonyl compounds coupling

Carbonyl compounds intermolecular pinacol coupling reactions

Carbonyl compounds pinacol coupling reactions

Carbonyl compounds reductive coupling

Carbonyl compounds reductive coupling reactions

Carbonyl compounds reductive coupling with activated alkenes

Carbonyl compounds spin-orbit coupling

Copper® compounds Grignard couplings

Coupled cluster methods compounds

Coupling Agents used in Compounding

Coupling Compounds with Reactive Methylene

Coupling aromatic compounds, carbon hydrogen

Coupling constants ammonium compounds

Coupling constants compounds

Coupling of Activated Aliphatic Halides with Carbonyl Compounds

Coupling of Alkyl Iodides with a,-Unsaturated Compounds

Coupling of alkyl halides with organometallic compounds

Coupling of diazonium compound

Coupling of organozinc compounds

Coupling reactions Grignard compound

Coupling reactions aryl compounds

Coupling reactions compounds

Coupling reactions with aryl compounds

Coupling reactions with heteroaryl compounds

Cross-coupling allylic compounds

Cross-coupling compounds

Cross-coupling halides with organometallic compounds

Cross-coupling involving carbonyl compounds

Cross-coupling of haloalkynes with organometallic compounds

Cross-coupling organomagnesium compounds

Cross-coupling organomagnesium compounds with

Cross-coupling reactions 1 -alkynylboron compounds

Cross-coupling reactions of organoboron compounds

Cross-coupling reactions silicon compounds

Cross-coupling with organoboron compound

Cross-coupling with organotin compound

Diazo coupling, aromatic compounds

Diazonium compounds, coupling

Diazonium compounds, coupling detection

Diazonium salts coupling with aliphatic compounds

Diazonium salts, coupling compounds

Diazonium salts, coupling from aromatic compounds

Diazonium salts, coupling with aromatic compounds

Dicarbonyl compound, reductive coupling

Double Cross-coupling Reaction of Dimetal Compounds

Ei-ichi Negishi 2 Palladium-Catalyzed Cross-Coupling nvolving 3-Hetero-Substituted Compounds Other than Enolates

Enolate compounds carbon nucleophile coupling

Enolate compounds oxidative coupling

EtMgBr-iodoalkane-mediated Coupling of Arylmagnesium Compounds with Tetrahydrofuran via a Radical Process

Fen-Tair Luo 14 Palladium-Catalyzed Cross-Coupling Involving 3-Hetero-Substituted Compounds

Growth of the compound layer in various reaction couples short conclusions

Heteroaromatic compounds coupling reactions

Heteroaromatic compounds coupling with

Heteroaromatic compounds coupling with alkenes

Heteroaromatic compounds, Suzuki coupling

Heteroaromatic compounds, Suzuki coupling reactions

Heteroaryl compounds coupling reactions

Hydroxy compounds, acylation coupling

Intermolecular coupling aromatic compounds

Intramolecular Oxidative Coupling of Dimetal Compounds

Intramolecular coupling aromatic compounds

Lead compounds, quadrupole coupling

Lead compounds, quadrupole coupling constants

Ligand Coupling Reactions with Heteroatomic Compounds

Main group organometallic compounds cross-coupling

Mixed-valence compounds electronic coupling

Nitrogen compounds diazo coupling

One-Electron Reductions of Carbonyl Compounds and Esters Reductive Coupling

Organoaluminum compounds coupling

Organoboron compounds cross-coupling reactions

Organoboron compounds metal-catalyzed cross-coupling reactions, with organic

Organoboron compounds, Suzuki coupling

Organocopper compounds coupling

Organocopper compounds cross-coupling reactions

Organolithium compounds coupling with halides

Organomagnesium compounds Wurtz coupling

Organomagnesium compounds coupling reactions with alkenyl halides

Organometallic compound, coupling with

Organometallic compound, coupling with alkyl halide

Organometallic compounds acyl halide coupling

Organometallic compounds alkene coupling

Organometallic compounds carbon-metal couplings 293

Organometallic compounds coupling constants

Organometallic compounds coupling with active

Organometallic compounds coupling with alcohols

Organometallic compounds coupling with alkyl

Organometallic compounds cross-coupling

Organometallic compounds cross-coupling reactions

Organometallic compounds palladium coupling

Organometallic compounds palladium-catalyzed coupling

Organopalladium compounds coupling

Organosilicon Compounds (Hiyama Coupling)

Organosilicon compounds cross-coupling reactions

Organosodium compounds coupling

Organotin compounds coupling

Organotin compounds coupling reactions

Organotin compounds cross-coupling reactions

Organotin compounds, Stille coupling

Organotin compounds, cross-coupling

Organozinc Compounds (Negishi Coupling)

Organozinc compounds alkenylzinc coupling

Organozinc compounds arylzinc reagent coupling

Organozinc compounds coupling reactions

Organozinc compounds coupling reactions with alkenyl halides

Organozinc compounds cross-coupling

Organozinc compounds cross-coupling reactions

Organozinc compounds, coupling

Organozinc compounds, coupling with

Organozinc compounds, coupling with halides

Organozirconium compounds, cross-coupling

Organozirconium compounds, cross-coupling reactions

Oxidative Coupling of Arenes to Biaryl Compounds

Oxidative coupling of aromatic compounds

Palladium-catalysed cross-coupling of organotellurium compounds with hypervalent iodonium salts

Palladium-catalyzed cross coupling reaction of organoboron compounds

Palladium-catalyzed cross-coupling with compounds

Palladium-catalyzed cross-coupling with related compounds

Phosphonium coupling compounds

Pinacol coupling reactions organosamarium compounds

Pinacol coupling reactions with carbonyl compounds

Pinacolic coupling reactions organosamarium compounds

Proton hyperfine coupling, radical compound

Pyrrole direct coupling with carbonyl compounds

Quadrupole coupling constants transition metal compounds

Range Coupling in Aromatic Compounds

Reductive Coupling of Carbonyl-Containing Compounds and Imines Using Reactive Manganese

Reductive coupling of carbonyl compounds

Reductive cross-coupling compounds

Silane coupling agents compounds

Silicon compounds coupling reactions

Silicon-carbon compounds cross-coupling reactions

Single coupling reactions with hydroxy compounds

Sonogashira coupling reaction compounds

Suzuki cross-coupling reactions compounds

Synthesis of Carbazoles and Related Compounds via C—E Bond-Forming Coupling Reactions

Thiocarbonyl compounds coupling reactions

Three-component coupling of silyltellurides, carbonyl compounds and isocyanides

Titanium Compounds couple

Titanium compounds McMurry coupling

Titanium compounds use in intermolecular pinacol coupling reactions

Titanium compounds use in intramolecular pinacol coupling reactions

Titanium compounds use in pinacol coupling reactions

Transition Metal-Catalyzed Couplings of Nonactivated Aryl Compounds

ZACA-Pd-Catalyzed Cross-Coupling Sequential Processes for the Synthesis of Deoxypolypropionates and Related Compounds

Zinc Compounds couple

Zinc compounds coupling reactions

Zinc-copper couple benzylic compounds

Zinc-copper couple carbonyl compounds

Zinc-copper couple compounds

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