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Chemokines rheumatoid arthritis

Chemokines have been shown to be associated with a number of autoinflammatory diseases including multiple sclerosis, rheumatoid arthritis, atherosclerosis, dermatitis, and organ transplant rejection. Evidence, reviewed below, is mounting that chemokines may play a major role in the pathophysiology of these diseases and thus chemokine receptor antagonists could prove to be useful therapeutics in treating these and other proinflammatory diseases. [Pg.352]

Galligan C, Matsuyama W, Matsukawa A, et al. Up-regulated expression and activation of the orphan chemokine receptor, CCRL2, in rheumatoid arthritis. Arthritis Rheum 2004 50 1806-1814. [Pg.85]

Key Words Chemokines chemokine receptors rheumatoid arthritis murine models. [Pg.155]

Role of Chemokines During the Different Phases of Rheumatoid Arthritis... [Pg.156]

Chemokines and Chemokine Receptors Implicated in Rheumatoid Arthritis Human Studies... [Pg.161]

Key Chemokines and Chemokine Receptors Relevant in Rheumatoid Arthritis Compared with Other Arthritides ... [Pg.166]

Finally, Santiago et al. (47) demonstrated that lymphocyte chemoattraction induced by rheumatoid arthritis synovial fluid is independent of CCR5. They showed that T cells from individuals with CCR5 delta 32 mutation (a 32-base-pair frameshift deletion resulting in absent CCR5 expression) migrate normally to chemokines present in the synovial fluids of RA patients (47). [Pg.170]

Effects of Chemokines in Rheumatoid Arthritis Beyond Cell Recruitment... [Pg.182]

Haringman JJ, Smeets TJ, Reinders-Blankert P, Tak PP. Chemokine and chemo-kine receptor expression in paired peripheral blood mononuclear cells and synovial tissue of patients with rheumatoid arthritis, osteoarthritis, and reactive arthritis. Ann Rheum Dis 2006 65(3) 294-300. [Pg.186]

Quinones MP, Ahuja SK, Jimenez F, et al. Experimental arthritis in CC chemokine receptor 2-null mice closely mimics severe human rheumatoid arthritis. J Clin Invest 2004 113(6) 856-866. [Pg.186]

Quinones MP, Estrada CA, Kalkonde Y, et al. The complex role of the chemokine receptor CCR2 in collagen-induced arthritis implications for therapeutic targeting of CCR2 in rheumatoid arthritis. J Mol Med 2005 83(9) 672-681. [Pg.187]

Santiago B, Galindo M, Rivero M, Brehmer MT, Mateo I, Pablos JL. The che-moattraction of lymphocytes by rheumatoid arthritis—synovial fluid is not dependent on the chemokine receptor CCR5. Rheumatol Int 2002 22(3) 107-111. [Pg.187]

Gomez-Reino JJ, Pablos JL, Carreira PE, et al. Association of rheumatoid arthritis with a functional chemokine receptor, CCR5. Arthritis Rheum 1999 42(5) 989-992. [Pg.188]

Zapico I, Coto E, Rodriguez A, Alvarez C, Torre JC, Alvarez V. CCR5 (chemokine receptor-5) DNA-polymorphism influences the severity of rheumatoid arthritis. Genes Immun 2000 l(4) 288-289. [Pg.188]

Pokomy V, McQueen F, Yeoman S, et al. Evidence for negative association of the chemokine receptor CCR5 d32 polymorphism with rheumatoid arthritis. Ann Rheum Dis 2005 64(3) 487 190. [Pg.188]

Katschke KJ Jr, Rottman JB, Ruth JH, et al. Differential expression of chemokine receptors on peripheral blood, synovial fluid, and synovial tissue monocytes/mac-rophages in rheumatoid arthritis. Arthritis Rheum 2001 44(5) 1022-1032. [Pg.189]

Robinson E, Keystone EC, Schall TJ, Gillett N, Fish EN. Chemokine expression in rheumatoid arthritis (RA) evidence of RANTES and macrophage inflammatory protein (MIP)-l beta production by synovial T cells. Clin Exp Immunol 1995 101(3) 398-107. [Pg.189]

Borzi RM, Mazzetti I, Macor S, et al. Flow cytometric analysis of intracellular chemokines in chondrocytes in vivo constitutive expression and enhancement in osteoarthritis and rheumatoid arthritis. FEBS Lett 1999 455(3) 238-242. [Pg.190]

Haringman JJ, Kraan MC, Smeets TJ, Zwinderman KH, Tak PP. Chemokine blockade and chronic inflammatory disease proof of concept in patients with rheumatoid arthritis. Ann Rheum Dis 2003 62(8) 715-721. [Pg.191]

Burman A, Haworth O, Hardie DL, et al. A chemokine-dependent stromal induction mechanism for aberrant lymphocyte accumulation and compromised lymphatic return in rheumatoid arthritis. J Immunol 2005 174(3) 1693-1700. [Pg.192]

Pierer M, Rethage J, Seibl R, et al. Chemokine secretion of rheumatoid arthritis synovial fibroblasts stimulated by Toll-like receptor 2 ligands. J Immunol 2004 172(2) 1256-1265. [Pg.192]

Klimiuk PA, Sierakowski S, Latosiewicz R, et al. Histological patterns of synovitis and serum chemokines in patients with rheumatoid arthritis. J Rheumatol... [Pg.192]

Katrib A, Tak PP, Bertouch JV, et al. Expression of chemokines and matrix metalloproteinases in early rheumatoid arthritis. Rheumatology (Oxford) 2001 40(9) 988-994. [Pg.192]

Thompson SD, Luyrink LK, Graham TB, et al. Chemokine receptor CCR4 on CD4+ T cells in juvenile rheumatoid arthritis synovial fluid defines a subset of cells with increased IL-4 IFN-gamma mRNA ratios. J Immunol 2001 166(11) 6899-6906. [Pg.193]

Page G, Miossec P. Paired synovium and lymph nodes from rheumatoid arthritis patients differ in dendritic cell and chemokine expression. J Pathol 2004 204(1) 28-38. [Pg.193]

Ueno A, Yamamura M, Iwahashi M, et al. The production of CXCR3-agonistic chemokines by synovial fibroblasts from patients with rheumatoid arthritis. Rheumatol Int 2005 25(5) 361-367. [Pg.194]

Grassi F, Cristino S, Toneguzzi S, Piacentini A, Facchini A, Lisignoli G. CXCL12 chemokine up-regulates bone resorption and MMP-9 release by human osteoclasts CXCL12 levels are increased in synovial and bone tissue of rheumatoid arthritis patients. J Cell Physiol 2004 199(2) 244-251. [Pg.195]

Nanki T, Hayashida K, El-Gabalawy HS, et al. Stromal cell-derived factor-l-CXC chemokine receptor 4 interactions play a central role in CD4+ T cell accumulation in rheumatoid arthritis synovium. J Immunol 2000 165(11) 6590-6598. [Pg.195]

Blaschke S, Middel P, Domer BG, et al. Expression of activation-induced, T cell-derived, and chemokine-related cytokine/lymphotactin and its functional role in rheumatoid arthritis. Arthritis Rheum 2003 48(7) 1858-1872. [Pg.195]

Ruth JH, Volin MV, Haines GK 3rd, et al. Fractalkine, a novel chemokine in rheumatoid arthritis and in rat adjuvant-induced arthritis. Arthritis Rheum 2001 44(7) 1568—1581. [Pg.195]

Nanki T, Nagasaka K, Hayashida K, Saita Y, Miyasaka N. Chemokines regulate IL-6 and IL-8 production by fibroblast-like synoviocytes from patients with rheumatoid arthritis. J Immunol 2001 167(9) 5381—5385. [Pg.196]

See other pages where Chemokines rheumatoid arthritis is mentioned: [Pg.185]    [Pg.353]    [Pg.353]    [Pg.888]    [Pg.48]    [Pg.138]    [Pg.332]    [Pg.208]    [Pg.77]    [Pg.155]    [Pg.160]    [Pg.184]    [Pg.188]    [Pg.373]    [Pg.382]    [Pg.384]   
See also in sourсe #XX -- [ Pg.378 ]

See also in sourсe #XX -- [ Pg.378 ]



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