Rheumatoid arthritis synovial fibroblasts

Pierer M, Rethage J, Seibl R, et al. Chemokine secretion of rheumatoid arthritis synovial fibroblasts stimulated by Toll-like receptor 2 ligands. J Immunol 2004 172(2) 1256-1265. 

Karouzakis E, Gay RE, Michel BA, Gay S, Neidhart. M. DNA hypomethylation in rheumatoid arthritis synovial fibroblasts. Arthritis... 

Stanczyk J, Ospelt C, Karouzakis E, et al. Altered expression of microRNA-203 in rheumatoid arthritis synovial fibroblasts and its role... 

Rheumatoid arthritis synovial fibroblasts (RASFs) are known to produce matrix metalloproteinases (MMPs) and cause joint destruction. 10-HDA tested how to inhibit the activities of MMPs with RASFs isolated from rheumatoid tissues by enzymatic digestion, cultures in monolayers were treated with 10-HDA (0.5, 1, and 2mM). The molecular investigation revealed that... 

Min DJ, Cho ML, Lee SH, et al. Augmented production of chemokines by the interaction of type II collagen-reactive T cells with rheumatoid synovial fibroblasts. Arthritis Rheum 2004 50(4) 1146-1155. 

Hanyuda M, Kasama T, Isozaki T, et al. Activated leucocytes express and secrete macrophage inflammatory protein-lalpha upon interaction with synovial fibroblasts of rheumatoid arthritis via a beta2-integrin/ICAM-l mechanism. Rheumatology (Oxford) 2003 42(11) 1390-1397. 

Ueno A, Yamamura M, Iwahashi M, et al. The production of CXCR3-agonistic chemokines by synovial fibroblasts from patients with rheumatoid arthritis. Rheumatol Int 2005 25(5) 361-367. 

Penicillamine (Cuprimine) can be used to treat acute, severe rheumatoid arthritis, producing reductions in joint pain, edema, and stiffness. The response to penicillamine is usually delayed (4-12 weeks), and remissions can last several months after withdrawal of treatment. Radiographic evidence of this drug s efficacy is limited thus, penicillamine is seldom used to treat rheumatoid arthritis. The mechanism of action of penicillamine is unknown, but some evidence suggests that it may involve the inhibition of angiogenesis, synovial fibroblast proliferation, or transcriptional activation. Because penicillamine can chelate copper and promote its excretion, it is used to treat Wilson s disease (hepatolenticular degeneration) and has also been used in mercury and lead intoxication. 

The synovial proteome analysis of fibroblast-like synoviocytes. Arthritis Res. Ther. 6, R161-R168, 2004 Romeo, M.J., Espina, V., Lowenthal, M. et al., CSE proteome a protein repository for potential biomarker idenfi-cation. Expert. Rev. Proteomics 2, 57-70, 2005 Hueber, W., Kidd, B.A., Tomooka, B.H. et al.. Antigen microarray profiling of autoantibodies in rheumatoid arthritis. Arthritis Rheum. 52, 2645-2655, 2005. 

Taylor, D. J. (1994). Cytokine combinations increase p75 tumor necrosis factor receptor binding and stimulate receptor shedding in rheumatoid synovial fibroblasts. Arthritis Rheum. 37, 232-235. 

Bradfield PF, Amft N, Vemon-Wilson E, et al. Rheumatoid fibroblast-like synoviocytes overexpress the chemokine stromal cell-derived factor 1 (CXCL12), which supports distinct patterns and rates of CD4+ and CD8+ T cell migration within synovial tissue. Arthritis Rheum 2003 48(9) 2472-2482. 

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