Dendritic cells immune cell migration

Regulation by Chemokines of Dendritic Cell Migration-Dependent Immunity... 

Regulation of dendritic cell migration and adaptive immune response by leukotriene B4 receptors a role for LTB4 in up-regulation of CCR7 expression and function. Blood 2007 109 ... 

Cutaneous reactions such as rash or Stevens-Johnson syndrome are also consist with initiation through protein haptenation, although in this case dendritic cell activation/ migration and T-cell propagation are involved [31]. Other immune mediators such as cytokines, nitric oxide and reactive oxygen species which may be linked to the formation of reactive metabolites may also be implicated, as may specific processes occurring at the level of the keratinocyte. 

Chemokines are a superfamily of small proteins which play a crucial role in immune and inflammatory reactions and in viral infection (Hedrick and Zlotnik, 1996 Baggi-olini et al, 1997 Rollins, 1997). Most chemokines cause migration of leukocytes, but these molecules also affect angiogenesis, proliferation of hematopoietic precursors, and viral responses. Based on a cysteine motif, a CXC, CC, C and CX3C family have been identified (Fig. 1). CXC (or a) chemokines are active on neutrophils and lymphocytes while CC (or (3) chemokines exert their action on multiple leukocyte subtypes, including monocytes, basophils, eosinophils, T-lymphocytes, dendritic cells (DC) and NK cells, but they are generally inactive on PMN. Eotaxins... 

Fig. 1 Tumour immunosurveillance and the role of the main immnne cell types. The immune response against cancer may be initiated by cells of the innate immune system, by external damage to the tumour cells and via other mechanisms. Tumour antigens, taken up by dendritic cells (DC), are carried into secondary lymphoid organs where T cell priming occurs. CD4 + T cells provide help for B cell and CDS + T cell responses. CDS + tumour-antigen-specific T cells become activated and migrate to the periphery where they recognise and destroy malignant cells...

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