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Receptors Role in Tumor Cell Migration

Chemokine Receptors Role in Tumor Cell Migration [Pg.7]

The chemokine receptors are a subset of the G-protein-coupled receptor superfamily. They are seven-transmembrane receptors that bind G proteins at activation. For the chemokines, the receptors are highly related, and most exhibit a characteristic DRY box. For this reason, many so-called orphan receptors that showed significant homology with known chemokine receptors that contain a DRY box, were widely believed to be chemokine receptors. As shown in Table [Pg.7]

Marcel Dekker, Inc. 270 Madison Avenue, New York, New York 10016 [Pg.7]

this turned out to be true, as the former orphan GPR2, GPR5, and GPR9 receptors were eventually found to be the receptors of CCL27/28, XCLl, and CCL25, respectively. [Pg.8]


V. Chemokine Receptors Role in Tumor Cell Migration... [Pg.7]




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