Cell-surface interactions migration

Lectins also play a significant role in the development of cancer, being implicated in processes including cell replication, migration and formation of metastases. Thus inhibiting these cell surface interactions offers an alternative approach to classical chemotherapy in the treatment of cancer. 

Integrins constitute a large family of a (3 heterodimeric cell surface, transmembrane proteins that interact with a large number of extracellular matrix components through a metal ion-dependent interaction. The term integrin reflects their function in integrating cell adhesion and migration with the cystoskeleton. 

Cell adhesion molecules (CAMs) play critical roles in all facets of nervous system development and maintenance. Important phenomena in which CAMs are involved include initial formation of the neural tube and the neural crest, migration of all neurons and glial cells, axonal outgrowth and guidance, target selection, synaptic stabilization and plasticity, myelination and nerve regeneration after injury (see Chs 4,24,28-30 and 53). Adhesion molecules interact with each other and with nonadhesive cell-surface and/or cytoplasmic molecules, and, in the two... 

The integrins comprise a family of cell-surface proteins that are involved in adhesion, a process vital for many processes, such as anchorage, migration, growth and differentiation. Cells may adhere to other cells (cell-cell adhesion) or may interact with soluble molecules that constitute the extracellular matrix (cell-extracellular matrix). The integrins are linked to elements of the cytoskeleton, and so they provide a bridge between the external cellular environment and intracellular activation processes. 

Synthetic two-dimensional (2D) materials with nanometer textured surfaces have been fabricated by sophisticated technologies, like dip-pen printing [36] or e-beam lithography [37], to elucidate the interactions of cells with defined surfaces. Cell-nanostructure interactions were studied from the gene expression level (cell metabolism) up to the level of microscopic cell behavior. Understanding of the influences of nanostructure on cell adhesion, orientation, motility, proliferation, migration, or differentiation is accessible [38], In terms of adhesion, proliferation... 

Adhesive interactions play critical roles in the migration of cells. These interactions are mediated by cell-surface receptors, the integrins that bind to components of the extra-celluar matrix and/or to ligands presented by adjacent cells. Consequently, these interactions lead to the formation of intracellular cytoskeletal assemblies and actin bundles (Fig. 4.4). 

Galactosyltransferase is only one member within the broader classification of glycosyltransferases that have been found on cell surfaces these are involved in contact-mediated cell interactions in general, but more specifically are involved in fertilization, morphogenesis, hemostasis, and cell migration. This topic has been well reviewed by Pierce et al. (1980). 

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