T-cells migration

Receptor Expression Ligand PI3K activation Effect of inhibitors on T-cell migration... 

Ottoson NC, Pribila JT, Chan AS, Shimizu Y. Cutting edge T cell migration regulated by CXCR4 chemokine receptor signaling to ZAP-70 tyrosine kinase. J Immunol 2001 167(4) 1857-1861. 

Mackay CR, Marston W, Dudler L. Altered patterns of T cell migration through lymph nodes and skin following antigen challenge. Eur J Immunol 1992 22 2205-2210. 

Bradfield PF, Amft N, Vemon-Wilson E, et al. Rheumatoid fibroblast-like synoviocytes overexpress the chemokine stromal cell-derived factor 1 (CXCL12), which supports distinct patterns and rates of CD4+ and CD8+ T cell migration within synovial tissue. Arthritis Rheum 2003 48(9) 2472-2482. 

Engelhardt B (2006) Molecular mechanisms involved in T cell migration across the blood-brain banier. J Neural Transm 113 477 85. 

IL-3 stimulates the growth and differentiation of all hematopoietic lineages rather than self-renewal of primitive stem cells. Activated T cells secrete IL-3, but its effects are normally restricted to local cellular activation or to nearby sites where T cells migrate (paracrine action). Other general characteristics of IL-3 include ... 

Mclnnes IB, al-Mughales J, Field M, et al. The role of interleukin-15 in T-cell migration and activation in rheumatoid arthritis. Nat Med 1996 2 175-82. 

Efalizumab is a humanized monoclonal antibody (IgGi) against CDll-a integrin. CDll-a/CD18 comprise subunits of LFA-1, a T-cell surface molecule important in T-cell activation, T-cell migration into skin, and cytotoxic T-cell function. ... 

Xia, M., Leppert, D., Hauser, S. L., Sreedharan, S. P., Nelson, P. J., Krensyk, A. M., and Goetzl, E. J. (1996a). Stimulus-specificity of matrix metalloproteinase-dependence of human T cell migration through a model basement membrane. J. Immunol. 156, 176-167. 

Kano H, Ito Y, Matsuoka K, Nakajima T, Iwata T, Kohsaka T, Saito H, Abe J Critical role of T cell migration in bacterial superantigen-mediated shock in mice. Clin Immunol 2004 110 159-171. 

Lymphocytes all develop from pluripotential stem cells located in the red bone marrow. Most B cells complete their development in the bone marrow, whereas precursor T cells migrate from the bone marrow to the thymus, where they mature. When mature B cells encounter their corresponding antigen, they proliferate and... 

T. Hamaoka. 2002. A pivotal role for CC chemokine receptor 5 in T-cell migration to tumor sites induced by interleukin 12 treatment in tumor-bearing mice. Cancer Res 62 3751. 

Zheng, Y., Kong, Y., Goetzl, E. J. Lysophosphatidic acid receptor-selective effects on Jurkat T cell migration through a Matrigel model basement membrane. J Immunol 166 (2001) 2317-2322. 

---