Tumor cell migration

S. K., Monoclonal antibodies and synthetic peptides as inhibitors of human tumor cell migration. Cancer Res. 50, 4485-4496 (1990). 

The Rationale for Studying Tumor Cell Migration and Invasion... 

Tumor cell migration out of spheroids onto ECM or along aligned nanofibers... 

Echeverria V, Meyvantsson I, Skoien A et al (2010) An automated high-content assay for tumor cell migration through 3-dimensional matrices. J Biomol Screen 15 1144-1151... 

Wolf K, Mazo I, Leung H et al (2003) Compensation mechanism in tumor cell migration mesenchymal-amoeboid transition after blocking of pericellular proteolysis. J Cell Biol 160 267-277... 

Drug Treatment for Inhibition of Tumor Cell Migration 1. Drug or inhibitor to be tested. Here we use cisplatin cis-diammineplatinum(ll) dichloride), stored in aliquots of 100 mM in dimethyl sulfoxide (DMSO) at -20°C for up to 4 weeks. 2. DMSO or appropriate solvent for the agent under test. 

Evaluation of Test Agents for Inhibition of Tumor Cell Migration... 

Bourguignon, L. Y. W., Gunja-Smith, Z., Bda, N., Zhu, H. B., Young, L. J. T, Muller, W. J. and Cardiff, R. D. (1998). CD44v3,8-10 is involved in cytoskeleton-mediated tumor cell migration and matrix metalloproteinase (MMP-9). association in metastatic breast cancer cells. J. Cell Physiol. 59176, 206-215. 

Taraboletti, G., Roberts, D. D. and Liotta, L. A. (1987). Thrombospondin-induced tumor cell migration haptotaxis and chemotaxis are mediated by different molecular domains. J. Cell Biol. 105, 2409-2415. 

Yamada, K. M., Kennedy, D. W., Yamada, S. S., Gralnick, H., Chen, W. T. and Akiyama, S. K. (1990). Monoclonal antibody and synthetic peptide inhibitors of human tumor cell migration. Cancer Res. 50, 4485-4496. 

Zhang QH, Wang SY, Nottke AC, Rocheleau JV. Piston DW. Goodman RH (2006) Redox sensor CtBP mediates hypoxia-induced tumor cell migration. Proc Natl Acad Sci USA 103 9029-9033... 

Wyckoff, J., W. Wang, E. Y. Lin, Y. Wang, F. Pixley, E. R. Stanley, T. Graf, J. W. Pollard, J. Segall, and J. Condeehs. 2004. A paracrine loop between tumor cells and macrophages is required for tumor cell migration in mammary tumors. Cancer Res 64 7022. 

Besides the role of chemokines and their receptors in angiogenesis, they also seem to be involved in the process of tumor cell migration, invasion, and metastasis. It is known that certain tumors exhibit specific patterns of... 

HA is able to interact in an autocrine manner with its cell surface receptors that are located on the same cell, i.e. the cell is influenced by a product produced by this cell itself. For instance, it has been recently shown [113] that low-molar-mass HA induces the proteolytic cleavage of CD44 from the surface of tumor cells and promotes tumor cell migration significantly in this manner. 

Bjorklund M, Heikkila P, Koivunen E (2004) Peptide inhibition of catalytic and non-catalytic activities of matrix metalloproteinase-9 blocks tumor cell migration and invasion. J Biol Chem 279 29589-29597... 

Sahlgren C, Gustafsson MV, Jin S, PoeUinger L, I endahl U. Notch signaUng mediates hypoxia-induced tumor cell migration and invasion. Proc Natl Acad Sci USA 2008 105(17) 6392 397. 

---