Dendritic cells migration

Key Words Chemokine dendritic cell migration inflammation lymph node. 

Regulation by Chemokines of Dendritic Cell Migration-Dependent Immunity... 

Randolph GJ. Dendritic cell migration to lymph nodes cytokines, chemokines, and lipid mediators. Semin Immunol 2001 13(5) 267-274. 

Gunn, M.D., Chemokine mediated control of dendritic cell migration and function, Semin. Immunol. 15, 5, 271, 2003. 

Suto H, Nakae S, Kakurai M, Sedgwick JD, Tsai M, Galli SJ Mast cell-associated TNF promotes dendritic cell migration. 

Fainaru 0, Shseyov D, Hantisteanu S, Groner Y Accelerated chemokine receptor 7-mediated dendritic cell migration in Runx3 knockout mice and the spontaneous development of asthma-like disease. Proc Natl Acad Sci USA 2005 102 10598-10603. 

Hammad H, de Heer HJ, Souillie T, Hoogsteden HC, Trottein F, Lambrecht BN Prostaglandin Dj modifies airway dendritic cell migration and function in steady-state conditions by selective activation of the DP receptor. J Immunol 2003 171 3936-3940. 

Regulation of dendritic cell migration and adaptive immune response by leukotriene B4 receptors a role for LTB4 in up-regulation of CCR7 expression and function. Blood 2007 109 ... 

The relevance of the A3 receptor over the other adenosine subtypes in immature human dendritic cells is attested to by different studies demonstrating a role for this receptor in the increase of intracellular calcium, actin polymerization and chemot-axis (Panther et al. 2001 Fossetta et al. 2003) (Fig. 12.5). However a loss of the A3 and an increase of the A2A receptor has been reported during maturation of dendritic cells. This switch has been interpreted as a protective effect of adenosine in the context of tissue injury as A2A activation plays an inhibitory role on dendritic cells migration. In this way adenosine could counterbalance inflammatory stimuli by delaying the arrival of mature dendritic cells to lymph nodes, thereby impairing the... 

Dendritic cells are very important APCs along with mononuclear phagocytes. They are distributed in small quantities in various tissues that come in contact with the external environment including the skin, inner lining of the nose, lungs, stomach and intestine. The blood contains immature dendritic cells. After activation, dendritic cells migrate to the lymphoid tissue to initiate an acquired response following their interaction with lymphoid cells, B and T cells. There are two most common types... 

Hatterer E, Davoust N, Didier-Bazes M, Vuaillat C, Malcus C, Belin MF, Nataf S (2006) How to drain without lymphatics Dendritic cells migrate from the cerebrospinal fluid to the B-cell follicles of cervical lymph nodes. Blood 107 806-812. 

Sozzani S, Mantovani A, Allavena P Control of dendritic cell migration by chemokines. Fomm (Genova) 1999 9 325-338. 

Back JH, Birchmeier C, Zenka M, Hieronymus T. The HGF receptor/Met tyrosine kinase is a key regulator of dendritic cell migration in skin immunity. J ImmunoL 2012 189 1699-709. 

Ohl, L., Mohaupt, M., Czeloth, N., Hintzen, G., Kiafard, Z., Zwimer, J., et al. (2004). CCR7 governs skin dendritic cell migration under inflammatory and steady-state conditions. Immunity, 21(2), 279—288. 

CCR6 LARC T-cell and dendritic cell migration, antigen presentation. 

Kobayashi, H., Miura, S., Nagata, H., Tsuzuki, Y., Hokari, R., Ogino, T., Watanabe, C., Azuma, T., and Ishii, H. (2004). In situ demonstration of dendritic cell migration from rat intestine to mesenteric lymph nodes Relationships to maturation and role of chemokines. J. Leukoc. Biol. 75, 434—442. 

Darmanin S, Chen J, Zhao S et al. 2007. AU-trans retinoic acid enhances murine dendritic cell migration to draining lymph nodes via the balance of matrix metalloproteinases and their inhibitors. J. Immunol. 179 4616-4625. 

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