Neurocrine cell migration

The direct link between the nose and the reproductive system has been called a non-cognitive bridge (Stoddart, 1990). A part of VN projection is non-olfactory and reaches the limbic system via a direct and monosynaptic relay (Larriva-Sahd et al., 1993 and 1994 Matsumoto et al., 1994). In addition to the production of the peripheral olfactory cells (Sec. 4.1 above), the placode also gives rise to a group of important 

The ontogenesis of the AOS then, is closely bound up with the formation of its principal connection site within the mature brain. The sequence of events in mammals is revealed as a process which involves (1) early specialisation of presumptive GnRH cells (2) their attachment to and movement along specific (and transient) axonal bundles of the VN and N. terminalis tracts, and (3) coalescence of the neurocrine cells in the hypothalamus, where they complete differentiation as multi-axonal neurocrine cells. 

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Fig. 4.6(a) Migration of LHRH neurocrine cells prenatal transportation along the track of extra-bulbar VN axons (caudal branch). CB, cribriform plate FB, forebrain cell types, TAG-1, transient axonal surface glycoprotein and N-CAM, neural cell adhesion molecule (from Yoshida et al, 1995). 

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