Cell invasion

Marimastat Metalloproteinase inhibitor, inhibits endothelial cell invasion... 

MA M10 M10.014 Membrane-type matrix m etallo pe pt id ase-1 Potential drug target for tumor cell invasion... 

Lutolf MP, Lauer-Fields JL, Schmoekel HG et al (2003) Synthetic matrix metalloproteinase-sensitive hydrogels for the conduction of tissue regeneration Engineering cell-invasion characteristics. Proc Natl Acad Sci 100 5413-5418... 

Ehtesham M, Winston JA, Kabos P, Thompson RC (2006) CXCR4 expression mediates glioma cell invasiveness. Oncogene 25 2801-2806... 

Zagzag D, Lukyanov Y, Lan L, Ah MA, Esencay M, Mendez O, Yee H, Voura EB, Newcomb EW (2006) Hypoxia-inducible factor 1 and VEGF upregulate CXCR4 in glioblastoma implications for angiogenesis and glioma cell invasion. Lab Invest 86 1221-1232... 

This interceptor theory does not seem to be the only protective mechanism in operation. Inhibition of cytochrome P450 enzymes related to the bioactivation of mutagens and toxic radical scavenger activities have been proposed to integrate the different modes of action. Other investigations have reported the involvement of chlorophyUin in inducing apoptosis in human colon cells, which may be important in limiting cancer cell invasion and metastasis. ... 

Chen Y, Stamatoyannopoulos G, Song C-Z. Down-regulation of CXCR4 by inducible small interfering RNA inhibits breast cancer cell invasion in vitro. Cancer Res 2003 63 4801 1804. 

Kimsey TF, Campbell AS, Albo D, Wang TN. Co-localization of macrophage inflammatory protein-3a (Mip-3a) and its receptor, CCR6, promotes pancreatic cancer cell invasion. Cancer J 2004 10 374-380. 

EIEC all ages/primarily in the developing regions occasional outbreaks in industrialized countries as short as 10-18 h acute watery diarrhea followed by dysentery cell invasion spread inflammation... 

Inhibition of Metastasis by Protease Inhibitors. Cancer metastasis can be inhibited by either synthetic or naturally occurring protease inhibitors. Thus, various synthetic inhibitors of serine proteases have been found to prevent tumor cell invasion through amniotic membranes in vitro and to inhibit cancer metastasis in vivo [for reviews, see Aznavoorian et al. (A4) and Duffy (D6). In... 

A4. Aznavoorian, S., Murphy, A. N., Stetler-Stevenson, W. G., and Liotta, L. A., Molecular aspects of tumor cell invasion and metastasis. Cancer (Philadelphia) 71, 1368-1383 (1993). 

Azuma, L, and Mochizuki, M. (1994). Inhibition of tumor cell invasion and metastasis by ginsenosides. Ginseng Rev. 18,37-39. 

Bernet, M. F., Brassart, D., Neeser, J. R., and Servin, A. L. (1994). Lactobacillus acidophilus Lai binds to cultured human intestinal cell lines and inhibits cell attachment and cell invasion by enterovirulent bacteria. Gut 35, 483-489. 

Hernandes, R. T., Silva, R. M., Carneiro, S. M., Salvador, F. A., Fernandes, M. C., Padovan, A. C., Yamamoto, D., Mortara, R. A., Elias, W. P., da Silva Briones, M. R., and Gomes, T. A. (2008). The localized adherence pattern of an atypical enteropathogenic Escherichia coli is mediated by intimin omicron and unexpectedly promotes HeLa cell invasion. Cell. Microbiol. 10, 415 25. 

Young, G. M., Badget, J. L., and Miller, V. L. (2000). Motility is required to initiate host cell invasion by Yersinia enterocolitica. Infect. Immun. 68, 4323-4326. 

About 10-20% of all transmembrane proteins that are targeted to the ER and subsequently enter the secretory pathway are subject to post-translational modification with glycosylphosphatidyl-inositol (GPI). Proteins bearing the GPI anchor are involved in signal transduction, immune response, cancer cell invasion, and metastasis and the pathobiology of trypanosomal parasites. The structure of the GPI anchor has been analyzed for mammals, protozoa, and yeast. The general structure of the glycolipid structure is shown in Scheme 4. 

Ulrich H, Magdesian MH, Alves MJ et al (2002) In vitro selection of RNA aptamers that bind to cell adhesion receptors of Trypanosoma cruzi and inhibit cell invasion. J Biol Chem 277 20756-20762... 

Variations on the filter-based assay have been designed to approximate more physiological contexts. Such assays include tumor cell invasion across a confluent cell monolayer (e.g., endothelial cells (EC) as a surrogate for intravasation or extravasation during hematogenous metastasis (24)) and ovarian carcinoma invasion of mesothelial cell monolayers (25). Additionally, 1 mm thick slices of human brain tissue have been used as a tissue barrier on Transwell filters with invasion of GFP-labeled glioma cells measured by confocal microscopy (26). 

Brain microvascular EC monolayers together with an astrocyte-enriched subendothelial collagen gel can be used to simulate the blood-brain barrier (BBB) (39). Such systems are invaluable to screen for compounds able to penetrate the BBB to access brain tumors or metastases. In addition, glioma cell invasion into brain fragments has enabled better understanding of the properties of these highly invasive tumors and identification of potential therapeutic targets (40). 

Sahai E, Marshall CJ (2003) Differing modes of tumour cell invasion have distinct requirements for Rho/ROCK signalling and extracellular proteolysis. Nat Cell Biol 5 711-719... 

Albini A, Noonan DM (2010) The chemoin-vasion assay, 25 years and still going strong the use of reconstituted basement membranes to study cell invasion and angiogenesis. Cirrr Opin CeU Biol 22 677-689... 

Quintavalle M, Elia L, Price JH et al (2011) A cell-based high-content screening assay reveals activators and inhibitors of cancer cell invasion. Sci Signal 4 ra49... 

Nystrom ML, Thomas GJ, Stone M et al (2005) Development of a quantitative method to analyse tumour cell invasion in organotypic culture. J Pathol 205 468-475... 

Brekhman V, Neufeld G (2009) A novel asymmetric 3D in-vitro assay for the study of tumor cell invasion. BMC Cancer 9 415... 

Duong HS, Le AD, Zhang Q et al (2005) A novel 3-dimensional culture system as an in vitro model for studying oral cancer cell invasion. Int J Exp Pathol 86 365-374... 

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