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High content screening assays

Quintavalle M, Elia L, Price JH et al (2011) A cell-based high-content screening assay reveals activators and inhibitors of cancer cell invasion. Sci Signal 4 ra49... [Pg.248]

Wilson, C.J. et al. 2006. Identification of a small molecule that induces mitotic arrest using a simplified high-content screening assay and data analysis method. J. Biomol. Screen. 11, 21-28. [Pg.155]

Bowen WP, Wylie PG. Application of laser-scanning fluores- 96. cence microplate cytometry in high content screening. Assay... [Pg.704]

Nadanaciva S, Lu S, Gebhard DF, lessen BA, Peimie WD, Will Y (201 lb) A high content screening assay for identifying lysosomotropic compounds. Toxicol In Vitro 25, 715-23. [Pg.126]

Persson M, Lpye AF, Mow T, Homberg JJ (2013) A high content screening assay to predict human drug-induced liver injury during drug discovery. J Pharmacol Toxicol Methods 68,... [Pg.126]

Smaller compound sets and focused compound libraries can be used to screen more broadly for physiological phenotypes. In the typical high-content screening experiment, the effects of compounds on cellular assays are captured... [Pg.6]

Giuliano, K.A., Haskins, J.R., and Taylor, D.L. 2003. Advances in high content screening for drug discovery. Assay Drug Dev. Technol. 1, 565-577. [Pg.154]

High-throughput automated imaging systems, also sometimes referred to as high content screening (HCS) systems, enable the study of specific cell types within a mixed population of cells (Giuliano, 1997). Some primary cell types are dependent on interactions with other cell types, making their cultivation in isolation impossible, at least at the present time. Even when primary cells are not dependent on interactions with other cell types, primary cell preparations are almost never 100% pure, which could potentially lead to problems in assay quality and reproducibility. Systems such... [Pg.176]

The use of dual microelectrodes and the implementation of an automated distance control in the electrochemical robotic system drastically improved the readout of the NO assays and made electrochemical high-content screening of released NO from endothelial cells possible. [Pg.363]

Westerink WM, Schirris TJ, Horbach GJ, Schoonen WG (2011) Development and validation of a high-content screening in vitro micronucleus assay in CHO-kl and HepG2 cells. Mutat Res 724 7-21... [Pg.328]

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See also in sourсe #XX -- [ Pg.76 ]



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High assay

High content

High content screening

High screen

High screening

High-content screen

Screening assay

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