Tumor cell invasion

MA M10 M10.014 Membrane-type matrix m etallo pe pt id ase-1 Potential drug target for tumor cell invasion... 

Inhibition of Metastasis by Protease Inhibitors. Cancer metastasis can be inhibited by either synthetic or naturally occurring protease inhibitors. Thus, various synthetic inhibitors of serine proteases have been found to prevent tumor cell invasion through amniotic membranes in vitro and to inhibit cancer metastasis in vivo [for reviews, see Aznavoorian et al. (A4) and Duffy (D6). In... 

A4. Aznavoorian, S., Murphy, A. N., Stetler-Stevenson, W. G., and Liotta, L. A., Molecular aspects of tumor cell invasion and metastasis. Cancer (Philadelphia) 71, 1368-1383 (1993). 

Azuma, L, and Mochizuki, M. (1994). Inhibition of tumor cell invasion and metastasis by ginsenosides. Ginseng Rev. 18,37-39. 

Variations on the filter-based assay have been designed to approximate more physiological contexts. Such assays include tumor cell invasion across a confluent cell monolayer (e.g., endothelial cells (EC) as a surrogate for intravasation or extravasation during hematogenous metastasis (24)) and ovarian carcinoma invasion of mesothelial cell monolayers (25). Additionally, 1 mm thick slices of human brain tissue have been used as a tissue barrier on Transwell filters with invasion of GFP-labeled glioma cells measured by confocal microscopy (26). 

Brekhman V, Neufeld G (2009) A novel asymmetric 3D in-vitro assay for the study of tumor cell invasion. BMC Cancer 9 415... 

Hart IR, Fidler IF (1978) An in vitro quantitative assay for tumor cell invasion. Cancer Res 38 3218-3224... 

Hyalurondiases, which depolymerize hyaluronic acid to oligosaccharides by breaking glu-cosaminidic bonds, have been referred to as a spreading factor, and are possibly involved in tumor cell invasiveness. The most effective flavonoids are kaempferol and silybin. 

Ramos-DeSimone N, Hahn-Dantona E, Sipley J et al (1999) Activation of matrix metalloproteinase-9 (MMP-9) via a converging plasmin/stromelysin-1 cascade enhances tumor cell invasion. J Biol Chem 274 13066-13076... 

Bourguignon, L.Y.etal., CD44 interaction with Na+-H+exchanger (NHE1) creates acidic microenvironments leading to hyaluronidase-2 and cathepsin B activation and breast tumor cell invasion, J. Biol. 

Gong, Y. and Frenkel, G.D. 1994. Effect of selenite on tumor cell invasiveness. Cancer Lett. 78, 195-199. 

Kobayashi H, Sugino D, She MY, Ohi H, Hirashima Y, Shinohara H, et al. A bifunctional hybrid molecule of the amino-terminal fragment of urokinase and domain II of bikunin efficiently inhibits tumor cell invasion and metastasis. Eur J Biochem 1998 253 817-826. 

Shinohara H, Kobayashi H, Hirashima Y, Ohi H, Terao T. Urinary trypsin inhibitor (UTI) efficiently inhibits tumor cell invasion and metastasis in the experimental and spontaneous model. J Jpn Soc Cancer Ther 1996 3 186-195. 

T11. Tserotas, K., and Merino, G., Andropause and the ageing male. Arch. Andr. 40, 87-93 (1998). T12. Turner, T., Epps-Fung, M. V., Kassis, J., and Wells, A., Molecular inhibition of phospholipase c y signalling abrogates DU-145 prostate tumor cell invasion. Clin. Cancer Res. 3, 2275-2282... 

V2. Van Aswegen, C. H., and Du Plessis, D. J., A possible role for enzymes in tumor-cell invasion. 

Beside adhesion per se, tumor cell interactions with ECM components influence motility, invasiveness and many other important aspects of the metastatic tumor cell phenotype. Tumor cell motility and adhesion are, in fact, closely linked, thus implicating a role for tumor cell adhesion in invasion. Indeed, tumor cell invasion has been proposed to represent a three step process, involving tumor cell adhesion, release of ECM degrading enzymes and tumor cell... 

Boxberger, H. J., Paweletz, N., Spiess, E. and Kriehuber, R. (1989). An in vitro model study of BSp73 rat tumor cell invasion into endothelial monolayer. Anticancer Res. 9, 1777-1786. 

Hendrix, M. J. C., Seftor, E. A., Seftor, R. E. B., Misiorowski, R. L., Saba, P. Z., Sundareshan, P. and Welch, D. R. (1989). Comparison of tumor cell invasion assays human amnion versus reconstituted basement membrane barriers. Invasion and Metastasis 9, 278-297. 

Knox, J. D., Mack, C. R, Powell, W. C., Bowden, G. T. and Nagle, R. B. (1993). Prostate tumor cell invasion A comparison of orthotopic and ectopic models. Invasion Metastasis 13, 325-331. 

Li, L., Shin, D. M. and Fidler, I. J. (1990). Ectopic organ environment favors tumorigenicity and production of metastasis by Lewis Lung tumor cells. Invasion Metastasis 10, 129-141. 

Thorgeirsson, U. R, Turpeenniemi-Hujanen, T., Neckers, L. M., Johnson, D. W. and Liotta, L. A. (1984). Rrotein synthesis, but not DNA synthesis is required for tumor cell invasion in vitro. Invasion Metastasis 4, 73-84. 

A number of mechanisms have been suggested to explain the process of tumor cell invasion in terms of observed properties of neoplastic cells. One of these, that tumor invasion is the result of cellular multiplication and mechanical expansion, visualizes tumor infiltration as resembling the growth of a plant root. According to this theory, the pressure from a constantly increasing cell mass is thought to cause... 

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