Lactobacillus acidophilus

Lactobacillus acidophilus ATCC 4356 slpA slpB 444/24 456 (silent) O X89375 X89376... 

SWANSON K S, GRIESHOP C M, FLICKINGER E A, BAUER L L, WOLF B W, CHOW J, GARLEB K A, WILLIAMS J A, FAHEY G c Jr (2002b) FructooUgosaccharides and Lactobacillus acidophilus modify bowel function and protein catabolites excreted by healthy hmnans. J Nutr. 132 3042-50. 

Probiotics, such as Lactobacillus acidophilus or Bifidobacterium, may offer possible benefit, based on the rationale that modification of the host flora may alter the inflammatory response. Some evidence exists for improvement in disease symptoms, but further well-controlled trials are needed.26... 

Although study results are conflicting, the daily consumption of active Lactobacillus acidophilus may reduce recurrence. One study found that the daily ingestion of 8 ounces of yogurt produced a threefold reduction in the incidence of infection,8 while other studies found no difference in infection rates in women who ingested yogurt.9,10... 

Bees and ants are not the only critters that attack using acid. Bacteria, such as those found in plaque, do, too. Saliva usually keeps the mouth at a pH of about 6.8. Any pH of 6.0 or higher does not cause the teeth any problems. Plaque, a bacteria-containing film that builds up on teeth, can cause that pH to plummet. That is because it contains bacteria such as Streptococcus mutans, Lactobacillus casei, and Lactobacillus acidophilus that feed on sugars and make lactic acid. These conditions can lower the pH in the mouth to 5.5 or less. 

Laland SG, Serck-Hanssen G (1964) Synthesis of pyrimidin-2-one deoxyribosides and their ability to support die growth of the deoxyriboside-requiring organism lactobacillus acidophilus r26. Biochem J 90 76-81... 

Babinska I., Rotkiewicz T. and Otrocka-Domagala I. (2005). The effect of Lactobacillus acidophilus and Bifidobacterium spp. administration on the morphology of the gastrointestinal tract, liver and pancreas in piglets . Pol J Vet Sci, 8(1), 29-35. 

Gmeiner M., Kniefel W., Kulbe K.D., Wouters R., De Boever P., Nollet L. and Verstreate V. (2000). Influence of a synbiotic mixture consisting of Lactobacillus acidophilus 74—2 and a frue loo I i go s acc h ari dc preparation on the microbial ecology sustained in a simulation of the human intestinal microbial ecosystem (SHIME reactor) . Appl Microbiol Biotechnol, 53, 219-223. 

Kinouchi T, Kataoka K, Bing SR, Nakayama H, Uejima M, Shimono K, Kuwahara T, Aki-moto S, Hiraoka I, Ohnishi Y Culture supernatants of Lactobacillus acidophilus and Bifidobacterium adolescentis repress ileal ulcer formation in rats treated with a nonsteroidal antiinflammatory drug by suppressing unbalanced growth of aerobic bacteria and lipid peroxidation. Microbiol Immunol 1998 42 347-355. 

Lactobacilli used have included a commercial mixture of Lactobacillus acidophilus and Lactobacillus bulgaricus (Lactinex ) and Lactobacillus GG. decreased AAD in adults receiving amoxicillin (3.3%) compared to placebo (21%), but the difference was not statistically significant [69]. A study in children receiving amoxicillin failed to demonstrate a significant decrease in AAD with this probiotic mixture [70], Variability in lots may explain differences in efficacy in many trials [71], Lactobacillus GG may have a better efficacy than this probiotic mixture in... 

Several probiotic organisms have been shown to adhere to the intestinal mucosa (Jacobsen et ah, 1999). For example, Lactobacillus acidophilus... 

Bernet, M. F., Brassart, D., Neeser, J. R., and Servin, A. L. (1994). Lactobacillus acidophilus Lai binds to cultured human intestinal cell lines and inhibits cell attachment and cell invasion by enterovirulent bacteria. Gut 35, 483-489. 

Uchida, FI., Fujitani, K., Kawai, Y., Kitazawa, H., Horii, A., Shiiba, K., Saito, K., and Saito, T. (2004). A new assay using surface plasmon resonance (SPR) to determine binding of the Lactobacillus acidophilus group to human colonic mucin. Biosci. Biotechnol. Biochem. 68, 1004 1010. 

Lactobacillus acidophilus (strain R-26, heterodimeric enzyme, deoxyadenosine kinase/deoxguanosine kinase [16]) [16, 17, 18]... 

Hong, Y.S. Ma, G.T. Ives, D.H. Directed mutagenesis of deoxyguanosine site at arginine 79 up-regulates turnover on deoxyadenosine kinase subunit of heterodimeric enzyme from Lactobacillus acidophilus R26. J. Biol. Chem., 270, 6602-6606 (1995)... 

Acidophilus milk is a sharp, harsh, acidic cultured milk produced by fermenting whole or skim milk with active cultures of Lactobacillus acidophilus. Honey, glucose, and tomato juice may be added as nutrients to stimulate bacterial growth and contribute flavor. Plain acidophilus milk has the same composition as whole milk or skim milk, except that part of its lactose is converted to 0.6 to 1% lactic acid by the culture organisms. Speck (1976), who proposed the addition of L. acidophilus to pasteurized milk (sweet acidophilus milk), described the beneficial effects of implanting the organisms in the human intestines. 

Goldin, B. R. and Gorbach, S. L. 1980. E ffect of Lactobacillus acidophilus dietary supplements on 1,2-dimethylhydrazine dihydrochloride-induced intestinal cancer in rats. J. Natl. Cancer Inst. 64, 263-265. 

Marshall, V. M. and Cole, W. M. 1983. Threonine aldolase and alcohol dehydrogenase activities in Lactobacillus bulgaricus and Lactobacillus acidophilus and their contribution to flavour production in fermented foods. J. Dairy Res. 50, 375-379. 

Vincent, J. G, Veomett, R. C. and Riley, R. F. 1959. Antibacterial activity associated with Lactobacillus acidophilus. J. BacterioL 78, 477-484. 

Catalanotti, P., et al. 1994. Effects of cetylmethylammonium naproxenate on the adherence of Gardnerella vaginalis, Mobiculunus curtisii and Lactobacillus acidophilus to vaginal epithelial cells. Sex Transm Dis 21 338. 

Some bacteria, such as the lactobacillus acidophilus found in yogurt, also carry out lactic acid fermentation. It is the presence of lactic acid in yogurt that gives it its sour taste. 

Wheeler, J.G., Shema, S., Bogle, M.L. etal. 1997b. Immune and clinical impact of Lactobacillus acidophilus on asthma. Ann Allergy Asthma Immunol 79 229-233. 

---