Tumour cell invasion

Sahai E, Marshall CJ (2003) Differing modes of tumour cell invasion have distinct requirements for Rho/ROCK signalling and extracellular proteolysis. Nat Cell Biol 5 711-719... 

Nystrom ML, Thomas GJ, Stone M et al (2005) Development of a quantitative method to analyse tumour cell invasion in organotypic culture. J Pathol 205 468-475... 

The same workers found the corresponding L-iduronic acid congener (87) to be a moderate inhibitor of )3-glucuronidase from human liver (K 1.3 pmol/1). The sodium salt of glucaro- lactam and strucural analogues thereof were recently reported to be potent inhibitors of pulmonary metastases and tumour cell invasion [138]. 

Price, L.S. and Collard, J.G. (2001) Regulation of the cytoskeleton by Rho-family GTPases implications for tumour cell invasion. Semin.Cancer Biol., 11, 167-173. 

Kinsella AR, Green B, Lepts GC, et al. The role of cell-cell adhesion molecule E-cadherin in large bowel tumour cell invasion and metastasis. Br J Cancer. 1993 67 904-909. 

Grimshaw, M. J. 2005. Endothelins in breast tumour cell invasion. Cancer Lett 222 129-138. 

Friedl, P. and Wolf, K., Tumour-cell invasion and migration Diversity and escape mechanisms, Nat. Rev. Cancer, 3, 362-374, 2003. 

Boxberger HJ, Paweletz N, Spiess E, Kriehuber R. An in vitro model study of BSp73 rat tumour cell invasion into endothelial monolayer. Anticancer Res 1989 9 1777-1786. 

Siegert, A., Rosenberg, C., Schmitt, W.D., Denkert, C., and Hauptmann, S. (2002). Nitric oxide of human colorectal adenocarcinoma cell lines promotes tumour cell invasion. Br. J, Cancer 86, 1310-1315. 

Cat B is an abundant and ubiquitously expressed cysteine peptidase of the papain family and makes up a major fraction of lysosomal enzymes that is capable of degrading components of the extracellular matrix in various diseases [30-32]. Cat B is also a prognostic marker for several types of cancer [33], and increased expression and secretion of cat B has been shown to be involved in the migration and invasion of various tumours [34—36], The precise role of cat B in solid tumours is not fully understood, but it has been proposed to participate, along with other cysteine cathepsins, in metastasis, angiogenesis, and tumour progression [37], Indeed, cat B inhibitors reduce both tumour cell motility and invasiveness in vitro [38], Recently, metal complexes based on rhenium, gold and palladium were shown to be effective inhibitors of cat B [39-44],... 

Figure 13.1. Macroscopic and microscopic appearance of solid tumours, a A metastasis of an intestinal tumour in the liver. The tumour is the bright blob ins the center, showing irregular tissue organization, and yellowish fat deposits and cavities resulting from cell degeneration. The tumour grows invasively into the surroimding liver tissue, b Microscopic picture of a malignant epithelial (squamous cell) tumour. Note the very irregular size and shape of nuclei and of cells.

Keely, P., Parise, L. and Juliano, R. (1998). Integrins and GTPases in tumour cell growth, motility and invasion. Trends Cell Biol. 8, 101-106. 

Potter, K. M., Juacaba, S. R, Price, J. E. and Tarin, D. (1983). Observations on organ distribution of fluoroscein-labelled tumour cells released intravascularly. Invasion Metastasis 3, 221-233. 

Although at the present time, relatively little is known regarding the signalling pathways activated by chemokines in cancer cells, preliminary data show that CXCR4 and CCR7 are capable of activating a number of different intracellular events such as chemotaxis, invasion and adhesion, all of which are properties that correlate with metastatic behaviour of tumour cells [40, 95]. 

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