Renal carcinoma

Glucocorticoids have inhibitory (apoptotic) effects on lymphocyte proliferation and are used to treat leukemias and lymphomas. Estrogens (fosfestrol) are used to block the effect of androgens in prostate cancer. Progestogens (megestrol, medroxyprogesteroneacetate) have been useful for treating endometrial carcinoma, renal tumors, and breast cancer. [Pg.155]

It is used for the treatment of non small cell lung carcinoma, breast carcinoma, Hodgkin s disease, ovarian carcinoma, squamous cell carcinoma of the head and neck, cervical squamous cell carcinoma, renal cell cancer and Kaposi s sarcoma. [Pg.377]

Extrabladder tumors Prostatic carcinomas Renal tumors Seminomas Perineal sarcomas Osteosarcomas... [Pg.82]

K-RAS Lung adenocarcinoma Colon carcinoma Ovarian carcinoma Gastric carcinoma Renal cell carcinoma Acute myelogenous leukemia Pancreatic ductal adenocarcinoma... [Pg.454]

Carcinomas that are almost invariably negative but may occasionally show rare CK7-positive cells include hepatocellular carcinomas, duodenal ampullary carcinomas, colon carcinomas, renal (clear cell type), prostate, and adrenal cortical tumors. [Pg.214]

RCC marker (renal cell carcinoma) Renal Membranous... [Pg.372]

Pan CC, Chen PC, Tsay SH, Ho DM. Differential immuno-profiles of hepatocellular carcinoma, renal cell carcinoma, and adrenocortical carcinoma a systemic immunohistochemical survey using tissue array technique. Appl Immunohistochem MolMorphol. 2005 13 347-352. [Pg.591]

Liu L, Qian J, Singh H, et al. Immunohistochemical analysis of chromophobe renal cell carcinoma, renal oncocytoma, and clear cell carcinoma an optimal and practical panel for differential diagnosis. Arch Pathol Lab Med. 2007 I31 I290. [Pg.657]

Selection of a number of cases from patient subsets in a given microarray slide is amenable to statistical modeling to enhance analysis of results. Different microarrays can be constructed to answer different scientific questions. The microarrays can also be produced from archival material, using paraffin blocks of already characterized tumors with clinical follow-up. This would provide a rapid evaluation of clinically well-characterized tumors. The viability of this approach has been tested with prostate carcinomas, renal cell carcinomas, and other tumors (5,6). [Pg.93]

Cytokeratin 8 (CK8) Adenocarcinoma of lung, GIT, pancreas, biliary tract, breast, endometrium, transitional cell carcinoma, hepatocellular carcinoma, renal cell carcinoma, neuroendocrine Leiomyosarcoma Epithelium of GIT, salivary glands, biliary tract, pancreas, lung, female genital tract, hepatocytes, proximal renal tubules, transitional epithelium, mesothelial cells, smooth muscle cells, myofibroblasts, arachnoid cells... [Pg.65]

Adenocarcinoma of lung, GIT, pancreas, biliary tract, breast, endometrium, transitional cell carcinoma, hepatocellular carcinoma, renal cell carcinoma, neuroendocrine carcinoma... [Pg.66]

Renal cell carcinoma marker (RCC, gp200) Renal cell carcinoma (papillary carcinoma dear cell carcinoma) Parathyroid adenoma, breast carcinoma, embryonal carcinoma Renal proximal tubular brush border, epididymal tubular epithelium, breast parenchyma, thyroid follides... [Pg.70]

Of male Wistar rats that received 1% lead acetate in their diet for 1 year, 88% developed renal carcinoma (Boyland et al. 1962). Another experiment with Wistar rats that were fed lead subacetate in the diet found renal tumors in both the high-dose (1%) and low-dose (0.1%) groups (van Esch et al. 1962). Several later experiments in Wistar rats exposed via the diet to either lead subacetate or lead acetate also observed renal tumors (Mao and Molnar 1967 Zawirska and Medras 1968, 1972 Ito et al. 1971 Ito 1973 Waszynski 1977) many of these included observations of renal carcinoma. Renal tumors were also observed in different rat strains. For example, Sprague Dawley rats that received 1% lead... [Pg.157]

Agents which enhance the host s response against neoplasias or force them to differentiate are termed biological response modifiers. Examples include interleukin 2 which is used to treat renal cell carcinoma, interferon a which is active against hematologic neoplasias, and tretinoin (all-trans retinoic acid) which is a powerful inducer of differentiation in certain leukemia cells by acting on retinoid receptors. Side effects include influenza like symptoms, changes in blood pressure and edema. [Pg.156]

Interleukin 2 (Aldesleukin, Proleukin ) is a major growth factor and activator of cytotoxic and other T-lymphocytes. It is applied in the therapy of metastas-ing renal carcinoma and melanoma. Side effects include... [Pg.411]

Other malignancies Metastatic renal cell carcinoma ... [Pg.644]

Metastatic renal cell carcinoma has a poor prognosis and resists conventional chemotherapy. Immunotherapy with IL-2 and/or IFN-a is currently regarded as the most effective therapy with, however, modest response rates of 15-20%. Similar results are also observed in patients with metastatic melanoma and the response to IFN-a and IL-2 correlates with the occurrence of tumor-infiltrating CD4+ T-lymphocytes identified in aspirates from melanoma metastases. Determination of these cells therefore seems to be a method to predict responders prior to the initiation of cytokine therapy. [Pg.645]

S orafenib (Nexavar ) Bayer TKI VEGFR, PDGFR, KIT, FTL-3, RAF Unresectable or metastatic renal cell carcinoma... [Pg.1193]

IMOxine Agonist Renal cell carcinoma Phase II clinical trials... [Pg.1211]

CCI-779 - renal carcinoma, lymphoma AP23573 - sarcomas RAD-001 - pancreatic cancer Again, several preclinical studies suggest that rapalogs will have synergistic affects when used in combination with other chemotherapeutics. [Pg.1216]

Chin, K.V., Tanaka, S., Darlington, G., Pastan, 1., Gottesman, M.M. (1990). Heat shock and arsenite increase expression of the multi-drug resistanee (MDR1) gene in human renal carcinoma cells. J. Biol.Chem. 265,221-226. [Pg.452]

A. R. Tate, P. J. D. Foxall, E. Holmes, D. Molca, M. Spraul, J. K. Nicholson, J. C. Lindon 2000, (Distinction between normal and renal cell carcinoma kidney cortical biopsy samples using pattern recognition of H-l magic angle spinning (MAS) NMR spectra), NMR Biomed. 13, 64-71. [Pg.77]

Neoplasm (e.g., renal cell carcinoma and Wilms tumor)... [Pg.831]

Most kidney transplant procedures are heterotopic, where the kidney is implanted above the pelvic bone and attached to the patient s iliac artery and vein. The ureter of the transplant kidney is attached directly to the recipient s bladder or native ureter. The native kidneys usually are not removed, and data have shown that under most circumstances, removal of the native kidneys does not influence patient survival and allograft survival. Special circumstances, however, such as renal cell carcinoma and PCKD, may necessitate native kidney removal.1,3 There were 16,477 (9914 deceased donors, 6563 living donors) kidney transplants and 903 simultaneous kidney-pancreas procedures done in 2005.3... [Pg.831]

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