Papillary renal cell carcinoma

Fig. 3. Immunohistochemical expression of (a) hK7 by the epithelium of eccrine glands of the skin (monoclonal antibody, clone 73.2), (b) hK13 by the epithelium of the bronchus (monoclonal antibody, clone IIC1), (c) hK5 by the ductal epithelium of the parotid gland (polyclonal antibody), (d) hK7 by the esophageal glands (monoclonal antibody, clone 73.2), (e) hK13 by the gastric mucosa (monoclonal antibody, clone 2-17), (f) hK6 by the large intestine mucosa (polyclonal antibody), (g) hK10 in an islet of Langerhans in the pancreas (monoclonal antibody, clone 5D3), (h) hKll by the epithelium of the urinary tubuli (monoclonal antibody), (i) hKll by a papillary renal cell carcinoma (monoclonal antibody).

Bellon, S.F., Kaplan-Lefko, R, Yang, Y., et al (2008) c-Met inhibitors with novel binding mode show activity against several hereditary papillary renal cell carcinoma-related mutations./. Biol. Chem. 283, 2675-83. 

FIGURE 16.35 PAX8 immunoexpression in primary clear cell RCC (A), papillary renal cell carcinoma (B), chromophobe RCC (C), and metastatic clear cell RCC (D). 

Leroy X, Zini L, Leteurtre E, et al. Morphologic subtyping of papillary renal cell carcinoma correlation with prognosis and differential expression of MUCl between the two subtypes. Mod Pathol. 2002 15 1126. 

Delahunt B, Eble JN. Papillary renal cell carcinoma a clinicopathologic and immunohistochemical study of 105 tumors. Mod Pathol. 1997 10 537. 

Renshaw AA, Corless CL. Papillary renal cell carcinoma. Histology and immunohistochemistry. Am J Surg Pathol. 1995 19 842. 

Corless CL, Aburatani H, Fletcher JA, et al. Papillary renal cell carcinoma quantitation of chromosomes 7 and 17 by FISH, analysis of chromosome 3p for LOH, and DNA ploidy. Diagn Mol Pathol. 1996 5 53. 

Tretiakova MS, Sahoo S, Takahashi M, et al. Expression of al-pha-methylacyl-CoA racemase in papillary renal cell carcinoma. Am J Surg Pathol. 2004 28 69. 

Cossu-Rocca P, Eble JN, Delahunt B, et al. Renal mucinous tubular and spindle carcinoma lacks the gains of chromosomes 7 and 17 and losses of chromosome Y that are prevalent in papillary renal cell carcinoma. Mod Pathol. 2006 19 488. 

Paner GP, Srigley JR, Radhakrishnan A, et al. Immunohistochemical analysis of mucinous mbular and spindle cell carcinoma and papillary renal cell carcinoma of the kidney significant immunophenotypic overlap warrants diagnostic caution. Am J... 

Noteworthy is that the TEF3 gene is also involved in other specific genetic abnormalities associated with a portion of papillary renal cell carcinoma, namely both reciprocal translocations t(X l)(pll.2 q21.2) and t(X 17)(pll.2 q25), mainly described in pediatric renal cell carcinomas, which may indicate a genetic relationship between both tumor identities. 

As the t(X 17)(pll.2 q25) translocation was not detected in any other soft tissue tumor, the molecular detection of the specific fusion transcripts can be used as an additional diagnostic assay to confirm the diagnosis of alveolar soft part sarcoma, however we have to consider that similar genetic abnormalities may be associated primary and metastatic papillary renal cell carcinoma. 

Zbar B, Glenn G, Lubensky I, et al. Hereditary papillary renal cell carcinoma clinical studies in 10 families. J Urol 1995 153 907-912. 

Heimann P, El Housni H, Ogur G et al (2001) Fusion of a novel gene, RCC17, to the TFE3 gene in t(X 17)(pll 2 q25 3)-bearing papillary renal cell carcinomas. Cancer Res 61(10) 4130-4135... 

FIGURE 16.36 Carbonic anhydrase IX immunoexpression in clear cell renal cell carcinoma (A). Negative staining is encountered in papillary and chromophobe renal cell carcinoma (B and C, respectively). 

Jadallah S, Albadine R, Sharma RB, Netto GJ. PAX-8 Expression in Clear Cell, Papillary and Chromophobe RCC and Urothelial Carcinoma of Renal Pelvis. Mod Pathol. 2009 22 174A. 

Renshaw AA, Zhang H, Corless CL, et al. Solid variants of papillary (chromophil) renal cell carcinoma clinicopathologic and genetic features. Am J Surg Pathol. 1997 21 1203. 

Kattar MM, Grignon DJ, Wallis T, et al. Clinicopathologic and interphase cytogenetic analysis of papillary (chromophilic) renal cell carcinoma. Mod Pathol. 1997 10 1143. 

Moderate atypia and atypical hyperplasia of the urothelium were first described in 4 pieces of nephroureterectomies performed in 3 CHN patients prior or at time of transplantation [28]. Then, three cases of cancers of the urinary tract were reported the first case, a 28 year old woman with CHN, developed two papillary transitional cell carcinomas in the posterior bladder wall 12 months after a renal transplantation [31] the second case, a 42 year old woman with CHN, presented with hematuria secondary to a papillary transitional cell carcinoma of the right pelvis [32]. The third case was a 49 year old woman previously published as... 

CD9 Papillary (chromophile) renal cell carcinoma, clear cell renal cell carcinoma, Pre B-ALL, AML (M3) Astrocytoma, ovarian carcinoma, vascular tumors B-cells, plasma cells, activated T-ceUs, megakaryocytes/ platelets, macrophages, granulocytes, endodielial cells, brain, cardiac... 

Renal cell carcinoma marker (RCC, gp200) Renal cell carcinoma (papillary carcinoma dear cell carcinoma) Parathyroid adenoma, breast carcinoma, embryonal carcinoma Renal proximal tubular brush border, epididymal tubular epithelium, breast parenchyma, thyroid follides... 

Von Hippel-Lindau disease (VHL) is an autosomal dominant condition secondary to an alteration in a tumor suppressor gene on chromosome 3. It has incomplete penetrance and is characterized by hemangioblastomas in the retina, CNS, renal cell carcinoma, endolymphatic sac tumors, pheochro-mocytomas, papillary cystadenoma of the epididymis, angiomas of the liver and kidney, cysts of the liver, kidney and epididymis, and pulmonary arteriovenous shunts (Fig. 4.18a-c). In the pancreas, VHL may have multiple presentations, the most common being the presence of multiple small pancreatic cysts with calcifications in 40% of cases. Serous cystad-enomas, solid nonfunctional islet cell tumors, and adenocarcinoma are less common (Richard et al. 2004). 

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