Renal oncocytoma

CML, mast cell disease, renal oncocytoma, renal chromophobe carcinoma, thymic carcinoma, seminoma, gliomas... 

Stain Renal Cell Carcinoma Oncocytoma Hyalinizing Clear Cell Carcinoma Clear Cell Myoepithelioma... 

Ozolek JA, Bastacky S, Myers E, et al. Immunohistochemical staining characteristics of oncocytomas of major salivary glands comparison to conventional renal cell carcinoma. Laryngoscope. In press. 

Glutathione-transferase alpha (GST-a) protects cells by catalyzing the detoxification of xenobiotics and carcinogens. GST-a was recently found to be of diagnostic value in renal tumors. On the basis of cDNA microarray findings, immunohistochemical studies have so far shown GST-a to be highly expressed in CCRCC (90%) but not in ChRCC or oncocytomas and only occasionally in PRCC. 

Oncocytomas are benign renal neoplasms characterized by a typical gross mahogany-brown color. Microscopically, the tumor is composed of islands of oncocytic cells with coarsely granular eosinophilic cytoplasm set in a typical edematous myxoid focally hyalinized Oncocytomas display round, vesicular. 

Oncocytoma-like angiomyolipomas have distinct granular eosinophilic cytoplasm, bringing the diagnosis of renal oncocytoma into the differential diagnosis. 

Liu L, Qian J, Singh H, et al. Immunohistochemical analysis of chromophobe renal cell carcinoma, renal oncocytoma, and clear cell carcinoma an optimal and practical panel for differential diagnosis. Arch Pathol Lab Med. 2007 I31 I290. 

Mazal PR, Exner M, Haitel A, et al. Expression of kidney-specific cadherin distinguishes chromophobe renal cell carcinoma from renal oncocytoma. Hum Pathol. 2005 36 22. 

Perez-Ordonez B, Hamed G, Campbell S, et al. Renal oncocytoma a clinicopathologic study of 70 cases. Am J Surg Pathol. 1997 21 871. 

Huo L, Sugimura J, Tretiakova MS, et al. C-kit expression in renal oncocytomas and chromophobe renal cell carcinomas. Hum Pathol. 2005 36 262. 

Pan CC, Chen PC, Chiang H. Overexpression of KIT (CD117) in chromophobe renal cell carcinoma and renal oncocytoma. Am J Clin Pathol. 2004 121 878. 

Paner GP, Lindgren V, Jacobson K, et al. High incidence of chromosome 1 abnormalities in a series of 27 renal oncocytomas cytogenetic and fluorescence in situ hybridization studies. Arch Pathol Lab Med. 2007 31 81. 

Meyer PN, Cao Y, Jacobson K, et al. Chromosome 1 analysis in chromophobe renal cell carcinomas with tissue microarray (TMA)-facilitated fluorescence in situ hybridization (FISH) demonstrates loss of lp/1 which is also present in renal oncocytomas. Diagn Mol Pathol. 2008 17 141. 

Adley BP, Papavero V, Sugimura J, et al. Diagnostic value of cytokeratin 7 and parvalbumin in differentiating chromophobe renal cell carcinoma from renal oncocytoma. Anal Quant Cytol Histol. 2006 28 228. 

Pan CC, Chen PC, Ho DM. The diagnostic utility of MOC31, BerEP4, RCC marker and CD 10 in the classification of renal cell carcinoma and renal oncocytoma an immunohistochemical analysis of 328 cases. Histopathology. 2004 45 452. 

Renal oncocytoma (with low molecular weight cytokeratins). 

Angiomyolipoma, cellular neurothekoma, dermatofibrosarcoma protuberans, renal oncocytoma and chromophobe carcinoma... 

In differential diagnosis of solid renal lesions, MRI and MDCT have similar advantages. The diagnosis of an angiomyoUpoma can be made with MDCT and MRI, whereas both modalities have limitations in oncocytomas. 

Figure 14.5 Multimodal nonlinear microscopic image of the border (dashed line) between a renal tumor (oncocytoma) and normal kidney tissue. Red CARS green TPF blue SGH.

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