Cancer tumor models

Frenkel, V., Etherington, A., Greene, M., Quijano, J., Xie, J., Hunter, F., Dromi, S., and Li, K. C. P. (2006), Delivery of liposomal doxorubicin (Doxil) in a breast cancer tumor model Investigation of potential enhancement by pulsed-high intensity focused ultrasound exposure, Acad. Radiol., 13,467-479. 

Storm, G., Roerdink, F. H., Steerenberg, P. A., De jong, W. H., and Crommelin, D. J. A. (1987). Influence of lipid composition on the antitumor activity exerted by doxorubicin-containing liposomes in a rat solid tumor model, Cancer Res., 47, 3366-3372. 

Mirabelli, C.K., Johnson, R.K., Sung, C.M., Faucetter, L., Muirhead, K. and Crooke, S.T. (1985) Evaluation of the in vivo antitumor activity and in vitro cytotoxic properties of auranofin, a coordinated gold compound, in murine tumor models. Cancer Research, 45, 32-39. 

These data summarized above suggest that PDT with fullerenes is not only possible in animal tumor models, but demonstrate the potential use of these compounds as PS for PDT of cancer. 

Bandak S, Goren D, Horowitz A, Tzemach D, Gabizon A. Pharmacological studies of cisplatin encapsulated in long-circulating liposomes in mouse tumor models. Anti-Cancer Drugs 1999 10 911-920. 

Depletion of JARIDIB inhibits proliferation of breast cancer cell lines and tumor growth in a syngeneic mouse mammary tumor model. 

The present results also point to differences between the mammary tumor model and the ACT model for evaluating the potential cancer protective effects of Se in broccoli. A previous study (17) showed that high-Se broccoli florets decreased the number of DMH-induced ACT. Similarly, in the present study high-Se broccoli sprouts decreased DMH-induced ACT, but low-Se broccoli sprouts alone did not have any effect (Table 3). In the mammary tumor model, however, broccoli alone, similar to garlic alone (3), reduced the number of tumors (Table 1). This contrasting effect could be the result of a difference between tumor and preneoplastic lesion models, a difference between carcinogens, or a difference between mammary and colonic tissues. 

In addition to in vivo studies in models of CML, BMS-354825 has also been studied in models of solid tumors. BMS-354825 was efficacious in head and neck squamous cell carcinoma and non-small cell lung cancer animal models [151]. Based on this activity, BMS-354825 has been advanced into clinical trials for the treatment of solid tumors. 

Akinaga S, Gomi K, Morimoto M, Tamaoki T, Okabe M (1991) Antitumor activity of UCN-01, a selective inhibitor of protein kinase C, in murine and human tumor models. Cancer Res 51 4888-4892... 

Rubio-Viqueira B, Hidalgo M (2009) Direct in vivo xenograft tumor model for predicting chemotherapeutic drug response in cancer patients. Clin Pharmacol Ther 85 217-221... 

Walter-Yohrling J, Pratt BM, Ledbetter S et al (2003) Myofibroblasts enable invasion of endothelial cells into three-dimensional tumor cell clusters a novel in vitro tumor model. Cancer Chemother Pharmacol 52 263-269... 

Tumor Models in Cancer Research, edited by Beverly A. Teicher, 2002 Tumor Suppressor Genes in Human Cancer, edited by David E. Fisher, 2001 Matrix Metalloproteinase Inhibitors in Cancer Therapy, edited by Neil J. Clendeninn and Krzysztof Appelt, 2001... 

Although manipulation of the host immune response in animal tumor models has at times yielded impressive therapeutic results, attempts to extend these results to human cancers generally have been disappointing. 

J. Leyton, J.R. Latigo, M. Perumal, H. Dhaliwal, Q. He, E.O. Aboagye, Early detection of tumor response to chemotherapy by 3 -deoxy-3 -[ F]fluorothymidine positron emission tomography The effect of cisplatin on a fibrosarcoma tumor model in vivo. Cancer Res. 65(10) (2005) 4202-4210. 

Bhide. Weak carcinogenic effect of masheri, a pyrolysed tobacco product, in mouse skin tumor models. J Cancer Res Clin Oncol 1989 115(2) 166-169. 

Another important factor associated with an accurate in vivo tumor model is the number of days separating cancer cell inoculation and the initiation of the anticancer conjugate treatment. For example, if the inoculation of the cancer cells and the start of treatment are on the same day, it is likely that the tumor model will not be accurate since the cancer cells would not be established in the host, i.e., the cancer is easily eradicated. However, if treatment with the anticancer conjugate begins many days following inoculation of the cancer cells into the host, the cancer will be well established and the efficacy of the model greatly enhanced. 

Takechi T, Nakano K, Uchida J et al. Anti-tumor activity and low intestinal toxicity of S-1, a new formulation of oral tegafur, in experimental tumor models in rats. Cancer Chemother Pharmacol 1997 39 205-211. 

Bhat KP, Lantvit D, Christov K, Mehta RG, Moon RC, Pezzuto JM. 2001. Estrogenic and antiestrogenic properties of resveratrol in mammary tumor models. Cancer Res 61 7456-7463. 

It was demonstrated that curcumin effectively inhibits tumor implantation and growth in a murine bladder tumor model [Anand et al., 2008]. Another study demonstrated that dietary curcumin treatment reduced risk for kidney cancer metastasis in rats [Frank et al., 2003]. 

---