Dietary curcumin

It was demonstrated that curcumin effectively inhibits tumor implantation and growth in a murine bladder tumor model [Anand et al., 2008]. Another study demonstrated that dietary curcumin treatment reduced risk for kidney cancer metastasis in rats [Frank et al., 2003]. 

In an in vivo study in rats, dietary curcumin with cisplatin modulated tumor marker indices of fibrosarcoma toward normal controls [Navis et al., 1999], Treatment with radiotherapy and curcumin resulted in enhanced tumor cell killing and reduced radioresistance in mice bearing fibrosarcoma, as indicated by the significant inhibition of radiation-induced ERK and NF-kB expression [Kumar Mitra and Krishna, 2004],... 

Frank N, Knauft J, Amelung F, Nair J, Wesch H, Bartsch H. 2003. No prevention of liver and kidney tumors in Long-Evans Cinnamon rats by dietary curcumin, but inhibition at other sites and of metastases. Mutat Res 523-524 127-135. 

Navis I, Sriganth P, Premalatha B. 1999. Dietary curcumin with cisplatin administration modulates tumour marker indices in experimental fibrosarcoma. Pharmacol Res 39 175-179. 

Somasundaram S, Edmund NA, Moore DT, Small GW, Shi YY, Orlowski RZ. 2002. Dietary curcumin inhibits chemotherapy-induced apoptosis in models of human breast cancer. Cancer Res 62 3868-3875. 

Tunstall RG, Sharma RA, Perkins S, Sale S, Singh R, Farmer PB, Steward WP, Gescher AJ. 2006. Cyclooxygenase-2 expression and oxidative DNA adducts in murine intestinal adenomas Modification by dietary curcumin and implications for clinical trials. Eur J Cancer 42 415-421. 

Garg R, Gupta S, Mara G. 2008. Dietary curcumin modulates transcriptional regulator(s) of phase I and phase II enzymes in benzo(a)pyrene-treated mice Mechanism of its anti-initiating action. Carcinogenesis 29 1022-1032. 

Dietary curcumin can alleviate dangerous secondary complications induced by diabetes. The beneficial effects of dietary curcumin on diabetic nephropathy are probably mediated through the hypolipidaemic effects of curcumin (Babu and Srinivasan, 1997). 

Curcumin has been proved to be an effective hypolipidaemic agent (Babu and Srinivasan, 1997). One study validated the role of dietary curcumin in maintaining healthy serum cholesterol levels in diabetic rats. Employing a high-cholesterol diet for the diabetic rats, curcumin exhibited a lowering of cholesterol and phospholipid in treated animals as compared with curcumin-free controls. Liver cholesterol, triglycerides and phospholipid elevated under diabetic conditions were lowered by dietary curcumin. Curcumin induces a... 

Accumulation of P-amyloid proteins in the brain is one of the hallmarks of Alzheimer s disease. Dietary curcumin at low dose (160ppm) and high dose (5000ppm) significantly lowered oxidized proteins and interleukin 1-P, a pro-inflammatory cytokine... 

Figure 11.4 Effect of dietary curcumin on catalytic activity of cyclooxygenase (COX) in colon.

There is growing evidence that dietary curcumin possesses chemopreventive potential against mammary cancer. Dietary administration of 1% turmeric or 0.5% eth-anolic extract of turmeric inhibited DMBA-induced mammary carcinogenesis during the initiation as well as the postinitiation phase of carcinogenesis. Singletary... 

Rao, C.V., Simi, B., and Reddy, B.S., Inhibition by dietary curcumin of azoxymethane-induced ornithine decarboxylase, tyrosine protein kinase, arachidonic acid metabolism and aberrant crypt foci formation in the rat colon. Carcinogenesis (London), 14, 2219, 1993. 

Huang, M.T., Deschner, E.E., Newmark, H.L., Wang, Z.-Y, Eerraro T.A., and Conney, A.H., Effect of dietary curcumin and ascrobyl pahnitate on azoxymethanol-induced colonic epithelial cell proliferation and focal areas of dysplasia. Cancer Lett., 64, 117, 1992. 

Tanaka, T, Makita, H., Ohnisih, M., Hirose, Y, Wang, A., Mori, H., Satoh K., Kara, A., and Ogawa, H., Chemoprevention of 4-nitroquinoline 1-oxide-induced oral carcinogenesis by dietary curcumin and hesperidin comparison with the protective effect of P-carotene, Cancer Res., 54, 4653, 1994. 

Babu, P.S. and Srinivasan, K., Influence of dietary curcumin and cholesterol on the progression of experimentally induced diabetes in albino rat. Mo/. Cell. Biochem., 152 (1), 13-... 

Singh, S.V. et al.. Mechanism of inhibition of benzo[a]pyrene-induced forestomach cancer in mice by dietary curcumin. Carcinogenesis, 19,1357,1998. 

Sharma S, Zhuang Y, Ying Z, Wu A, Gomez-Pinilla F (2009) Dietary curcumin supplementation counteracts reduction in levels of molecules involved in energy homeostasis after brain trauma. Neuroscience 161 1037-1044... 

Kempaiah RK, Srinivasan K (2006) Beneflcial influence of dietary curcumin, capsaicin and garlic on erythrocyte integrity in high-fat fed rats. J Nutr Biochem 17 471 78... 

---