Murine tumor model

Mirabelli, C.K., Johnson, R.K., Sung, C.M., Faucetter, L., Muirhead, K. and Crooke, S.T. (1985) Evaluation of the in vivo antitumor activity and in vitro cytotoxic properties of auranofin, a coordinated gold compound, in murine tumor models. Cancer Research, 45, 32-39. 

Comparative Antitumor Activity of Selected 4-Deacetyl vinblastine Amides against Several Murine Tumor Models... 

A recent study has utilized an in vivo murine tumor model expressing human HER-2 for evaluating potential HER-2 vaccines consisting of either full-length or variable subunits of HER-2 delivered in either protein or plasmid DNA form (discussed later) (Foy et al., 2001). The mechanism of protection elicited by plasmid DNA vaccination appears to be exclusively CD4-dependent and not CD8- or antibody-dependent, whereas the protection observed with intracellular domain protein vaccination requires both CD4 and CD8 T cells. However, the exact mechanism(s) responsible for immunity to DNA has not been elucidated. 

A. Sharma, E. Mayhew and R.M. Straubinger, Antitumor effect of Taxol-containing liposomes in a Taxol-resistant murine tumor model, Cancer Res. 53 (1993) 5877-5881. 

Kaul, G., and Amiji, M. (2004), Biodistribution and targeting potential of poly(ethylene glycol)-modified gelatin nanoparticles in subcutaneous murine tumor model, J. Drug Target, 12(9-10), 585-591. 

Immunosurveillance and destruction of cancer cells depend on the host immune system, as suggested by recent studies providing direct evidence to the role of cells of the immune system in the inhibition of spontaneous tumor growth [276], T-cell-mediated antitumor immunity was demonstrated in murine tumor models [277-279] as well as in human tumors [280-282]. It is widely accepted that CD4 and CD8 T cells are the major components of this response [283-285], although other cells play important roles in the immunosurveillance against cancer, as the natural killer (NK), NKl.l T (NKT) andy6 T cells [286-288]. 

Thiazole, triazole, tetrazole, pyrazole, imidazole analogues (the heteroaromatic ring replacing the stilbene core) were then prepared and tested for tubulin polymerization inhibitory activity using bovine brain tubulin cytotoxic activity against the colon 26 adenocarcinoma cancer cell line antitumor activity in the colon 26 murine tumor model. 

The pyrazole- and thiazole analogues of the 3 -deoxy-3 -amino-4 -methoxy Combretastatin A-4 showed potent antimitotic (IC50 3.0 pM and IC50 10 pM) activity. The former showed also a potent cytotoxic activity (IC50 8.4 nM ). Moderate antimitotic activity (IC50 3.0 pM) and weak cytotoxic activity was observed for a triazole derivative, whereas tetrazole ring confers potent antimitotic (ICso 2.0 pM) as well as cytotoxic activity. Compounds with potent cjdotoxicity were further evaluated in vivo in the Colon murine tumor model. The best antitumor activity in vivo, expressed as tumour growth suppression, was observed for the thiazole and tetrazole derivatives with values comparable to the ones observed for 3 -deoxy-3 -amino Combretastatin A-4 hydrochloride. 

Levin W, Chang RL, Wood AW, et al. 1984. High stereoselectivity among the optical isomers of the diastereomeric bay-region diol-epoxides of benz(a)anthracene in the expression of tumorigenic activity in murine tumor models. Cancer Res 44 929-933. 

Nelson, C.A., Wang, J.Q., Leav, I., and Grane, P. D. The interaction among glucose transport, hexokinase, and glucose-6-phosphatase with respect to 3H-2-deoxyglucose retention in murine tumor models. Nucl. Med. Biol., 23 533-541, 1996. 

The antitumor activity of saffron was also evaluated against a variety of murine tumor models. Ascites tumors were induced by i.p. transplantation of one million cells in mice and appeared in 7-14 days depending on the type of tumor cells used [82], Saffron was administered... 

B.W. Henderson, V.H. Fingar (1989). Oxygen limitation of direct tumor cell kill during photodynamic treatment of a murine tumor model. Photochem. PhotobioL, 49, 299-304. 

Another feature of tumors that can have a major impact on the distribution of targeted radiotherapeutics is tumor interstitial fluid pressure. Interstitial fluid pressure results in a pressure gradient that can inhibit the delivery of molecules from the plasma to the extracellular fluid in central regions of a tumor. Tliis pressure gradient is not present in normal tissues because they have a lymphatic system however, tumors do not, creating an additional barrier that must be overcome. Experimental evidence of an elevated interstitial pressure in murine tumor models has been reported by Boucher et al. (1990). As expected, the effect was most apparent at the tumor periphery. Using a mathematical model, the magnitude of this outward convection fluid flow was predicted to be 0.1-0.2 pm/s (Jain and Baxter 1988). 

R. Whelpton, A.T. Michael-Titus, S.S. Basra and M. Grahn, Distribution of temoporfin, a new photosensitizer for the photodynamic therapy of cancer, in a murine tumor model, Photochem. Photobiol., 1995, 61, 397-401. 

Baumann M, Suit HD, Sedlacek RS (1990b) Metastases after fractionated radiation therapy of three murine tumor models. Int J Radiat Oncol Biol Phys 19(2) 367-370... 

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