Mouse skin tumor

Meyer SA, Kim TW, Moser GL, et al. 1994. Synergistic interaction between the non-phorbol ester-type promoter mirex and 12-o-tetradecanoylphorbol-13-acetate in mouse skin tumor promotion. Carcinogenesis 15(1) 47-52. 

CN073 Lo, H. H., M. F. Locniskar, D. Bechtel, CN083 and S. M. Fischer. Effects of type and amount of dietary fat on mouse skin tumor promotion. Nutr Cancer 1994 ... 

Bhide. Weak carcinogenic effect of masheri, a pyrolysed tobacco product, in mouse skin tumor models. J Cancer Res Clin Oncol 1989 115(2) 166-169. 

O Connell, J.F., Klein-Szanto, A.J.P, DiGiovanni. D.M.. Fries, J.W. Slaga, T.J. (1986) Enhanced malignant progression of mouse skin tumors by the free-radical generator benzoyl peroxide. Cancer Res., 46, 2863-2865... 

Soyasapogenol B, soyasaponins I and II and wistariasaponins from Wistaria brachybotrys (wistariasaponin C corresponds to astragaloside VIII) decreased (20-30%) the Epstein-Barr Virus (EBV) activation induced by the tumor promoter TPA (12-O-tetradecanoylphorbol-13-acetate) in Raji cells at a concentration of lxlO2 mol ratio [151]. Soyasaponin I from the same plant exhibited remarkable inhibitory effects on mouse skin tumor promotion on the basis of the two-stage DMBA-TPA carcinogenesis test in vivo. Soyasaponin I reduced the number of papillomas per mouse at about 40% even at 20 weeks [152]. 

Nesnow, S., Triplett, L. L., and Slaga, T. J. (1983). Mouse skin tumor initiation-promotion and complete carcinogenesis bioassays Mechanisms and biological activities of emission samples. Environ Health Perspect 47, 255-268. 

Ronai, Z.A., Gradia, S., el-Bayoumy, K., Amin,S.,andHecht,S.S.(1994)Con-trasting incidence of ras mutations in rat mammary and mouse skin tumors induced by onti-benzo[c]phenanthrene-3,4-diol-l, 2-epoxide. Carcinogenesis,... 

Krieg P, Kinzig A, Ress-Loschke M, Vogel S, Vanlandingham B, Stephan M, Lehmann WD, Marks F, Furstenberger G. 12-Lipoxygenase isoenzymes in mouse skin tumor development. Mol Carcinog. 14 (1995) 118-129. 

Many compounds that inhibit EBV-EA induction by TPA have been shown to act as inhibitors of tumor promotion in vivo [28]. Soyasaponin I (26) exhibited remarkable inhibitory effects on mouse skin tumor promotion on the basis of the two stage (DMBA-TPA) carcinogenesis... 

As already shown, tubeimoside 1 (5) from Bobolstemma paniculatum exhibited a strong anti-tumor activity, but had intriguingly a potent antitumor-promoting effect in two-stage mouse skin tumor formation induced by DMBA+TPA [38]. Its natural analog, tubeimoside III showed also a potent anti-tumor-promoting effect in the same model after topical administration but not after oral administration [39]. 

Active as inhibitor on two stage carcinogenesis test of mouse skin tumors induced by nitric oxide donor (NOR 1) and TPA. [44]... 

In a similar screening, Konoshima et al. [72] studied the inhibitory effects of twenty-four 29-nor-cucurbitacin glucosides isolated from the roots of Cayaponia tayuya and found that five of them, cayaponosides B, B3, D, D3b, and C2, exhibited significant inhibitory effects on EBV activation induced by the tumor promoter TPA. Moreover, two of the cucurbitacins shown to be active in vitro, cayaponosides B and C2, Fig. (14), inhibited mouse skin tumor promotion in a two-stage in vivo carcinogenesis test. 

Viaje, A., T.J. Siege, M. Wigler, and LB. Weinstein Effects of anti-inflammatory agents in mouse skin tumor promotion, epidermal DNA synthesis, phorbol ester-induced cellular proliferation, and production of plasminogen activator Cancer Res. 37 (1977) 1530-1536. Viart, P. Aromatization of tobacco. Determination of coumarin, dihydrocoumarin, ethylvanUhn and vanillin in tobacco and its smoke Aim. Dir. Emdes Equipement, SETTA 8(Sect. 1) (1970) 151-152. 

And, many compounds which showed strong inhibitory effects on the induction of EBV-EA by TPA have been shown to act as inhibitors of tumor promotion on two-stage carcinogenesis test in vivo [15-21, 27-29]. The one of two-stage carcinogenesis test is on mouse skin tumors induced by 7,12-dimethylbenz[a]anthracene (DMBA) as an initiator and TPA as a... 

Fig. (3). Method of in vivo two-stage carcinogenesis test on mouse skin tumors.

Furthermore, it was demonstrated that afromosin (21) enhanced the inhibitory effects of the saponin, which was also major constituent of W. brachybotrys, on mouse skin tumors as described as following section. 

Further, 39 showed the remarkable inhibitory effects on in vivo two-stage carcinogenesis of mouse skin tumor. In the tested group treated with 39, only 40% of mice bore papillomas at 10 weeks of promotion and 60% of mice bore papillomas at 17 weeks of promotion, and about 2 papillomas were formed per mouse at 10 weeks of promotion and only about 6 papillomas were formed per mouse after 20 weeks of promotion. 

Because the anti-tumor-promoting activity in vivo would be expected on the basis of these in vitro results, the inhibitory effects of 46 and 47 on the two-stage carcinogenesis of mouse skin tumors were investigated. As shown in Fig. (7), on the positive control, 55, 90 and 100% of mice bore... 

Belman S, Solomon J, Segal A, Block E, Barany G. Inhibition of soybean lipoxygenase and mouse skin tumor promotion by onion and garlic components. J Biochem Toxicol 1989 4 151-160. 

Arora, A. and Shukla, Y., Induction of apoptosis by diallyl sulfide in DMBA-induced mouse skin tumors, Nutr. Cancer, 44, 89,2002. 

The results of in vitro assay strongly suggested that P. notoginseng might be valuable antitumor-promoters. The method of in vivo two-stage carcinogenesis test on mouse skin tumor is shown in Figure. 2... 

Figure 2. Method of In vivo Two-Stage Carcinogenesis Test on Mouse Skin Tumor...

Konoshima, T., Takasaki, M., Kozuka, M., and Tokuda, H., Anti-tumor-promoting activities of kampo prescriptions. II, Inhibitory effects of Shouseiryu-to on two-stage carcinogenesis of mouse skin tumors and mouse pulmonary tumors. Yakugaku Zasshi, 114, 248 (1994), and references cited there in. 

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