Cancer ginseng

Yun TK (2001). Panax ginseng A non-organ-specific cancer preventive Lancet Oncology, 2, 49-55. 

Yun, Y.S. et al., Effect of red ginseng on natural killer cell activity in mice with lung adenoma induced by urethan and benzo(a)pyrene, Cancer Detect Prev Suppl, 1, 301, 1987. 

Finally, it has been shown that maturation of DCs is promoted by metabolized ginsenosides such as compound K. Takei et al (2004) showed that mature DCs differentiated with compound K enhance the differentiation of naive T cells toward the Thl t) e depending on lL-12 secretion, which clearly suggests that compound K has immunostimulatoty effects and that this compound is involved in the cancer preventive effects of ginseng and that compound K may be used on DC-based vaccines for cancer immunotherapy (Takei et al, 2004). 

Shibata, S. (2001). Chemistry and cancer preventing activities of ginseng saponins and some related triterpenoid compounds. /. Korean Med. Sci. 16(Suppl.), S28-S37. 

Wang, W., Zhao, Z.-J., Rayburn, E. R., HiU, D. L., Wang, H., and Zhang, R. (2007). In vitro anti-cancer activity and structure-activity relationships of natural products isolated from fruits of Panax ginseng. Cancer Chemother. Pharmacol. 59,589-601. 

Yun, T. K. (2003). Experimental and epidemiological evidence on non-organ specific cancer preventive effect of Korean ginseng and identification of active compounds. Mutat. Res. 523/524, 63-74. 

Prostate cancer effect. Saw palmetto, vitamin E, and selenium supplements were used by 26.5% of the questioned men diagnosed with prostate cancer . PC-SPES, an herbal mixture of chrysanthemum, isatis, licorice, Ganoderrm lucidum, Panax pseudo-ginseng, Rabdosia rubescens, saw palmetto. 

Chinese hamster ovary cells overexpressing the prolactin receptor, was active . Protein synthesis stimulation. Sterol fraction of the extract, in cell culture at a concentration of 25 (xg/mL, produced weak activity on CA-LNCAP. A concentration of 50 (xg/mL was active on CA-PC3 h PSA production inhibition. Ethanol (70%) extract of PC-SPES (a Chinese herb combination of chrysanthemum, dyers woad, licorice, reishi, san-qi ginseng, rabdosia, saw palmetto, and baikal skullcap), in cultured prostate cancer cell line at variable doses for 24 hours, produced a significant effect in supressing cell growth in all the cell lines h... 

Further, ginseng constituents are polysaccharides, essential oil constituents, polyacetylenes, peptides, and other lipids (7). Ginseng is included in the pharmacopeias of several countries such as China, Germany, and the United Kingdom (113). Modern therapeutic claims refer to vitality, immune function, cancer, cardiovascular diseases, and sexual function (114,115). More than 500 studies have been published on the pharmacological activity of ginseng (7,80). 

Ginseng Panax ginseng Root of the ginseng plant Increase well-being reduce fatigue used in the treatment of cancer, diabetes, cardiovascular dysfunction, and various other diseases... 

Helms S. Cancer prevention and therapeutics Panax ginseng. Altem Med Rev. 2004 9 259-274. 

Throughout history, the root has been used as a treatment for asthenia, atherosclerosis, blood and bleeding disorders, colitis, and relief of symptoms associated with aging, cancer, and senility. Ginseng is also widely believed to be an aphrodisiac. It is promoted as a tonic capable of invigorating the user physically, mentally, and sexually. It is also said to have antistress activity (see Chapter 60 and page 95). 

Shibata S, Fujita M, Itokawa H, Tanaka O. Studies on the constituents of Japanese and Chinese crude drugs. XL Panaxadiol, a sapogenin of Ginseng roots. Chem. Pharm. Bull. 1963 1 759. Shibata S. Chemistry and cancer preventing activities of ginseng saponins and some related triterpenoid compounds. J. Korean Med. Sci. 2001 16(suppl S) S28-S37. 

Tanaka O. Ginseng and its congeners - Traditional oriental food drugs. In Food Phytochemicals for Cancer Prevention II, ACS Symposium Series 1994 547 335-341. 

Yun TK, Choi SY. The relationship between cancer and ginseng intake. Inti. J. Epidemiol. 1990 19 871-876. 

The petroleum ether extract of Panax ginseng has antiproliferative effects on various cancer cell lines (murine sarcoma, murine leukaemia, human colon carcinoma, etc ). Polyacetylenic compounds from this extract such as panaxynol, panaxydol (46) and panaxytriol have been reported to be responsible for these effects [112, 113]. In order to identify the molecular mechanism of the polyacetylene compounds, one of the major cytotoxic compounds, panaxydol, was examined to see if it is able to disrupt cell cycle-related events. It was observed that panaxydol induces cell cycle arrest at Gi-S transition in SK-MEL-1 cells. This effect is related to the decreased Cdk2 activity, which seems to be caused by the increased level of p27 protein expression. The protein synthesis inhibitor cycloheximide reversed the growth suppression induced by panaxydol (80 j,g/ml) by... 

Xiaoguang C, Hongyan L, Xiaohong L, et al. Cancer chemopreventive and therapeutic activities of red ginseng. J Ethnopharmacol 1998 60 71-78. 

Yun TK. Experimental and epidemiological evidence of the cancer-preventive effects of Panax ginseng C.A. Meyer. Nutr Rev 1996 54(11 Pt 2) S71—S81. 

Block, K. and Mead, M. 2003. Immune system effects of Echinachea, Ginseng, and Astragalus A review. Integr. Cancer Ther. 2, 247-267. 

Siegel, R. 1979. Ginseng abuse syndrome Problems with the panacea. JAMA 241, 1614-1615. Siegers, C. 1992. Anthranoid laxatives and colorectal cancer. Trends Pharmacol. Sci. 13, 229-231. Simpson, E., Law, S., and Storrs, F. 2004. Prevalence of botanical extract allergy in patients with contact dermatitis. Dermatitis 15, 67-72. 

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