Dose variable

Plus riccmnicnt j ni fait Pexpitience suivanti . Cinq cliiens recoivent des doses variables de congest ne. 

Systemic absorption of pulmonary-deUvered peptides and proteins has been the objective of many investigations [2]. The most successful work in this field is the development of insulin formulations for inhalation.These dosage forms might, in the near future, become a suitable alternative for the current subcutaneous injection of insulin that is used to obtain meal-time glucose control [3]. In spite of the strict requirements regarding dose variability for insulin, the pulmonary products under development seem to be as safe as the subcutaneous injections. 

Fourth, inhaling instead of taking pills can help avoid gastrointestinal tract problems such as poor solubility, low bioavailability, gut irritability, unwanted metabolites, food effects and dosing variability. 

Dali, M.M. Heran, C.L. Kaeppeli, M. Stetsko, P.I. Smith, R.L. Intra-oral (buccal/sublingual) bioavailablity of propranolol in conscious rabbits as a function of PH and dosing variables. Proceedings of the American Association of Pharmaceutical Scientists Annual Meeting, New Orleans, LA Nov 19-23, 1999,1394 Abstract Number 2559. 

Although clearance of S-warfarin by CYP2C9 is an important determinant of interindividual dosing variability, many other factors have been implicated in maintenance dose. Clearly, the amount of vitamin K in the diet has a substantial impact on both inter- and intraindividual dosing [30]. Diet may also account for clearance differences observed in different ethnic groups. Although the factors resulting in the observed differences have not been elucidated, clearance of warfarin was seen to be different between... 

It has been demonstrated that 25% of dose variability could be explained by the patient s VKORCl SNP haplotype, which shows a strong correlation with their warfarin dosage requirement (low-, intermediate-, and high-dose)... 

Manufacturers will be aware of the potential unit dose variability within solid dose products generally, especially those having 5 mg or less of active ingredient per unit dose. Special procedures and controls should apply to lower doses because of the known difficulties in establishing and maintaining unit dose control. 

II. Toxic dose. Variable amounts of venom from none to the complete contents of the telson may be ejected through the stinger. 

Borgstrdm L, Asking L, Beckman O, Bondesson E, Kallen A. Olsson B. Discrepancy between in vitro and in vivo dose variability for a pressurized metered dose inhaler and a dry powder. J Aerosol Med 1998 11 S59-S64. 

Internal exposure Whole body activity Bioassay of excreta Limited to gamma emitters variability of intake rate requires metabolic data to convert activities to doses Variability of intake and excretion rate requires metabolic data to convert activity concentrations to doses... 

The meta-analysis of Pocock et al. (1994) addressed cross-sectional studies using both blood and dentine Pb measures as the dose variable. A statistically significant association was noted for 2-year PbB values and IQ decrements, but no relationships were reported for prenatal or perinatal PbB values. 

Antitumor - in vivo (IP, mouse), dose variable, tumor system not stated. 

Mutagenic - in vitro (cell culture, microsomes), dose variable. Frequent breaks at chromosome and chromatid 263... 

Liquid carbon dioxide is compressible which can make accurate dosing variable such that stable operating conditions may be difficult to achieve if dosing equipment does not allow for this. 

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