Bacillus Calmette-Guerin

Dead or live bacteria may be effective to stimulate inflammatory reactions of phagocytic cells against tumor cells. The best-characterized treatment is the use of Bacillus Calmette Guerin (BCG) in the case of bladder cancer where activation of the immune response is capable of controlling tumor growth. [Pg.616]

Otenhoff, T.H., Kale, A.B., VanEmbden, J.D.A., Thole, J.E.R., Kiessling, R. (1988). The recombinant 65-kD heat shock protein of Mycobacterium bovis bacillus calmette guerin/M. tuberculosis is a target molecule for CD4 + cytotoxic T lymphocytes that lyse human monocytes. J. Exp. Med. 168, 1947-1952. [Pg.458]

BCF Basophil chemotactic factor B-CFC Basophil colony-forming cell BCG Bacillus Calmette-Guerin BCNU l,3-bis(2-chloroethyl)-l-nitrosourea bFGF Basic fibroblast growth fiictor Bg Birbeck granules BHR Bronchial hyperresponsiveness BHT Butylated hydroxyroluene b.i.d. Bis in die (twice a day)... [Pg.279]

Intravesical infusion of linear PEI/pDNA polyplexes was evaluated in patients with superficial bladder cancer where intravesical therapy with bacillus Calmette-Guerin had failed [6, 224]. Patients had low grade superficial bladder cancer, which expressed H19. The therapeutic pDNA contains H19 gene regulatory sequences that drive the expression of an intracellular toxin. Escalating doses of 2-20 mg plasmid per intravesical treatment were applied, with responders continuing to receive polyplexes once a month every month for 1 year. The treatment resulted in complete ablation of the marker tumor, without any new tumors in four of the 18 patients (22% overall complete response rate). Eight of the 18 patients (44%) had complete marker tumor ablation or a 50% reduction of the marker lesion. [Pg.16]

Sidi AA, Ohana P, Benjamin S, Shalev M, Ransom JH, Lamm D, Hochberg A, Leibovitch I (2008) Phase I/II marker lesion study of intravesical BC-819 DNA plasmid in H19 over expressing superficial bladder cancer refractory to bacillus Calmette-Guerin. J Urol 180 2379-2383... [Pg.18]

BCG (bacillus Calmette-Guerin) vaccine Brucellosis vaccine Cholera vaccine Cytomegalovirus vaccines... [Pg.397]

Pinsky, C.M. et al., Intravesical administration of Bacillus Calmette-Guerin in patients with recurrent superficial carcinoma of the urinary bladder Report of a prospective, randomized trial, Cancer Treat. Rep., 69,47, 1985. [Pg.169]

Lage, J.M. et al., Histological parameters and pitfalls in the interpretation of bladder biopsies in Bacillus Calmette-Guerin treatment of superficial bladder cancer, J. Urol., 135, 916, 1986. [Pg.169]

Examples of attenuated vaccines are Bacillus Calmette-Guerin (BCG) for immunization against tuberculosis, Sabin vaccine for poliomyelitis, attenuated Paramyxovirus parotitidus against mumps, and attenuated measles virus against measles. [Pg.97]

Jouanguy, E., Lanhamedi-Cherradi, S., Altare, E, etal, Partial interferon-y receptor I deficiency in a child with tuberculoid bacillus Calmette-Guerin infection and a sibling with clinical tuberculosis. J. Clin. Invest. 100, 2658-2664 (1997). [Pg.265]

Live, attenuated bacteria, e.g. Bacillus Calmette-Guerin (BCG) used to immunize against tuberculosis. [Pg.436]

Bacillus Calmette-Guerin (BCG) and its active component, muramyl dipeptide, have been shown to have aspecific immunostimulant activity. It is mainly used for the local treatment of bladder cancer. It binds to fibronectine in the bladder epithelium. Hypersensitivity reactions and immune complex disease are its major adverse reactions. [Pg.469]

Bacillus Calmette-Guerin (BCG) is a viable attenuated strain of Mycobacterium bovis. Nonviable strains of the bacterium also have been shown to augment the immune response. The smallest active compound derived from BCG thus far has been identified as muramyl dipeptide. The T cell is a principal target for BCG. It also appears to stimulate natural killer cells, which in turn can kill malignant cells. It has been suggested that BCG cross-reacts immunologically with tumor cell antigens. [Pg.662]

BCG, live bacterium Mycobacterium bovis — Bacillus Calmette-Guerin... [Pg.502]

Lou, Y., Olson, W.P, Tian, X., Klegerman, M., and Groves, M.J. (1995). Interaction between fibronectin-bearing surfaces and Bacillus Calmette-Guerin (BCG) or gelatin microparticles. J. Pharm. Pharmacol., 47, 177-181. [Pg.240]

BCG [Bacillus Calmette-Guerin] (TheraCys, Tice BCG) Bevacizumab (Avastin) Bortezomib (Velcade) Cladribine (Leustatin) Dacarbazine (DTIC) Docetaxel (Taxotere) Gefldnib (Iressa)... [Pg.38]

Kremer, L., Riveau, G., Baulard, A., Capron, A. and Locht, C. (1996) Neutralizing antibody responses elicited in mice immunized with recombinant Bacillus Calmette-Guerin producing the Schistosoma mansoni glutathione S-transferase. The Journal of Immunology 156, 4309 1317. [Pg.321]

Zlotta, A. R., Noel, J-C, Fayt, I., Drowart, A., van Vooren, J.-P, Huggen, K., Simon, J., and Schulman, C. C. 1999. Correlation and prognostic significance of p53, p21 and Ki-67 expression in patients with superficial bladder tumors heated with bacillus-Calmette Guerin intravesicle therapy. J. Urol. 767 792-798. [Pg.350]

Parenteral 20 mg powder for IV injection BCG (Bacillus Calmette-Guerin) (Tice BCG)... [Pg.1359]

A15. Atkinson, J. P., and Frank, M. M., The effect of bacillus Calmette-Guerin-induced macrophage activation on the in vivo clearance of sensitized erythrocytes. J. Clin. Invest. 53, 1742-1749 (1974). [Pg.40]

Nyberg P, Klockars M. 1994. Bacillus Calmette-Guerin (BCG) and immunoglobulins synergistically enhance mineral dust-induced production of reactive oxygen metabolites by human monocytes. Clin Exp Immunol 97 334-337. [Pg.312]

Bacillus Calmette-Guerin (BCG) An attenuated strain of bovine tubercle bacillus, is available from Glaxo or from outdated hospital supplies as a lyophilized powder. Before use, it is suspended in sterile disdlled water. [Pg.36]

Bacillus Calmette-Guerin Pads (Shire) Bladder cancer immunotherapy... [Pg.276]

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