Reactive oxygen metabolites

Sun, F.F., Taylor, B.M. and Fleming, W.E. (1993). Formation of intracellular reactive oxygen metabolites during irreversible cell injury. FASEB J. 7, A658. 

Andrews, F.J., Malcontent , C. and O Brien, P.E. (1992). Sequence of gastric mucosal injury foUowing ischaemia and reperfusion the role of reactive oxygen metabolites. Dig. Dis. Sci. 37, 1356-1361. 

Davies, G.K, Simmonds, N.J., Stevens, T.R.J., Grandison, A., Revell, P., Blake, D.R. and Rampton, D.S. (1992a). Mucosal reactive oxygen metabolite production in duodenal ulcer disease. Gut 33, 1467-1472. 

Harris, M.L., Schiller, H.J., Reilly, P.M., Donowitz, M., Grisham, M.B. and Bulkley, G.B. (1992). Free radicals and other reactive oxygen metabolites in inflammatory bowel disease cause, consequence or epiphenomenon Pharmac. Ther. 53, 375-408. 

Haydek, J., Parveen, S., List, T., Doria, M. and Keshvarian, A. (1991). Reactive oxygen metabolites in experimental colitis the effect of catalase. Gastroenterology, 100, A585. 

Ito, Y., Hiraishi, H., Razandi, M., Terano, A., Harada, T. and Ivey, K.J. (1992). Role of cellular superoxide dismutase against reactive oxygen metabolite-induced cell dam e in cultured rat hepatocytes. Hepatology 16, 247-254. 

Keshavarzian, A., Doria, M.I., Sedghi, S., Kanofeky, J.R., Hecht, D., Holmes, E.W., Ibrahim, C., List, T., Urban, G., Gaginella, T. and Fields, J.Z. (1992a). Mitomycin C-induced colitis in rats a new animal model of acute colonic inflammation implicating reactive oxygen metabolites. J. Lab. Clin. Med. 120, 778-791. 

Keshavarzian, A., Zapeda, D., List, T. and Mobarhan, S. (1992d). High levels of reactive oxygen metabolites in colon cancer tissues analysis by chemiluminescence probe. Nutr. Cancer 17, 243-249. 

Rozga, J. (1989). The role of reactive oxygen metabolites in the pathogenesis of ulcerative colitis a speculative synthesis. Materia Med. Pol. 21, 263-268. 

Verspaget, H.W., Mulder, T.P.J., Van der Sluys Veer, A., Pena, A.S. and Earners, C.B.H.W. (1991). Reactive oxygen metabolites and colitis a disturbed balance between damage and protection. A selective review. Scand. J. Gastroenterol. 26 Suppl. 188, 44-51. 

In addition to the well-characterized role of iron in catalysing redox interactions, other metallic contaminants, for example, nickel, may also contribute. In vivo toxicity studies have demonstrated the capacity of nickel particulate compounds to induce tumours following intraperitoneal injection (Pott etal., 1987). Such activity is proportional to their phagocytic uptake, and to the associated respiratory burst and generation of PMN-derived reactive oxygen metabolites (ROMs), a proposed pathogenic mechanism (Evans et al., 1992a). 

Goodlick, L.A. and Kane, A.B. (1986). Role of reactive oxygen metabolites in crocidolite asbestos toxicity to mouse macrophages. Cancer Res. 46, 5558-5566. 

Yano, E., Urano, N. and Evans, P.H. (1991). Reactive oxygen metabolite production induced by mineral fibres. In Mechanisms in Fibre Carcinogenesis (eds. R.C. Brown, J.A. Hoskins and N.F. Johnson) pp. 433-438. Plenum, New York. 

Manna, C. et al. (1997). The protective effect of the olive oil polyphenol (3,4-dihydroxyphenyl)-ethanol counteracts reactive oxygen metabolite-induced cytotoxicity in Caco-2 cells. J. Nutr. 127(2) 286-292. 

The precise function of many acute-phase proteins is not known. C-reactive protein binds lipids, whilst a-macroglobulin and ceruloplasmin can scavenge some reactive oxygen metabolites. However, many acute-phase proteins are glycoproteins and can bind to bacterial surfaces hence, they may serve as non-specific opsonins for phagocytosis, and their synthesis is stimulated by IL-1 and IL-6. 

Apart from being a potent activator of neutrophil chemotaxis, IL-8 can also induce degranulation and reactive oxygen metabolite production in human neutrophils. These activities are usually very low or undetectable but are augmented when neutrophil suspensions are pretreated with cytochala-sin B. Addition of IL-8 also induces elevations in intracellular free Ca2+. 

The respiratory burst The generation of reactive oxygen metabolites and their role in microbial killing... 

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