Powder lyophilization

Powder, lyophilized 1.046 g ertapenem sodium (equivalent to 1 g ertapenem) Rx)... 

Powder Lyophilization Insulin Starch-Carbopol 974P, maltodextrin-Carbopol 974P In rabbits The highest absolute bioavailability obtained was 14.4% 46... 

Powder Lyophilization Ketorolac Microcrystalline cellulose In rabbits Significantly lower bioavailability of drug from powders compared to spray formulation 50... 

GRAS listed. Accepted in Europe as a food additive. Included in the FDA Inactive Ingredients Guide (IV injections, powder, lyophilized powder for liposomal suspension oral capsules, tablets, and topical preparations). Included in the Ganadian List of Acceptable Non-medicinal Ingredients. Included in nonparenteral medicines licensed in the UK. 

Purified hGH is a white amorphous powder in its lyophilized form. It is readily soluble (concentrations >10 mg/mL) in dilute aqueous buffers at pH values above 7.2. The isoelectric point is 5.2 (3) and the generally accepted value for the extinction coefficient at 280 nm is 17,700 (Af-cm) (4),... 

Lyophilization. LyophiLization is essentially a drying technology. Some dmgs and biologicals are thermolabile and/or unstable in aqueous solution. Utilization of freeze drying permits the production of granules or powders that can be reconstituted by the addition of water, buffered solution, or mixed hydrophilic solvents just prior to use, eg, certain antibiotic suspensions. 

Clinical Use. Vancomycin and teicoplanin as fomiulated dmgs are lyophilized powders to be reconstituted with sterile water for injection. Vancomycin hydrochloride [1404-93-9] is presented in vials of 500 mg that give 100—200 mL solution of pH 2.5—4.2. It is administered by slow (60 min) infusion at a dose of 500 mg every 6 h or 1 g every 12 h/d. The teicoplanin contains the five factors (87%) plus 13% of the pseudoaglycone T-A3-1. It is presented in vials containing 200 mg of lyophili ed power that after dissolution with 3 mL of solvent gives a solution at pH 7.5. The dose regimen is 200—800 mg/d by iv bolus adrninistration. 

Technetium-99m oxidronate is a bone imaging agent used to demonstrate areas of altered osteogenesis. It is rapidly cleared from the blood and taken up in areas of bone that are undergoing osteogenesis. The kit is a vial containing a lyophilized powder where sodium oxidronate is the active... 

Extraction of lyophilized protein powder by w/o-ME solution (solid-phase extraction method, SPE). 

IgE monoclonal antibody Lyophilized powder for reconstitution with sterile Dosed every 2 or 4 weeks based on patient weight and ... 

Drug Matrix. To 1.0 g of resin was added a 2.5 to 5.0 mL portion of a drug concentrate in water or ethanol. The slurry was mixed for one hour, at which time most of the solution had been absorbed by the powder. The solvent was removed by lyophilization (water) or by vacuum drying at 35°C (ethanol). The resultant matrix may be used as is, reground or tableted. 

The degradation of proteins in the solid state occur to a lesser extent and typically via different mechanisms than those that occur in solution [109,110]. Lyophilization is currently the more common technique in the manufacture of dried therapeutic proteins however, there is increasing interest in the use of spraydrying, owing to the unique physical nature of the spray-dried powder and its potential usefulness in protein drug delivery. 

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