Bacillus calmette-guerin tuberculosis

Otenhoff, T.H., Kale, A.B., VanEmbden, J.D.A., Thole, J.E.R., Kiessling, R. (1988). The recombinant 65-kD heat shock protein of Mycobacterium bovis bacillus calmette guerin/M. tuberculosis is a target molecule for CD4 + cytotoxic T lymphocytes that lyse human monocytes. J. Exp. Med. 168, 1947-1952. 

Examples of attenuated vaccines are Bacillus Calmette-Guerin (BCG) for immunization against tuberculosis, Sabin vaccine for poliomyelitis, attenuated Paramyxovirus parotitidus against mumps, and attenuated measles virus against measles. 

Jouanguy, E., Lanhamedi-Cherradi, S., Altare, E, etal, Partial interferon-y receptor I deficiency in a child with tuberculoid bacillus Calmette-Guerin infection and a sibling with clinical tuberculosis. J. Clin. Invest. 100, 2658-2664 (1997). 

Live, attenuated bacteria, e.g. Bacillus Calmette-Guerin (BCG) used to immunize against tuberculosis. 

Latini JM, Wang DS, Forgacs P, Bihrle W 3rd. Tuberculosis of the penis after intravesical Bacillus Calmette-Guerin treatment. J Urol 2000 163(6) 1870. 

Tuberculosis can be prevented by using the Bacillus Calmette-Guerin (BCG) tuberculosis vaccine, a weakened form of the tuberculosis bacterium that does not cause a tuberculosis infection. The vaccine enables the immune system to create antibodies for tuberculosis bacterium. 

The booster effect occurs in patients who do not respond to an initial skin test but show a positive reaction if retested about a week later. Patients with past M. tuberculosis infection and some patients with past immunization with bacillus Calmette-Guerin (BCG) vaccine or past infection with other mycobacteria may boost with a second skin test. Individuals who require periodic skin testing, such as health care workers, should receive a two-stage test initially. Once they are shown to be skin-test-negative, any positive skin test later shows recent infection, and this requires treatment. 

Of perhaps special interest are Micobacterium tuberculosis toxins, for which a vaccine has been developed known by the name Bacillus Calmette-Guerin (BCG), derived from Microbacterium bovis. 

We mention again Nieper anticancer therapy as profiled, for instance, by Richard Walters [1993]. Described as a complex nutritional and metabolic therapy, it variously involves vitamins, minerals, laetrile, animal and plant extracts, pharmaceuticals, and vaccines such as that called BCG, for bacillus Calmette-Guerin, a weakened strain of tuberculosis bacillus. The latter has entered medical orthodoxy as a treatment for bladder cancer.)... 

Bacillus Calmette-Guerin (BCG) Vaccine This BCG vaccine (0.1 mL intradermally) is indicated in conditions where an individual has been exposed to tuberculosis, where immunity is not permanent. 

Rainwater, D.L., and P.E. Kolattukudy Fatty acid biosynthesis in Mycobacterium tuberculosis var. bovis Bacillus Calmette-Guerin. J. Biol. Chem. 260, 616 (1985). 

Currently available live vaccines include measles, mumps, polio, rubella, vaccinia (smallpox), varicella (chickenpox), and yellow fever. All of these are made from viruses. There are two live bacterial vaccines 1) Bacillus of Calmette and Guerin (BCG) vaccine for tuberculosis and 2) oral typhoid. 

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