Antiadhesion

These aqueous emulsions can also be used to size paper for improving its water repeUency and antiadhesion properties (529). An increased level of organic titanate can be used to ensure the rapid curing (<5 s) for fast-paced paper or fiber curing operations (519). 

Some authors have suggested the use of fluorene polymers for this kind of chromatography. Fluorinated polymers have attracted attention due to their unique adsorption properties. Polytetrafluoroethylene (PTFE) is antiadhesive, thus adsorption of hydrophobic as well as hydrophilic molecules is low. Such adsorbents possess extremely low adsorption activity and nonspecific sorption towards many compounds [109 111]. Fluorene polymers as sorbents were first suggested by Hjerten [112] in 1978 and were tested by desalting and concentration of tRN A [113]. Recently Williams et al. [114] presented a new fluorocarbon sorbent (Poly F Column, Du Pont, USA) for reversed-phase HPLC of peptides and proteins. The sorbent has 20 pm in diameter particles (pore size 30 nm, specific surface area 5 m2/g) and withstands pressure of eluent up to 135 bar. There is no limitation of pH range, however, low specific area and capacity (1.1 mg tRNA/g) and relatively low limits of working pressure do not allow the use of this sorbent for preparative chromatography. 

Colman RW, Schmaier AH (1997) Contact system a vascular biology modulator with anticoagulant, profibrinolytic, antiadhesive, and proinflammatory attributes. Blood 90 3819-3843... 

Binding affinities of the new flexible synthetic glycocluster toward type-1-piliated E. coli were evaluated by HAI and bladder-binding assay (BBA). The results indicated that, with an inhibition of bacterial bladder-cell binding at 12 nM ( 6000- and 64-fold lower than mannose and 59, respectively), the tetravalent compound 60 is currently one of the most promising antiadhesive drugs under development for the treatment of urinary tract infections. 

S. G. Gouin, A. Wellens, J. Bouckaert, and J. Kovensky, Synthetic multimeric heptyl mannosides as potent antiadhesives of uropathogenic Escherichia coli, ChemMedChem, 4 (2009) 749-755. 

C. D. Heidecke and T. K. Lindhorst, Iterative synthesis of spacered glycodendrons as oligomannoside mimetics and evaluation of their antiadhesive properties, Chem. Eur. J., 13 (2007) 9056-9067. 

DETA/NO is a stable NO-donor with the longest NO generation half-life of approximately 20 h. Thrombelastography performed on rabbit blood showed that DETA NONOate-derived NO significantly decreased coagulation activity and platelet activation [48]. Monitoring by intravital microscopy showed that DETA/NO attenuated the platelets/endothelial cells adhesion response to endotoxins (e.g. lipopolysaccharides) in murine intestinal venules [49]. The main mechanism of the antiadhesive action of DETA/NO on platelets was activation of soluble guanylate cyclase [49]. 

Shmuely, H., Burger, O., Neeman, I., Yahav, J., Samra, Z., Niv, Y., Sharon, N., Weiss, E., Athamna, A., Tabak, M., and Ofek, I. (2004). Susceptibility of Helicobacter pylori isolates to the antiadhesion activity of a high-molecular-weight constituent of cranberry. Diagn. Microbiol. Infect. Dis. 50, 231-235. 

Burstein H, Andette CA, Breurr A, Devane WA, Colodner S, Doyle SA, Mechoulam R. (1992) Synthetic nonpsychotropic cannabinoids with potent antiinflammatory, analgesic, and leukocyte antiadhesion activities. J Med Chem35 3135-3141. 

Daglia, M. Tarsi, R. Papetti, A. Grisoli, R Dacarro, C. Pruzzo, C. Gazzani, G. Antiadhesive Effect of Green and Roasted Coffee on Streptococcus mutans Adhesive Properties on Saliva-Coated Hydroxyapatite Beads, j. Agric. Food Chem. 2002, 50, 1225-1229. 

Green SK, Francia G, Isidore C et al (2004) Antiadhesive antibodies targeting E-cadherin sensitize multicellular tumor spheroids to chemotherapy in vitro. Mol Cancer Ther 3 149-159... 

Dhein S, Schott M, Gottwald E, Muller A, Klaus W The contribution of neutrophils to reperfsuion arrhythmias and a possible role for antiadhesive pharmacological substances. Cardiovasc Res 1995a 30 881-888. 

Cumashi, A., Ushakova, N. A., Preobrazhenskaya, M. E., D Incecco, A., Piccoli, A., Totani, L., Tinari, N., Morozevich, G. E., Berman, A. E., Bilan, M. I., Usov, A. I., Ustyuzhanina, N. E., et al. (2007). A comparative study of the anti-inflammatory, anticoagulant, antiangio-genic, and antiadhesive activities of nine different fucoidans from brown seaweeds. Glycobiology 17, 541-552. 

Certain bioflavonoids may play a preventive role against cardiovascular diseases. Some citrus and other bioflavonoids have been demonstrated to reduce serum cholesterol levels and to affect fatty acid metabolism (70,71,72). The strong antiadhesive action on red cells and platelets of highly methoxylated flavones such as nobiletin, which also demonstrates antithrombogenic activity (73), indicates an important role in blood rheology and tissue perfusion. The antiadhesive action may indicate a preventive role in atherosclerosis since there is evidence that reduced perfusion of the vascular wall may interact with serum lipids to promote atherogenesis (74). 

Bioflavonoids have been discovered to exert an antiadhesive action on blood cells. Erythrocyte adhesion is a general accompaniment of disease and trauma and has rheological implications. Hesperidin or other of the less active fiavonoids administered to a series of patients or added to blood in vitro may show three kinds of activity, inhibit blood cell adhesion in some, no effect in others or accelerate adhesion in still others, i.e., a trimodal action. This characteristic feature of flavonoid action undoubtedly has been interpreted as an inconsistent effect. However, all fiavonoids do not show a trimodal action. Also, there is considerable evidence linking rheological effects of bioflavonoids to their effects on capillary defects and beneficial effects in disease. Thus, the trimodal effects may explain the apparent inconsistent action against the above phenomena. 

Polyironphenylsiloxane varnish is used as a catalyst for the chlorination of aromatic hydrocarbons in the nucleus and as a thermostabiliser for antiadhesion silicone coatings. 

Heat carriers and coolant fluids Antiadhesion compositions Hardening agents... 

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