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Deta nonoate

DETA NONOate ((Z)-l-[N-(2-Aminoethyl)-(V-(2-ammonioethyl) amino]diazen-l-ium-l,2-diolate)... [Pg.241]

DETA/NO is a stable NO-donor with the longest NO generation half-life of approximately 20 h. Thrombelastography performed on rabbit blood showed that DETA NONOate-derived NO significantly decreased coagulation activity and platelet activation [48]. Monitoring by intravital microscopy showed that DETA/NO attenuated the platelets/endothelial cells adhesion response to endotoxins (e.g. lipopolysaccharides) in murine intestinal venules [49]. The main mechanism of the antiadhesive action of DETA/NO on platelets was activation of soluble guanylate cyclase [49]. [Pg.241]

Deta nonoate [2,2 (hydroxynitrosohydrazono)his-ethanamine], a zwitterion nitric oxide donor, potently inhibited forskohn- and angiotensin II-stimulated aldosterone production in human adrenocortical H295R cells in a concentration-depen-dent manner (Kreklau et al. 1999). [Pg.130]

Fig. 3.4 Effect of different concentrations of NO on thymidine uptake in MDA-MB-23f ceils. Cells were plated on 96-well plates and allowed to grow overnight. Cells were treated with H-thymidine for 3 h with various concentrations of DETA-NONOate cells were harvested and H-thymidine incorporation was measured. Data are presented as percentage change compared to control cells. Adapted from Pervin et al. (2008b) with permission from the pubhsher... Fig. 3.4 Effect of different concentrations of NO on thymidine uptake in MDA-MB-23f ceils. Cells were plated on 96-well plates and allowed to grow overnight. Cells were treated with H-thymidine for 3 h with various concentrations of DETA-NONOate cells were harvested and H-thymidine incorporation was measured. Data are presented as percentage change compared to control cells. Adapted from Pervin et al. (2008b) with permission from the pubhsher...
Adams et al. (2001) NONOates Human leukaemia (B-CLL) MTS cell proliferation dependent on half-time of NO release Lowest IC50 274 p,M (DETA-NO) ... [Pg.389]

Postovit et al. (2004) NONOate and GTN Murine melanoma (B16F10) Exposure in vitro to GTN (20 pM) or DETA-NO (1 fM) reversed hypoxia-enhanced metastasis... [Pg.389]

Early studies examined the cytotoxicity of a range of NONOates (MAMA-NO, PAPA-NO and DETA-NO) against acute nonlymphocytic leukaemia cells (Shami et al. 1998) and chronic lymphocytic leukaemia (B-CCL) cells and compared the ICso of each with their NO release kinetics (Adams et al. 2001). The most cytotoxic (ICso 274 xM) was DETA-NO with a release half-time of 20 h whereas MAMA-NO with a release half-time of 1 min was the least toxic (IC50 1.6 mM). A linear relationship was established between IC50 and the log of the release half-time. [Pg.394]

Azizzadeh et al. (2001) NONOates/ cisplatin Laryngeal SCC (CCL23) Cell viability (MTT) LDso reduced 2.7-fold by pre-exposure to DETA-NO (100 (jiM) ... [Pg.406]

Matthews et al. (2001) NONOate or GTN/ doxorubicin (DOX) Human breast cancer (MDA-MB-231) Clonogenic survival GTN or DETA-NO (1 p,M) reverse hypoxia-induced resistance to DOX ... [Pg.408]

See other pages where Deta nonoate is mentioned: [Pg.347]    [Pg.215]    [Pg.372]    [Pg.572]    [Pg.47]    [Pg.51]    [Pg.139]    [Pg.274]    [Pg.274]    [Pg.347]    [Pg.215]    [Pg.372]    [Pg.572]    [Pg.47]    [Pg.51]    [Pg.139]    [Pg.274]    [Pg.274]    [Pg.216]    [Pg.217]    [Pg.219]    [Pg.110]    [Pg.410]   
See also in sourсe #XX -- [ Pg.130 , Pg.372 , Pg.572 ]



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DETA

NONOate

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