Of rabbit blood

To achieve DEP over a large region, a large-area traveling wave DEP was developed. This was conducted on a glass chip consisting of 1000 electrodes. In the DEP separation of rabbit blood cells, it was observed that rabbit erythrocytes traveled faster than leukocytes [266]. 

Brand S, Bon C, Touqui L, and Mounier C (2000) Activation of rabbit blood platelets by anandamide through its cleavage into araehidonie acid. FEBS Lett 471 12-16. 

P-Hemolysis of rabbit blood (68%, 5 days, 3TC) Colonies at 4 days, pigmentation of colonies... 

Hovig, T., 1965, The effect of various enzymes on the ultrastructure, aggregation and clot retraction ability of rabbit blood platelets, Thromb. Diath. Haemorrhag. 13 84-113. 

Pharmacological Action. According to Curci, oxyacanthine in doses of 01 to 0-2 gm. produces in rabbits quick and laboured respiration, muscular tremors, clonic convulsions and cessation of respiration before the heart stops. Raymond-Hamet states that oxyacanthine hydrochloride in a dose of 10 mgm. injected into the femoral artery of a dog produced dilation of the blood vessels in the leg and general hypotension. 

The controlled release from PTA-SA 50 50 of several drugs known to inhibit the formation of new blood vessels in vivo, cortisone and heparin, is shown in Fig. 9 (15). The inhibitors of angiogenesis delivered in vivo using this polyanhydride were shown to prevent new blood vessel growth for over 3 weeks, following the implantation of the VX2 carcinoma into rabbit cornea (15). 

FIGURE 19 Daily rabbit blood plasma levels of levonorgestrel from a crosslinked polymer prepared from a 3,9-bis(ethylidene-2,4,8,10-tetraoxaspiro[5,5Jundecane)/3-methyl-l,5-pentanediol prepolymer crosslinked with 1,2,6-hexane triol. Polymer rods, 2.4 x 20 mm, containing 30 wt% levonorgestrel and 7.1 mol% Mg(OH)2. Devices implanted subcutaneously in rabbits, (o) 1 device/rabbit, ( ) 3 devices/rabbit. (From Ref. 2.)... 

The mature red blood cell cannot synthesize protein. Reticulocytes are active in protein synthesis. Once reticulocytes enter the circulation, they lose their intracellular organelles (ribosomes, mitochondria, etc) within about 24 hours, becoming young red blood cells and concomitandy losing their ability to synthesize protein. Extracts of rabbit reticulocytes (obtained by injecting rabbits with a chemical—phenylhydrazine—that causes a severe hemolytic anemia, so that the red cells are almost completely replaced by reticulocytes) are widely used as an in vitro system for synthesizing proteins. Endogenous mRNAs present in these reticulocytes are destroyed by use of a nuclease, whose activity can be inhibited by addition of Ca +. The system is then pro-... 

In rabbits under light amytal anesthesia, chlordan has no direcr effect on the blood pressure, but produces a type of respiration having many characteristics in common with Cheyne-Stokes type. The generalized tremors, opisthotonus, tonic and clonic convulsions, produced by chlordan were decreased or abolished and respiration restored to normal by suitable injections of the sodium salts of amytal, phenobarbital, and pentothal. The LD60 of chlordan, which was about 20 mg. per kg. on intravenous administration to intact rabbits, was increased to about 60 mg. per kg. through the antidotal action of the barbiturates. An unidentified chlorine-containing degradation product with acidic properties was recovered from the urine of rabbits treated with chlordan. Approximately one third of its chlorine content was set free on hydrolysis at 100° C. with sodium hydroxide in either absolute alcohol or in water. 

Figure 1. Kymographic Tracing Showing Effects of Chlordan on Blood Pressure and Respiration of Rabbit under Light Pentothal Anesthesia and Antagonistic Action of...

The effects of chlordan on the blood pressure and respiration of rabbits under sodium pentothal, in general, were characteristic of those obtained under sodium amytal and sodium phenobarbital, with some variation in intensity and length of duration. 

In vivo Release of Desmopressin and Somatostatin. The in vivo release of Desmopressin and Somatostatin after subcutaneous and intramuscular injections of the peptide in the cubic or the lamellar phase has been studied in the rabbit. Blood was sampled at regular intervals, and systemically absorbed Desmopressin and Somatostatin were determined as the specific immunoreactitvity in plasma of the actual peptide. For details of the analyses with dDAVP, consult ref. 9. For comparison, Desmopressin-like and Somatostatin-like immunoreactitvity (dDAVP-LI and SRIF-LI) in plasma after intravenous bolus injections of the two peptides were determined as well. 

Rojkovicova, T., Lehotay, J., Cizmarik, J. (2003h). Kinetic study of derivatives of phenylcar-hamic acid enantiomers in rabbit blood serum using an online coupled column liquid chromatographic system. Pharmazie 58, 483-486. 

These specific substances or blood group factors are detected by their property of inhibiting agglutinin reactions between human erythrocytes and heterologous human sera. This is the so-called isoagglutinin test which can detect the factors in dilutions of more than 1 part in 10 million. An even more sensitive but less specific test is their power to inhibit hemolysis of sheep s erythrocytes by the serum of rabbits immunized with certain human corpuscles. 

Figure 10 presents the results of assay of VE and ACL in blood plasma of rabbits treated with probucol and two other synthetic antioxidants (S-l, S-2) for 4 weeks. In addition to an improvement in antioxidative blood plasma protection, in the case of compound S-2 a statistically significant (p < 0.01) decrease in vitamin E content was detected, a finding considered physiologically unfavorable. 

DETA/NO is a stable NO-donor with the longest NO generation half-life of approximately 20 h. Thrombelastography performed on rabbit blood showed that DETA NONOate-derived NO significantly decreased coagulation activity and platelet activation [48]. Monitoring by intravital microscopy showed that DETA/NO attenuated the platelets/endothelial cells adhesion response to endotoxins (e.g. lipopolysaccharides) in murine intestinal venules [49]. The main mechanism of the antiadhesive action of DETA/NO on platelets was activation of soluble guanylate cyclase [49]. 

SNVP is a lipophilic N-substituted valeryl analog of SNAP. It caused prolonged nitric oxide mediated vasodilatation in rats [70, 71]. In vivo, SNVP prevented the hyper-aggregability of circulating platelets caused by angioplasty of rabbit carotid arteries. Here, only minor effects on blood pressure were observed, whereas platelet adhesion was strongly inhibited [71]. 

The differences between the enzyme preparations with respect to the requirement of added methylene blue are in good agreement with the finding of varying amounts of MHb in the normal blood of several species (H7) and variable, but species-linked abilities to reduce MHb (K9, Kll, S17). Furthermore, an age variation in MHb reduction of rabbit erythrocytes has been observed (S17). 

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