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Proteins adhesive

Yamada K M and Kennedy D W 1978 Dualistie nature of adhesive protein funetion fibroneetin and its biologieally aetive peptide fragments ean autoinhibit fibroneetin funetion J. Cell Biol. 99 29-36... [Pg.2639]

Rossmann suggested that the canyons form the binding site for the rhi-novirus receptor on the surface of the host cells. The receptor for the major group of rhinoviruses is an adhesion protein known as lCAM-1. Cryoelectron microscopic studies have since shown that ICAM-1 indeed binds at the canyon site. Such electron micrographs of single virus particles have a low resolution and details are not visible. However, it is possible to model components, whose structure is known to high resolution, into the electron microscope pictures and in this way obtain rather detailed information, an approach pioneered in studies of muscle proteins as described in Chapter 14. [Pg.338]

These interactions involve adhesion proteins called selectins, which are found both on the rolling leukocytes and on the endothelial cells of the vascular walls. Selectins have a characteristic domain structure, consisting of an N-terminal extracellular lectin domain, a single epidermal growth factor (EGR) domain, a series of two to nine short consensus repeat (SCR) domains, a single transmembrane segment, and a short cytoplasmic domain. Lectin domains, first characterized in plants, bind carbohydrates... [Pg.283]

A diagram showing the interactions of selectins with their receptors. The selectin family of adhesion proteins. [Pg.283]

Cadherins (Calcium-dependent adhesion proteins) are transmembrane proteins, which consist of an extracellular domain composed of cadherin-repeats, a transmembrane domain, and a cytoplasmic domain that interacts with catenins and/or other cytoplasmic proteins. [Pg.306]

Among the substrates of Src are other nonreceptor PTKs (e.g., Fak, Syk, and Tec kinases), RTKs (e.g. EGF and PDGF receptors), phospholipase Cy, PI3-kinase, phosphatases (e.g., SHP-2 and PP2A), and adaptor (e.g., She and Cbl) as well as focal adhesion proteins (e.g., paxillin, pl30Cas andtensin). Src-mediated phosphorylation either modulates enzymatic activity of... [Pg.1259]

Adhesion of neutrophils to endothelial cells employs specific adhesive proteins (integrins) located on their surface and also specific receptor proteins in the endothelial cells. (See also the discussion of selectins in Chapter 47.)... [Pg.620]

Flavonoids inhibit cytiokine-indnced endothelial cell adhesion protein gene expression American Journal Patholology 147, 278-92. [Pg.16]

Lutz, K.L. Szabo,L. A. Thompson, D.L. Siahaan, T. J., Antibody recognition of peptide sequence from the cell-cell adhesion proteins N- and E-cadherins, Peptide Res. 9, 233-239 (1996). [Pg.255]

Figure 4c shows that the amount of adsorbed proteins is rapidly saturated within several minutes of exposing serum-containing medium to a surface. Albumin, the most abundant serum protein, was expected to preferentially adsorb onto the surfaces during early time points. Then, adsorbed albumin was expected to be displaced by cell adhesion proteins. To investigate the effect of preadsorbed albumin displacement on cell adhesion, SAMs were first exposed to albumin then, HUVECs suspended in a serum-supplemented medium were added [21, 42]. Very few cells adhered to hydrophobic SAMs that had been pretreated with albumin, due to the large interfacial tension between water and the hydrophobic surfactant-like surface. Albumin was infrequently displaced by the cell adhesive proteins Fn and Vn. One the other hand, HUVECs adhered well to hydrophilic SAM surfaces that had been preadsorbed with albumin. In that case, the preadsorbed albumin was readily displaced by cell adhesive proteins. [Pg.177]

Barrias CC, Martins MCL, Almeida-Porada G, Barbosa MA, Granja PL (2009) The correlation between the adsorption of adhesive proteins and cell behaviour on hydroxyl-methyl mixed self-assembled monolayers. Biomaterials 30 307-316... [Pg.197]

ASBA has been used to identify parasite adhesive proteins (Gowda et al., 2007), for active site-directed labeling of glucosidase I (Romaniouk et al., 2004), and to study interactions with the proteasome (Qureshi et al., 2003). [Pg.333]

Gowda, A.S.P., Madhunapantula, S.V., Achur, R.N., Valiyaveettil, M., Bhavanandan, V.P., and Gowda, D. C. (2007) Structural basis for the adherence of plasmodium falciparum-infected erythrocytes to chon-droitin 4-sulfate and design of novel photoactivable reagents for the identification of parasite adhesive proteins./. Biol. Chem. 282, 916-928. [Pg.1068]

More recently, increasing research attention has focused upon the use of mucoadhe-sive delivery systems in which the biopharmaceutical is formulated with/encapsulated in molecules that interact with the intestinal mucosa membranes. The strategy is obviously to retain the drug at the absorbing surface for a prolonged period. Non-specific (charge-based) interactions can be achieved by the use of polyacrylic acid, whereas more biospecihc interactions are achieved by using selected lectins or bacterial adhesion proteins. Despite intensive efforts, however, the successful delivery of biopharmaceuticals via the oral route remains some way off. [Pg.71]

Cell-adhesion molecules [138] are multifunctional molecules which are involved in a number of cell-regulatory processes, including growth, differentiation, proliferation, and programmed cell-death. Adhesion proteins share a similar... [Pg.216]

Semicarbazide Sensitive Amine Oxidase and Vascular Adhesion Protein-1 One Protein Being Validated as a Therapeutic Target for Inflammatory Diseases... [Pg.229]

AOC-3 Amine oxidase, copper-containing 3 (vascular adhesion protein 1) HPAO, 17q21 SSAO, VAP1, VAP-1, 38,256,727 -38,263, 667 6941 4 4026 763... [Pg.231]

Semicarbazide Sensitive Amine Oxidase and Vascular Adhesion Protein-1... [Pg.231]


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See also in sourсe #XX -- [ Pg.346 ]

See also in sourсe #XX -- [ Pg.161 , Pg.173 , Pg.346 ]




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Protein adhesion

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