Semicarbazide-sensitive amine oxidases

Semicarbazide Sensitive Amine Oxidase and Vascular Adhesion Protein-1 One Protein Being Validated as a Therapeutic Target for Inflammatory Diseases... 

Semicarbazide Sensitive Amine Oxidase and Vascular Adhesion Protein-1... 

Holt A, Wieland B, Baker GB. 2004. Allosteric modulation of semicarbazide-sensitive amine oxidase activities in vitro by imidazoline receptor ligands. Br J Pharmacol 143 495. 

Semicarbazide-sensitive amine oxidase (SSAO) (rat) SSAO can generate vasoactive H2O2. HA (1 mM) inhibits staining of SSAO in rat aorta, and is thought to antagonize H202-induced vasoconstriction 26, 48... 

Amine oxidases catalyze the oxidative deamination of both xenobiotic and biogenic amines, and thus have many critical biological functions. Two distinct classes differ in the nature of their prosthetic groups [1]. The flavin-(FAD flavin adenine dinucleotide)-dependent amine oxidases include monoamine oxidases (MAO A and B) and polyamine oxidases. Amine oxidases not containing FAD, the so-called semicarbazide-sensitive amine oxidases (SSAO), include both plasma amine oxidases and tissue amine oxidases. These contain quinonoid structures as redox cofactors that are derived from posttranslationally modified tyrosine or tryptophan side chains, topaoquinone frequently playing this role [2]. 

P. Matyus, B. Dajka-Halasz, A. Foldi, N. Haider, D. Barlocco, K. Magyar, Semicarbazide-sensitive amine oxidases Current status and perspectives, Curr. Med. Chem. 11 (2004) 1285-1298. 

G.A. Lyles, C.M.S. Marshall, I.A. McDonald, P. Bey, M.G. Palfreyman, Inhibition of rat aorta semicarbazide-sensitive amine oxidase by 2-phenyl-3-haloallylamines and related compounds, Biochem. Pharmacol 36 (1987) 2847-2853. 

Fig. 10.1 Cellular formation and metabolism of methylglyoxal (MG). AGEs advanced glycoxida-tion endproducts DHAP dihydroxyacetone phosphate G3P glyceraldehyde 3-phosphate F-6P fructose 6-phosphate F-1,6P2 fmctose 1,6-bisphosphate Gly-I II glyoxalase I II SSAO semicarbazide-sensitive amine oxidase AMO amine oxidase.

Ekblom, J. 1998. Potential therapeutic value of drugs inhibiting semicarbazide-sensitive amine oxidase vascular cytoprotection in diabetes mellitus. Pharmacol Res 37 87-92. 

Holt, A., Alton, G., Seaman, C. H., Loppnow, G. R., Szpacenko, A., Svendsen, 1., and Palcic, M. M., 1998, Identification of die quinone cofactor in mammalian semicarbazide-sensitive amine oxidase, Biochemistry 37 4946n4957. 

Recently, the cofactor peptides have also been isolated from semicarbazide-sensitive amine oxidases purified from bovine and porcine aortas [52], sequenced and confirmed to contain the topa quinone. The same topa quinone consensus sequence was also found in the primary structures of amine oxidases from human kidney [53], human retina [54] and rat colon [55], so called amiloride-binding proteins , and amine oxidase from human placenta [56] that shows 81% identity with bovine plasma amine oxidase [57], bovine lung amine oxidase [58], and amine oxidases from pea and lentil seedlings [59,60], chick pea seedlings [61], and Arabidopsis thaliana [62] obtained by the molecular cloning of respective DNAs. 

Porcine aorta (semicarbazide sensitive amine oxidase) NxDYY [52]... 

---