Abdominal infections sepsis

It is used for bacterial infections caused by microorganisms that are sensitive to the drug. These may be abdominal and gynecological infections, sepsis, meningitis, endocarditis, infections of the urinary and respiratory tracts, bones, joints, skin, and soft tissnes. It is widely nsed for pneumonia as well as bacterial meningitis in children, and for post-operational infections complications. Synonyms of this drug are ceftin, zinacef, curoxim, kefox, and many others. 

Although the need for surgical intervention distinguishes most intra-abdominal infections from non-surgical infections, antimicrobial agents also play a major role in controlling sepsis and limiting the extent of dissemination of the infection in abdominal sepsis. In clinically stable patients without... 

The most common adverse reaction to etanercept is mild to moderate erythema, pain, or pruritus at the injection site (37%). Headaches and abdominal pain can also occur. New positive autoantibodies, such as antinuclear antibodies (ANA), anti-dsDNA antibodies, and anticardiolipin antibodies, can develop in patients treated with etanercept. Although there is so far no association between this and the development of autoimmune diseases or malignancies, long-term studies have yet to be done. Rare cases of pancytopenia may be associated with this drug. Although clinical trials showed no increased risk of infection with etanercept treatment, postmarketing reports of serious infections, sepsis, and associated fatalities exist. 

Jiang, J., Xie, G., Liu, D., Zhu, P., Wang, Z., He, Y., Zhou, J., Xu, H. Effect of bactericidal /permeability-increasing protein on sepsis induced by intra-abdominal infection in rats. Chin J Traumatol 2 (1999a) 84-86. 

Treatment of sepsis to which anaerobic organisms, e.g. Bacteroides spp. and anaerobic cocci, are contributing, notably postsurgical infection, intra-abdominal infection and septicaemia, but also woimd and pelvic infection, osteomyelitis and abscesses of brain or lung... 

Katta Bolic was in a severe stage of negative nitrogen balance on admission, which was caused by both her malnourished state and her intra-abdominal infection complicated by sepsis. The physiologic response to her advanced catabolic status includes a degradation of muscle protein with the release of amino acids into the blood. This release is coupled with an increased uptake of amino acids for "acute phase" protein synthesis by the liver (systemic response) and other cells involved in the immune response to general and severe infection. 

Katta Bolic s severe negative nitrogen balance was caused by both her malnourished state and her intra-abdominal infection complicated by sepsis. The systemic and diverse responses the body makes to insults such as an acute febrile illness are termed the "acute phase response." An early event in this response is the stimulation of phagocytic activity (see Fig. 42.17). Stimulated macrophages release cytokines, which are regulatory proteins that stimulate the release of cortisol, insulin, and growth hormone. Cytokines also directly mediate the acute phase response of the liver and skeletal muscle to sepsis. 

Mustard RA, Bohnen JMA, Rosati C, Schouten D. Pneumonia com- Solomkin JS, Mazuski JE, Baron EJ, et al. Guidelines for the selection plicating abdominal sepsis. Arch Surg 1991 126 170-175. of anti-infective agents for complicated intraabdominal infec-... 

Signs and Symptoms Abdominal pain, cramps, diarrhea, fever, vomiting, tenesmus, and blood, pus, or mucus in stools. Infections also cause mucosal ulceration, rectal bleeding, drastic dehydration. Serious less frequent complications include sepsis, seizures, convulsions, rectal prolapse, toxic megacolon, intestinal perforation, renal failure, and hemolytic uremic syndrome. 

Septic shock 1) shock associated with sepsis, usually associated with abdominal and pelvic infection complicating trauma or operations 2) shock associated with septicemia caused by Gram-negative bacteria. 

It is used for peritonitis, sepsis, meningitis, cholangitis, empyema of the gaU bladder, pneumonia, lung abscesses, pyelonephritis, infections of the bones, joints, skin, soft tissues, abdominal and gynecological infections, and for infected wounds and bums. The main synonym of this drug is rocefm. 

Adverse reactions occurring in at least 3% of patients include the following abdominal pain, atrial fibrillation, back pain, bradycardia, cardiac arrest, chest pain, diarrhea, dyspnea, fever, headache, hypotension, infection. Ml, nausea, pain, pneumonia, sepsis, urinary tract infection, ventricular tachycardia, vomiting. 

The child s subsequent course was one of gradual hepatic deterioration.At age 3 years, he was noted to have ascites (intra-abdominal fluid accumulation). This progressed slowly until the age of 6 years, when severe ascites and peripheral edema necessitated the initiation of spironolactone (a potassium-sparing diuretic). Several admissions to the hospital were required over the next 6 years for ascites with scrotal edema. Serum albumin values were persistently low, less than 2.0 g/dL. During this time, the patient also had two episodes of primary peritonitis (intraperitoneal infection) and one episode of a-streptococcal sepsis. 

Clinical Applications. Lipophilic Tc-exametazime has been shown to label leukocytes without affecting cell viability (Mortelmans et al. 1989 Peters et al. 1986 Roddie et al. 1988). HMPAO-labeled leukocytes have been used to locate site(s) of focal infection (e.g., abdominal abscess, abdominal sepsis) (Kelbaek et al. 1985) it is also indicated in conditions of fever of unknown origin, and in conditions not associated with infection such as inflammatory bowel disease (Arndt et al. 1993 Lantto et al. 1991). Labeled leukocytes have offered superior information when compared with bone scanning for the detection of osteomyelitis in children (Lantto et al. 1992). In a retrospective study in 116 patients with infection suspected to involve orthopedic implants, osteomyelitis, and septic arthritis, HMPAO-labeled leukocytes have been an effective tool in the diagnosis of chronic osteomyelitis and joint infection involving implants (sensitivity > 97%, specificity > 89%) (Devillers et al. 1995). 

Briefly, Tinospora cordifolia reduced mortality associated with intra-abdominal sepsis following caecal ligation. Thus, as compared to a mortality of 66 100% on the fifth day after surgery in untreated rats, 15 days of pretreatment with Tinospora cordifolia alone reduced mortality to 33% and further to 16.6% when combined with metronidazole and gentamicin [19]. This effect was reported to be associated with improved macrophage function. Furthermore, the aqueous extract of Tinospora cordifolia was found to be devoid of in vitro antimicrobial activity against Bacillus subtilis, Bacillus cereus Staphylococcus aureus Pseudomonas aeruginosa and Escherichia coli. Sera obtained from rats (n = 10 each) orally treated with the aqueous extract of Tinospora cordifolia in doses of 100 and 200 mg/kg were also found to have no antibacterial activity [19]. These data further indicated that Tinospora cordifolia was effective in infections due to its immunostimulant effects. 

Contraindications toliver transplantation include uncontrolled active extrahepatic sepsis, advanced cardiorespiratory disease, extrahepatic malignancy, active substance abuse, medical non-compliance, and significant irreversible brain injury. A history of previous abdominal surgery, the presence of portal vein thrombosis, or congenital anomalies of the inferior vena cava are no longer considered a barrier to transplantation. Co-infection with human immunodeficiency virus is also no longer considered... 

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