Rectal bleeding

Notify the primary health care provider if constipation is not relieved or if rectal bleeding or other symptoms occur. 

Corticosteroid intrarectal foam, hydrocortisone acetate intrarectal foam Cortifoam Adjunctive therapy in treatment of ulcerative proctitis of the distal portion of the rectum Local pain or burning, rectal bleeding, apparent exacerbations or sensitivity reactions 1 applicatorful once or twice daily for 2 wk and every second day thereafter... 

Ulcerative colitis Diarrhea (bloody, watery, or mucopurulent), rectal bleeding, abdominal pain/cramping, weight loss and malnutrition, tenesmus, constipation (with proctitis)... 

Ischemic colitis has been observed in some patients taking tegaserod. The drug should be discontinued promptly if rectal bleeding, bloody diarrhea, or worsening abdominal pain occurs. 

Signs and Symptoms Abdominal pain, cramps, diarrhea, fever, vomiting, tenesmus, and blood, pus, or mucus in stools. Infections also cause mucosal ulceration, rectal bleeding, drastic dehydration. Serious less frequent complications include sepsis, seizures, convulsions, rectal prolapse, toxic megacolon, intestinal perforation, renal failure, and hemolytic uremic syndrome. 

Indomethacin suppositories History of proctitis or recent rectal bleeding. 

Ischemic colitis Ischemic colitis and other forms of intestinal ischemia have been reported in patients receiving tegaserod during marketed use of the drug. Discontinue tegaserod immediately in patients who develop symptoms of ischemic colitis, such as rectal bleeding, bloody diarrhea, or new or worsening abdominal pain. 

Contraindications Abdominal pain, appendicitis, intestinal obstruction, nausea, undiagnosed rectal bleeding, vomiting... 

Notify the physician if unrelieved constipation, dizziness, muscle cramps or pain, rectal bleeding, or weakness occurs... 

Notify clinician if unrelieved constipation, rectal bleeding, muscle cramps, weakness, or dizziness occurs... 

Bleeding from gums, puncture sites, or wounds hematuria fever G1 and rectal bleeding... 

Inflammatory Bowel disease-. Decrease in rectal bleeding or diarrhea in conjunction wit h mucosal healing... 

Ischemic colitis, mesenteric ischemia, gangrenous bowel, rectal bleeding, syncope, hypotension, hypovolemia, electrolyte disorders, suspected sphincter of Oddi spasm, bile duct stone, cholecystitis with elevated transaminases, and hypersensitivity reaction including rash, urticaria, pruritus, and serious allergic type 1 reactions have been reported,... 

Adverse effects in patients include nausea, vomiting, anorexia, diarrhea, abdominal pain, pharyngitis, stomatitis, enterocolitis, rectal bleeding, blood anomalies, paresthesias, peripheral neuritis, mental depression, loss of tendon reflexes, headache, and convulsions.2... 

If Mrs P was over 45 years old and had a rapid onset of symptoms then she would be referred for further investigation. Symptoms likely to require further investigations include rectal bleeding, anaemia, weight loss, a family history of cancer or imflammatory bowel disease, or signs of an infection. 

Flutamide (EULEXIN, EUFLEX) Nonsteroidal LH increased T increased Monotherapy Combination therapy Potency spared Breast tenderness, nausea and vomiting, diarrhea, rectal bleeding, hot flashes, cystitis, increased appetite, sleep disturbances, hepatotoxicity, anemias, hemolysis, headache, dizziness, malaise, blurred vision, anxiety, depression, decreased libido, hypertension, complications in patients with cardiovascular disease... 

Q12 Irritation and damage to other structures in the abdomen may occur if the diverticulitis is not treated. Abdominal muscles may go into painful spasm and a minority of patients might have rectal bleeding. A major problem could be development of an intestinal obstruction or an abscess in the wall of the intestine. The abscess may eventually cause perforation of the intestinal wall leakage of infected material into the peritoneal cavity and then infection of the peritoneal membranes (peritonitis) may occur. Peritonitis is a very serious condition. 

Gastrointestinal Incontinence of feces, intestinal malabsorption, fat-soluble vitamins, rectal discharge, rectal bleeding... 

Figure 3.6. Formation of a diverticulum, (A) A cross-sectiun of the wail of the colon reveals the mucasal layer (top surface of diagram), pari of the belt of muscle that encircles the gut, and an artery passing through a naturally occurring gap in the muscle. (B) As middle age approaches, weak spots may develop in places where there exist gaps between muscles-(C) Diverticuli develop. The artery follows the path of the outpouching, and it is this part of the artery that may rupture and bleed and produce rectal bleeding in persons with diverticular disease. (Redrawn with permission from Meyers ef ai, 1976.)...

In a placebo-controlled study in 48 patients with active rheumatoid arthritis, CD4 blockade produced clinical benefit (5). Adverse events were reported in 97% of the patients, compared with 73% of those given placebo. In both groups most of the events were mild to moderate. Serious adverse events were reported in five patients who received anti-CD4 syncope/vasovagal attacks (n = 3), back pain (n = 1), abdominal pain/rectal bleeding (n = 1). Skin rashes occurred in 62% of the patients who received the antibody. In five cases a skin biopsy was performed, and showed a cellular infiltration centered on the blood vessels, suggesting a drug-induced vasculitis. 

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