Brain injuries

Neurological diseases Huntington s disease (A), amylotrophic lateral sclerosis (A,I), Parkinson s disease (A), traumatic brain injury (A,I), glaucoma (A)... [Pg.332]

ChEI treatments have been expanded also to include other dementias and CNS disorders, e.g. delirium, traumatic brain injuries and memory impairments, as well as myasthenia gravis, glaucoma and parasite infections. [Pg.360]

Traumatic brain injury is the most common cause of death in subjects under the age of 40, and an important risk factor for AD. Loss of hippocampal cells and depletion of ACh and of muscarinic receptors can be attenuated in injured experimental animals, improve blood perfusion in ischemic areas and increase cholinergic transmission in cortex and hippocampus the same mechanism invoked for treatment of VD. [Pg.360]

Epilepsy may be defined as a permanent, recurrent seizure disorder. Examples of the known causes of epilepsy include brain injury at birth, head injuries, and inborn errors of metabolism, hi some patients, the cause of epilepsy is never determined. [Pg.254]

Gonzalez RG, Cheng LL, Westmoreland SV, Sakaie KE, Becerra LR, Lee PL, Masliah E, Lackner AA (2000) Early brain injury in the SlV-macaque model of AIDS. Aids 14(18) 2841-2849 Gonzalez-Scarano F, Marfin-Garcia J (2005) The neuropathogenesis of AIDS. Nat Rev Immunol 5(1) 69-81... [Pg.25]

Miller RJ, Banisadr G, Bhattacharyya BJ (2008) CXCR4 signaUng in the regulation of stem ceU migration and development. J Neuroimmunol 198 31-38 Minami M, Satoh M (2003) Chemokines and their receptors in the brain pathophysiological roles in ischemic brain injury. Life Sci 74 321-327... [Pg.246]

Cotter R, Williams C, Ryan L et al (2002) FractaUdne (CX3CL1) and brain inflammation impU-cations for HIV-l-associated dementia. J Neurovirol 8 585-598 Cunha-Reis D, Ribeiro JA, Sebastiao AM (2008) Al and A2A receptor activation by endogenous adenosine is required for VIP enhancement of K+-evoked [3H]-GABA release from rat hippocampal nerve terminals. Neurosci Lett 430 207-212 Davalos D, Grutzendler J, Yang G et al (2005) ATP mediates rapid microglial response to local brain injury in vivo. Nat Neurosci 8 752-758... [Pg.313]

Ma J, Endres M, Moskowitz MA. Synergistic effects of caspase inhibitors and mk-801 in brain injury after transient focal cerebral ischaemia in mice. Br J Pharmacol 1998 124 756-762. [Pg.118]

Ma J, Qiu J, Hirt L, Dalkara T, Moskowitz MA. Synergistic protective effect of caspase inhibitors and bfgf against brain injury induced by transient focal ischaemia. Br J Pharmacol 2001 133 345-350. [Pg.118]

Asahi M, Asahi K, Wang X, Lo EH. Reduction of tissue plasminogen activator-induced hemorrhage and brain injury by free radical spin trapping after embolic focal cerebral ischemia in rats. J Cereb Blood Flow Metab 2000 20 452 57. [Pg.118]

A variety of brain injuries may be impacted by fever, including ischemic... [Pg.168]

Fan JY. Effect of backrest position on intracranial pressure and cerebral perfusion pressure in individuals with brain injury a systematic review. J Neurosci Nurs 2004 36(5) 278-288. [Pg.189]

Meixensberger J, Baunach S, Amschler J, Dings J, Roosen K. Influence of body position on tissue-po2> cerebral perfusion pressure and intracranial pressure in patients with acute brain injury. Neurol Res 1997 19(3) 249-253. [Pg.189]

Stocchetti N, Protti A, Lattuada M, Magnoni S, Longhi L, Ghisoni L, Egidi M, Zanier ER. Impact of pyrexia on neurochemistry and cerebral oxygenation after acute brain injury. J Neurol Neurosurg Psych 2005 76(8) 1135-1139. [Pg.190]

Tokutomi T, Mayagi T, Morimoto K, Kanikaya T, Shigemori M. Effect of h3fpothermia on serum electrolyte, inflammation, coagulation, and nutritional parameters in patients with severe traumatic brain injury. Neurocrit Care 2004 1(2) 171-182. [Pg.191]

Thomas SH, Orf J, Wedel SK, Conn AK. Hyperventilation in traumatic brain injury patients inconsistency between consensus guidelines and clinical practice. J Trauma 2002(l) 52 47-52. [Pg.192]

Chan K-H, Miller JD, Dearden NM, Andrews PJ, Midgley S. The effect of changes in cerebral perfusion pressure upon middle cerebral artery blood flow velocity and jugular bulb venous oxygen saturation after severe brain injury. J Neurosurg 1992 77(1) 55-61. [Pg.195]

HU-210 is (8.1) among the most potent cannabinoids known. Its enantiomer HU-211 (8.2) does not bind to the cannabinoid receptor and lacks psychotropic side effects (as long as optical purity is guaranteed). In animal models it shows analgesic and antiemetic activity. It also shows neuroprotec-tive effects after brain injury and was tested in humans as anti-traiuna agent, where it did not meet the expectations in a clinical phase III trial. [Pg.35]

In a percussive brain injury model in cats, N-acetylcysteine (NAG) preserved normal hyperventilation when administered either prior to or 30 min post-insult (Ellis etal., 1991), NAG was also found to be active in a model of acute immunological alveolitis in the rat in... [Pg.268]

Ellis, E.F., Dodson, L.Y. and Police, R.J. (1991). Restoration of cerebrovascular responsiveness to hyperventilation by the oxygen scavenger N-acetylcysteine following experimental brain injury. J. Neurosurg. 75, 774-779. [Pg.274]

Hall, E.D., Braughler, J.M., Yonkers, P.A., Smith, S.L., Linseman, K.L., Means, E.D., Scherch, H.M., Von Voigt-lander, P.F., Lahti R.A. and Jacobsen, E.J. (1991b). U-78517F a potent inhibitor of lipid peroxidation with activity in experimental brain injury and ischemia. J. Pharmacol. Exp. Ther. 258, 688-694. [Pg.275]

Liu, T.H., Beckman, J.S., Freeman, B.A., Hogan, E.L. and Hsu, C.Y. (1989). Polyethylene glycol-conjugated superoxide dismutase and catalase reduce ischemic brain injury. Am. J. Physiol. 256, H589-593. [Pg.275]

Tanno, H., Nockels, R.P., Pitts, L.H. and Noble, L.J. (1992). Breakdown of the blood brain barrier after fluid percussion brain injury in the rat. 2. Effect of hypoxia on permeability to plasma proteins. J. Neurotrauma, 9, 335-347. [Pg.276]

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