Walker tumor

Colquhoun and Schumacher [98] have shown that y-linolcnic acid and eicosapentaenoic acid, which inhibit Walker tumor growth in vivo, decreased proliferation and apoptotic index in these cells. Development of apoptosis was characterized by the enhancement of the formation of reactive oxygen species and products of lipid peroxidation and was accompanied by a decrease in the activities of mitochondrial complexes I, III, and IV, and the release of cytochrome c and caspase 3-like activation of DNA fragmentation. Earlier, a similar apoptotic mechanism of antitumor activity has been shown for the flavonoid quercetin [99], Kamp et al. [100] suggested that the asbestos-induced apoptosis in alveolar epithelial cells was mediated by iron-derived oxygen species, although authors did not hypothesize about the nature of these species (hydroxyl radicals, hydrogen peroxide, or iron complexes ). 

Liposome-entrapped thalicarpine effective against Walker tumor cells in vitro, though free drug ineffective (by "mTc labeling) 485... 

Jacob, S. T., and H. Busch. 1967. Template activity of nuclear RNA fraction of the Walker tumor. Biochim. Biophys. Acta, 138 249-257. 

Grossfeld, H. Production of hyaluronic acid by fibroblasts growing from exptants of Walker Tumor 256 production of hyaluronidase by... 

Busch and his associates [18-21] attempted to isolate nucleoli from either Walker tumors or liver treated with thioacetamide. They identified the nucleoli with the aid of azure and claim to have obtained, after sonication of the nuclei followed by differential centrifugation, a nucleolar preparation 90-95% free of contamination. The preparation is rich in DNA, relatively poor in RNA but because the yield in nucleoli is low, their nucleolar preparation can hardly be considered representative of the original nuclear preparation. 

Vibrio cholerae Walker tumor cells No change in tumor distribution Weiss et al., 1974... 

Weiss, L., Fisher, B., and Fisher, E. R., 1974, Effect of neuraminidase on the distribution of intravenously injected walker tumor cells in rats. Cancer 34 680-683. 

Wagner E, Kircheis R, Walker GF (2004) Targeted nucleic acid delivery into tumors new avenues for cancer therapy. Biomed Pharmacother 58 152-161... 

The first data on the effects of tamoxifen on uterine leiomyomas were obtained in a rat model. They showed that tamoxifen increased tumor latency and decreased tumor size (Howe et al. 1995). These findings were confirmed more recently by Walker et al. (2000). In the same period, moreover, several case reports were published showing an increase in uterine leiomyoma dimensions following tamoxifen administration (Dilts et al. 1992 Leo et al. 1994 Ugwumadu et al. 1994). 

Hodgson, D.M., Knott, B., and Walker, F.R., Neonatal endotoxin exposure influences HPA responsivity and impairs tumor immunity in Fischer 344 rats in adulthood, Pediatr. Res., 50, 750, 2001. 

Gardner et al.75 (U.S.A.) injected ascetic Walker sarcoma cells into male albino Wistar rats and thus induced tumors in their liver. These tumors were than subjected to ECT by using an implanted... 

Rat mammary tumors Lewis lung cancers Mouse mammary tumors Choriocarcinoma cells Anaplastic sarcomas Walker carcinoma cells Rat prostatic carcinomas Rat embryo fibroblasts Different malignant cells... 

Murphy M, Ahn J, Walker KK (1999) Transcriptional repression by wild-type p53 utilizes histone deacetylases, mediated by interaction with mSin3a. Genes Dev 13 2490-2501 Nakajima H, Kim YB, Terano H, Yoshida M, Horinouchi S (1998) FR901228, a potent antitumor antibiotic, is a novel histone deacetylase inhibitor. Exp Cell Res 241(1) 126-133 Nebbioso A, Clarke N, Voltz E, Germain E, Ambrosino C, Bontempo P, Alvarez R, Schiavone EM, Eerrara F, Bresciani F, Weisz A, de Lera AR, Gronemeyer H, Altucci L (2005) Tumor-selective action of HDAC inhibitors involves TRAIL induction in acute myeloid leukemia cells. Nature Med 11 77-84... 

Miles WO, Dyson NJ, Walker JA (2011) Modeling tumor invasion and metastasis in Drosophila. Dis Model Mech 4 753-761... 

Cancer cachexia and tumor growth reduction in Walker 256 tumor-bearing rats supplemented with N-3 polyunsaturated fatty acids for one generation. CN 151 Nutr Cancer 2003 46(1) 52-58. 

B16 melanoma, Walker sarcoma, and M5076 forming liver metastasis have been used in the preclinical evaluation of HPMA copolymer-adriamydn conjugates [36]. Other tumors useful for secondary screening are MS-2 sarcoma, NMU-1 murine lung adenocarcinoma, and murine adenocarcinoma Colon 26. These have been used by Zunino et al. [147] to determine the activity of poly (carboxylic acid) immobilized anthracyclines. Mice inoculated intramuscularly with Lewis lung carcinoma have been used by Pratesi et al. [215] to assess the effect of a poly-L-aspartic acid/doxorubicin conjugate. 

Bhisutthibhan, J., Pan, X.-O., Hossler, P.A., Walker, D.J., Yowell, C.A., Carlton, J., Dame, J.B., and Meshnick, S.R. The plasmodium falciparum translationally controlled tumor protein homolog and its reaction with the antimalarial drug artemisinin,. Biol. Chem., 273,16192,1998. 

Fig. 15. The antiblastic effect of 1-ethoxysilatrane a) tumorous tissue of Walker carcinoma (control) b) lymphocytes,fibroblasts and collagen blocks c) larger collagen blocks d) connective tissue capsula surrounding tumor cells...

Knight D, Zheng X, Rocchini C, Jacobson M, Bai T, Walker B (1997) Adenosine A3 receptor stimulation inhibits migration of human eosinophils. J Leukoc Biol 62(4) 465-468 Kreckler LM, Wan TC, Ge Z-D, Auchampach JA (2006) Adenosine inhibits tumor necrosis factor-a release from mouse peritoneal macrophages via A2a and A2B but not the A3 adenosine receptor. J Pharmacol Exp Ther 317(1) 172—180... 

In a similar study by Yang and Huang (1996), melanoma tumors in mice were in vivo transfected by the direct intratumoral administration of naked pDNA, resulting in reporter gene expression for up to ten days. In another study, Walker 256 carcinoma tumors in rats were found to express CAT after intratumoral injection of naked pDNA encoding CAT (Nomura et al., 1997). More recently electroporation has been used to deliver naked pDNA to tumors (described further in the following section). 

Kursa M, Walker GF, Roessler V et al (2003) Novel shielded transferrin-polyethylene glycol-polyethylenimine/DNA complexes for systemic tumor-targeted gene transfer. Bioconjug Chem 14 222-231... 

Kursa, M., Walker, G. F., Roessler, V., et al. Novel shielded transferrin—polyethylene glycol—polyethylenimine/DNAcomplexes for systemic tumor-targeted gene transfer. Bioconjug. Chem. 14(1) 222—231. 2003. 

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