Walker sarcoma

Gardner et al.75 (U.S.A.) injected ascetic Walker sarcoma cells into male albino Wistar rats and thus induced tumors in their liver. These tumors were than subjected to ECT by using an implanted... 

B16 melanoma, Walker sarcoma, and M5076 forming liver metastasis have been used in the preclinical evaluation of HPMA copolymer-adriamydn conjugates [36]. Other tumors useful for secondary screening are MS-2 sarcoma, NMU-1 murine lung adenocarcinoma, and murine adenocarcinoma Colon 26. These have been used by Zunino et al. [147] to determine the activity of poly (carboxylic acid) immobilized anthracyclines. Mice inoculated intramuscularly with Lewis lung carcinoma have been used by Pratesi et al. [215] to assess the effect of a poly-L-aspartic acid/doxorubicin conjugate. 

Conjugates showed concentration dependent toxicity against Walker sarcoma (LLC-WRC 256)... 

Conjugates showed ability 38 to inhibit the development of Walker sarcoma (W256) and showed ability to cause regression of established Walker sarcoma... 

It inhibits the growth of tumours by as much as 59-79% for Walker sarcoma,... 

X Dose, mg/kg per day] Inhibition % Jensen Walker sarcoma carcinosarcoma Pliss lympho- sarcoma Carcinoma NK Sarcoma AK Sarcoma 180... 

Camptothecine Antitumor properties, L1210 Walker sarcoma — 286... 

Rat mammary tumors Lewis lung cancers Mouse mammary tumors Choriocarcinoma cells Anaplastic sarcomas Walker carcinoma cells Rat prostatic carcinomas Rat embryo fibroblasts Different malignant cells... 

Copovithane [1,3 bis (methylaminocarboxy)-2 methylene propane carbamate and JV-vinylpyrrolidone copolymer) (Mw = 5 800) Active against sarcoma 180, P388 leukemia, and carcinoma F077I in mice, and Walker 1098 in rats. Inactive in vitro, and is suspected to act through stimulation of host immune system 67... 

Effective on Walker carcinosarcoma, Yoshida sarcoma, and Jensen sarcoma in vivo some action on lymphoma NK/Ly, no effect in sarcoma 37, reduction of survival time for Guer sarcoma some weight loss doses to 150 mg/kg not lethal 512... 

Suppressed growth of Ehrlich ascites tumor, Walker carcinosarcoma, sarcoma 37, Lewis carcinoma, sarcoma 180 in rats intermittent dosage (Walker 517... 

Harringtonine appears to be the most effective agent and recent studies in the People s Republic of China have shown that it is effective against L615 leukemia, L7212 leukemia, sarcoma 180, and Walker carcinosarcoma 256 (188). Harringtonine also appeared to be effective in the treatment of acute and chronic myelocytic leukemia in humans (189). 

Unmodified l-ASP wtt found to have antitumor activity against more than 50 mouse neoplums, rat Muiphy-Sturm, canine lymphosarcomas, rat fibrosarcoma, Walker carcinosarcoma, and Jensen sarcoma [60-62]. 

Walker 256 carcino-sarcoma (advanced) Fisher 344 rats 100 % cures T. I. > 50 c)... 

Walker, N.I., Horn, M.J., Strong, R.W., Lynch, S.V., Cohen, J., Ong, T.H., Harris, O.D. Undifferentiated (embryonal) sarcoma of the liver. Pathologic findings and long-term survival after complete surgical resection. Cancer 1992 69 52-59... 

Serratia marcescens polysaccharide has been reported to be active against a number of other tumors, such as Sarcoma 180 (Ref. 22), Ehrlich carcinoma,22 Guerin carcinoma,23 Sarcoma M-l (Ref. 23), and Walker carcinosarcoma.24 Navashin and coworkers25 found that... 

A convenient synthesis was reported for l,3-bis(tetrahydro-2-fur-anyl)-5-fluorouracil (Thf2 FU), whose toxicity and antitumor activity were compared with Ftorafur (Thf-FU) and FU. The oral LDc in mice was approximately 3-fold greater than that observed for Thf-FU, ich was much less toxic than FU. Thf -FU slowly hydrolyzed to FU in vivo and showed significant antitumor effects at 0.15-0.45 mmol/kg (p.o.) against Ehrlich and AH-130 carcinomas, sarcoma 180, Yoshida sarcoma and Walker 256 carcinosarcoma. The most active in a series of 1-alkyIcarbamoyl derivatives of FU was the 1-jt-butylcarbamoyl compound, which gave an of... 

Cullen, B. M. and Walker, H. C. (1985) The effect of several anaesthetics on the blood pressure and heart rate of the mouse and on the radiation response of the mouse sarcoma RIF-1. Inti. J. Radiat. Biol. 48, 761-771. 

Within the last 10 years a great number of plants have been screened for antitumour active alkaloids. The two major groups involved in this search were the National Cancer Institute and a group of chemists and biologists at Eli Lilly and Co. Crude extracts and crystalline alkaloids were screened in vitro (cell cultures) and in vivo against sarcoma 180, Walker 256 intramuscular carcinosarcoma, Eagle s K.B. strain of human carcinoma of the nasopharynx, Lewis lung carcinoma, etc. The tests, which were reproducible, were made under standard conditions set up by the C.C.N.S.C. (Cancer Chemotherapy National Service Centre). 

A cytotoxic alkaloid from Boehmeria cylindrica (Urticaceae), active in cell cultures against Eagle s K.B. carcinoma of the nasopharynx, but inactive against sarcoma 180, adenocarcinoma 755, L-1210 leukaemia, and Walker carcinosarcoma, was identified as cryptopleurine (61) (67) is a close relative of tylocrebrine (68), from Tylophora crebrifolia (Asclepiadaceae), whose high activity against lymphoid leukaemia L-1210 in mice had been observed. ... 

Extracts of Jatropha gossypiifolia L. and related species have been used for many years in Costa Rica to treat cancerous growths. An alcoholic extract of the roots of Jatropha gossypiifolia (supplied by J. A. Saenz Renauld of the University of Costa Rica) was found by CCNSC to show inhibitory activity against four standard animal tumor systems (sarcoma 180, Lewis lung carcinoma, and lymphocytic leukemia P-388 in the mouse, and the Walker 256 intramuscular carcinosarcoma in the rat) and in vitro... 

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