Embryo fibroblasts

Kelley, P.M. Schlesinger, M.J. (1978). The effect of amino acid analogues and heat shock gene expression in chicken embryo fibroblasts. Cell 15, 1277-1286. 

Bond, U. Schlesinger, M.J. (1985). Ubiquitin is a heat shock protein in chicken embryo fibroblasts. Molecular and Cellular Biology, 5, 949-56. 

Nagata, K., Saga, S. Yamada, K.M. (1986). A major collagen-binding protein of chick embryo fibroblasts is a novel heat shock protein. Journal of Cell Biology, 103, 223-9. 

Although the initially reported tissue compatibility tests for subcutaneous implants of poly(BPA-iminocarbonate) were encouraging (41,42), it is doubtful whether this polymer will pass more stringent biocompatibility tests. In correspondence with the properties of most synthetic phenols, BPA is a known irritant and most recent results indicate that BPA is cytotoxic toward chick embryo fibroblasts in vitro (43). Thus, initial results indicate that poly(BPA-iminocarbonate) is a polymer with highly promising material properties, whose ultimate applicability as a biomaterial is questionable due to the possible toxicity of its monomeric building blocks. 

Initially, the cytotoxicity against chick embryo fibroblasts of BPA, tyrosine, tyrosine dipeptide, and the dipeptide derivatives used in the synthesis of the polymers shown in Fig. 7 were evaluated in a comparative experiment (43). The surface of standard tissue culture wells was coated with 5 mg of each test substance. Then the adhesion and proliferation of the fibroblasts was followed over a 7-day period. Among all test substances, BPA was clearly the most cytotoxic material. Monomeric tyrosine derivatives containing the ben-zyloxycarbonyl group were also cytotoxic, while tyrosine itself, tyrosine dipeptide, and most of the protected dipeptide derivatives did not noticeably interfere with cell growth and adhesion and were therefore classified on a preliminary basis as possibly "nontoxic."... 

Collier, N., and Schelsinger, M. J. (1986). The dynamic state of heat shock proteins in chicken embryo fibroblasts. J. Cell Biol. 103, 1495—1507. 

Rat mammary tumors Lewis lung cancers Mouse mammary tumors Choriocarcinoma cells Anaplastic sarcomas Walker carcinoma cells Rat prostatic carcinomas Rat embryo fibroblasts Different malignant cells... 

Gomez-Duran A, Mulero-Navarro S, Chang X, Fernandez-Salguero PM LTBP-1 blockade in dioxin receptor-null mouse embryo fibroblasts decreases TGF-(5 activity role of extracellular proteases plasmin and elastase. J Cell Biochem 2006 97 380-392. 

The concentration of toxin which causes a 50% reduction in cell bound dye after five days in culture. Cell lines used were H4TG, thioguanine-resistant rat hepatoma cells MDCK, Madin-Darb and canine kidney cells NIH3T3,NIH Swiss mouse embryo fibroblasts and KA31T, Kirsten strain of Moloney sarcoma virus-transformed 3T3 cells. 

Vedel, M., Lawrence, F., Robert-Gero, M. and Lederer, E. (1978) The antifungal antibiotic sinefungin as a very active inhibitor of mefhyltransferases and of the transformation of chick embryo fibroblasts by Rous sarcoma virus. Biochemical and Biophysical Research Communications, 85, 371-376. 

Basu A, Cline JS (1995) Oncogenic transformation alters cisplatin induced apoptosis in rat embryo fibroblasts. Int J Cancer 63 597-603 Basu A, Weixel KM (1995) Comparison of protein kinase C activity and isoform expression in cisplatin-sensitive and -resistant ovarian carcinoma cells. Int J Cancer 62 457-460... 

Schiffmann D, Reichert D, Henschler D. 1984. Induction of morphological transformation and unscheduled DNA synthesis in Syrian hamster embryo fibroblasts by hexachlorobutadiene and its putative metabolite pentachlorobutenoic acid. Cancer Lett 23 297-305. 

Mouse embryo fibroblasts Cell transformation — Miuraetal. 1989 Nickel sulfate, nickel chloride... 

Fernandez, A., Mondal, S., and Heidelberger, C. (1980). Probabilistic view of the transformation of cultrued C3H/10T1/2 mouse embryo fibroblasts by 3-methylchoanthrene, Proc. Natl. Acad. Sci, 77,7272. 

Land, H., Parada, L.G., and Weinberg, R.A. (1983b). lUmorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes, Nature 304,596. 

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