Edetate disodium calcium

Edetate calcium disodium Calcium Disodium Versenate) Lead... [Pg.369]

Dimercaprol, edetate calcium disodium, D-Penicillamine, succimer... [Pg.372]

Poisoning, lead (mild) IM Initially, 4 mg/kg, then 3 mg/kg q4h for 2-7 days in combination with edetate calcium disodium injection at different injection sites. Poisoning, lead (severe) IM 4 mg/kg q4h for 2-7 days in combination with edetate calcium disodium injection at different injection sites. [Pg.378]

Dimercaprol is FDA-approved as single-agent treatment of acute poisoning by arsenic and inorganic mercury and for the treatment of severe lead poisoning when used in conjunction with edetate calcium disodium (EDTA see below). Although studies of its metabolism in humans are limited, intramuscularly administered dimercaprol appears to be readily absorbed, metabolized, and excreted by the kidney within 4-8 hours. Animal models indicate that it may also undergo biliary excretion, but the role of this excretory route in humans and other details of its biotransformation are uncertain. [Pg.1240]

EDETATE CALCIUM DISODIUM (ETHYLENEDIAMINETETRAACETIC ACID, EDTA)... [Pg.1241]

Edetate calcium disodium is indicated chiefly for the chelation of lead, but it may also have usefulness in poisoning by zinc, manganese, and certain heavy radionuclides. In spite of repeated claims in the alternative medicine literature, EDTA has no demonstrated usefulness in the treatment of atherosclerotic cardiovascular disease. [Pg.1241]

Abbreviations. BHA, butylated hydi oxyanisole BHT, butylated hydroxytoluene EDTA, edetate calcium disodium. [Pg.173]

Higher concentrations of a chemical entity may cause a pharmacological response whereas lower concentrations are incapable of doing so. For example, edetate calcium disodium (9) at a formulated concentration of 20% is indicated as a drug for the treatment of lead poisoning and lead encephalopathy while it can be found commonly present as an excipient in concentrations ranging from 0.01% to 0.1% in parenteral formulations to prevent oxidation of the active ingredient. [Pg.358]

Edetic acid Edetate sodium Edetate disodium Edetate trisodium Edetate calcium disodium... [Pg.60]

Edetic acid is obtained as crystals from water Edetate sodium is a powder Edetate disodium is composed of dihydrate crystals Edetate trisodium is obtained as monohydrate crystals from water Edetate calcium disodium is a tetrahydrate powder. All materials are white in color, and odorless. [Pg.61]

Edetate calcium disodium soluble in water a 0.1 M solution ( 37 g/L) can be prepared at 30°C. Practically insoluble in organic solvents. [Pg.63]

The USP [2] describes the following identification tests for edetic acid, edetate disodium and edetate calcium disodium. [Pg.79]

Edetic acid (EDTA), edetate disodium, and edetate calcium disodium are the subjects of three monographs in the United States Pharmacopoeia (USP) [2]. Only disodium edetate is official in the British Pharmacopoeia (BP) [3]. [Pg.80]

B. The infrared absorption spectrum of a mineral oil dispersion of sample exhibits maxima only at the same wavelengths as those of a similar preparation of USP Edetate Calcium Disodium Reference Standard. [Pg.65]

SYNS CALCIUM DISODIUM EDETATE CALCIUM DISODIUM ETHYLENEDIAMINETETRAACETATE CALCIUM DISODIUM (ETHYLENEDINITRILO)-TETRAACETATE... [Pg.269]

Disodium edetate is used widely in topical, oral, and parenteral pharmaceutical formulations it is used extensively in cosmetic and food products. Disodium edetate and edetate calcium disodium are used in a greater number and variety of pharmaceutical formulations than is edetic acid. Both disodium edetate and edetate calcium disodium are poorly absorbed from the gastrointestinal tract and are associated with few adverse effects when used as excipients in pharmaceutical formulations. [Pg.256]

Disodium edetate, trisodium edetate, and edetic acid readily chelate calcium and can, in large doses, cause calcium depletion (hypocalcemia) if used over an extended period of time, or if administered too rapidly by intravenous infusion. If used in preparations for the mouth, they can also leach calcium from the teeth. However, edetate calcium disodium does not chelate calcium. [Pg.256]

Edetic acid and edetate salts are used in pharmaceutical formulations, cosmetics, and foods as chelating agents. They form stable water-soluble complexes (chelates) with alkaline earth and heavy metal ions. The chelated form has few of the properties of the free ion, and for this reason chelating agents are often described as removing ions from solution this process is also called sequestering. The stability of the metal-edetate complex depends on the metal ion involved and also on the pH. The calcium chelate is relatively weak and will preferentially chelate heavy metals, such as iron, copper, and lead, with the release of calcium ions. For this reason, edetate calcium disodium is used therapeutically in cases of lead poisoning see also Section 18. [Pg.260]

Edetic acid and disodium edetate may also be used as water softeners since they will chelate the calcium and magnesium ions present in hard water edetate calcium disodium is not effective. Many cosmetic and toiletry products, e.g., soaps, contain edetic acid as a water softener. [Pg.260]

Although edetic acid is fairly stable in the solid state, edetate salts are more stable than the free acid, which decarboxylates if heated above 150°C. Disodium edetate dihydrate loses water of crystallization when heated to 120°C. Edetate calcium disodium is slightly hygroscopic and should be protected from moisture. [Pg.261]

Other incompatibilities include the inactivation of certain types of insulin due to the chelation of zinc, and the chelation of trace metals in total parenteral nutrition (TPN) solutions following the addition of TPN additives stabilized with disodium edetate. Calcium disodium edetate has also been reported to be incompatible with amphotericin and with hydralazine hydrochloride in infusion fluids. [Pg.261]

Edetates, particularly disodium edetate and edetate calcium disodium, are used in a greater number and variety of pharmaceutical formulations than the free acid. [Pg.261]

Edetate calcium disodium is nephrotoxic and should be used with caution in patients with renal impairment. [Pg.261]

Dipotassium edetate disodium edetate edetate calcium disodium sodium edetate trisodium edetate. [Pg.261]

Synonyms calcium disodium edetate calcium disodium ethylenediaminetetraacetate calcium disodium (ethylene-dinitrilo)tetraacetate E385 edathamil calcium disodium edetic acid calcium disodium salt EDTA calcium ethylene-diaminetetraacetic acid calcium disodium chelate [(ethyl-enedinitrilo)tetraacetato]calciate(2-) disodium sodium calciumedetate Nersene CA. [Pg.262]

Method of manufacture edetate calcium disodium may be prepared by the addition of calcium carbonate to a solution of disodium edetate. [Pg.262]

Comments used in pharmaceutical formulations as a chelating agent in concentrations between 0.01-0.1% w/v. Usually edetate calcium disodium is used in pharmaceutical formulations in preference to disodium edetate or sodium edetate to prevent calcium depletion occurring in the body. In food products, edetate calcium disodium may also be used in flavors and as a color retention agent. Edetate calcium disodium occurs as the dihydrate, trihydrate, and anhydrous material. [Pg.262]

Some pharmacopeias specify that edetate calcium disodium is the dihydrate, others that it is the anhydrous material. The USP 28 specifies that edetate calcium disodium is a mixture of the dihydrate and trihydrate but that the dihydrate predominates. [Pg.262]

Big Chemical Encyclopedia

Chemical substances, components, reactions, process design ...