Uncaria tomentosa, alkaloids

Evidence in favor of such a hypothesis is given by Jurgensen et al. who have first reported the fact that an alkaloid fraction from Uncaria tomentosa (Willd.) DC, a vine used by Peruvian Indians to treat several diseases, given by the intraperitonneal route, dose-dependently suppressed the behavioral response to the chemical stimuli in the models indicated and increased latencies in the thermal stimuli models (33). [Pg.100]

Wurm, M., L. Kacani, G. Laus, K. Keplinger, and M. P. Dierich. 1998. Pentacyclic oxindole alkaloids from Uncaria tomentosa induce human endothelial cells to release a lymphocyte proliferation regulating factor. Planta Med. 64 701-704. [Pg.325]

Alkaloid—Rhynchophylline Rubiaceae Uncaria tomentosa DC Jones (1994) Hemingway and Phillipson (1974))... [Pg.284]

Uncaria tomentosa (cat s claw), an herb from the highlands of the Peruvian Amazon, contains the spiroindole alkaloids isopteropodine and rynchophylline it has immunomodulatory properties and has been used to treat arthritis and inflammatory bowel disease (7). [Pg.3086]

Lopez-Avila V, Benedicto J, Robaugh D. Supercritical fluid extraction of ox-indole alkaloids from Uncaria tomentosa. J High Resolut Chromatogr 1997 20 231-236. [Pg.570]

Another bioactive plant from South America, occurring in the upper reaches of the Amazon in Peru, is colloquially known as cat s claw, or Una de Gato Uncaria tomentosa.of the family Rubiaceae). Anecdotal evidence describes some remarkable cancer cures using a tea made from this plant, and it is available in the United States. The action may be due to the presence of alkaloids, but one is not entirely convinced. [Pg.276]

Uncariae tomentosae cortex, (alkaloid extraction method B, 40jil)... [Pg.31]

Cat s claw (Uncaria tomentosa and Uncaria guianensis), an herbal medicine from the Amazon, is widely used to treat inflammatory disorders. Both species of cat s claw provide effective antioxidant and anti-inflammatory activities, but Uncaria guianensis is the more potent of the two. Non-alkaloid fractions from both species have been found to decrease lipopolysaccharide (LPS)-induced TNF-a and nitrite production in RAW 264.7 cells, and oral pretreatment for 3 days with Uncaria tomentosa actually prevented TNFa mRNA expression and apoptosis. Interestingly, the pharmacological properties of these species do not seem to be dependent on the presence of oxindole or pentacyclic alkaloids [191]. [Pg.181]

Bacher, N., M. Tiefenthaler, S. Sturm, et al. 2006. Oxindole alkaloids from Uncaria tomentosa induce apoptosis in proliferating, Go/Gi-arrested and bcl-2-expressing acute lymphoblastic leukaemia cells. Br. J. Haematol. 132(5) 615-622. [Pg.895]

Garcia Prado, E., M.D. Garcia Gimenez, R. De la Puerta Vazquez, J.L. Espartero Sanchez, and M.T. Saenz Rodriguez. 2007. Antiproliferative effects of mitraphylline, a pentacyclic oxindole alkaloid of Uncaria tomentosa on human glioma and neuroblastoma cell lines. Phytomedicine 14(4) 280-284. [Pg.895]

Laus, G., D. Brossner, and K. Keplinger. 1997. Alkaloids of Peruvian Uncaria tomentosa. Phytochemistry 45 855-860. [Pg.895]

Mur, E., F. Hartig, G. Eibl, and M. Schirmer. 2002. Randomized double blind trial of an extract from the pentacyclic alkaloid-chemotype of Uncaria tomentosa for the treatment of rheumatoid arthritis. J. Rheumatol. 29(4) 678-681. [Pg.895]

IV-oxide of H. occurs in Uncaria tomentosa. H. with a 2l -double bond is known as hirsuteine. H. has blood vessel and muscle relaxing properties. H. also shows activity against influenza A viruses. - c) An isoquinoline alkaloid from Cocculus species, C19H23NO4, Mr 329.40. - d) 3,5-Bis-j8-D-glucopyranosyloxy-4 -hydroxy-3, 5, 7-trlmethoxyflavylium, C3oH3,0 7, Mr 669.61... [Pg.292]

Huerta-Heredia AA, Marin-Lopez R, Ponce-Noyola T, Cerda-Garcia-Rojas CM, Treijo-Tapia G, Ramos-Valdivia AC. Oxidative stress induces alkaloid production in Uncaria tomentosa root and cell cultures in bioreactors. Eng Life Sci 2009,9 (3) 211-8. [Pg.406]

Pilarski R, Filip B, Wietrzyk J, Kuras M, Gulewicz K (2010) Anticancer activity of the Uncaria tomentosa (Willd.) DC. Preparations with different oxindole alkaloid composition. Phytomedicine 17 1133-1139. doi 10.1016/J.phymed.2010.04.013... [Pg.142]

Sandoval M, Okuhama NN, Zhang XJ, Condezo LA, Lao J, Angeles FM, Musah RA, Bobrowski P, Miller MJS (2002) Anti-inflammatory and antioxidant activities of cat s claw (Uncaria tomentosa and Uncaria guianensis) are independent of their alkaloid content Phytomedicine 9 325-337. doi 10.1078/0944-7113-00117... [Pg.142]

Kuras M, Pilarski R, Nowakowska J, Zobel A, Brzost K, Antosiewicz J, Gulewicz K (2009) Effect of alkaloid-free and alkaloid-rich preparations from Uncaria tomentosa bark on... [Pg.142]

Wagner H, Kreuzkamp B, Jurcic K (1985) Die Alkaloide von Uncaria tomentosa und ihre Phagozytosesteigernde Wirkung. Planta Med 419-423... [Pg.35]

Hiermann (1995) used different flavonoid patterns to distinguish Epilobium angustifolium from 11 other species of Epilobium by TLC on silica gel and polyamide and HPLC coupled with photodiode array detection. Rustan et al. (1995) developed TLC methods to determine flavonoids extracted from Mediterranean plants of the Labiatae group. Van Ginkel (1996) used TLC to identify alkaloids and flavonoids from the bark of Uncaria tomentosa. [Pg.356]

N CP-MAS NMR of Stereoisomeric Oxindole Alkaloids from Cat s Claw (Uncaria tomentosa)... [Pg.32]

K. Paradowska, M. Wolniak, M. Pisklak, J.A. Ghhski, M.H. Davey, I. Wawer, C, N CPMAS NMR and GIAO DFT calculations of stereoisomeric oxindole alkaloids from cat s claw (Uncaria tomentosa), Sohd State NMR 34 (2008) 202—209. [Pg.73]

I. Muhammad, D.C. Dunbar, R.A. Khan, M. Ganzera, LA. Khan, Investigation of Una de gato 1. 7-Deoxyloganic acid and 15N NMR spectroscopic studies on penta-cyclic oxindole alkaloids from Uncaria tomentosa. Phytochemistry 57 (2001) 781—785. [Pg.73]

Uncaria tomentosa (Cat s claw, Vilcacora) is a large, woody vine, indigenous to the Amazon rainforest. Numerous investigations have been carried out to isolate and determine its bioactive components. In particular, oxindole alkaloids (mitraphylline, isomitraphylline, speciophylline. [Pg.1500]

Paradowska K, Wolniak M, Pisklak M, Glinski J, Davey M, Wawer I. C, N CP MAS NMR and CIAO DPT calculations of stereoisomeric oxindole alkaloids from Cat s claw Uncaria tomentosa). Solid State Nucl. Magn. Reson. 2008 34 202 209. [Pg.1504]

Numerous bioactive alkaloids have been isolated from Uncaria [35—47], but two species yielded a considerable number of active compounds U. rhynchophylla and U. tomentosa. [Pg.124]

Activity Against Vascular Dementia and Ischemia Structural Diversity of Compounds from Uncaria spp. 401 Structure and Activity Relationship of Bioactive Compounds from Uttcaria spp. 402 Alkaloid Biosynthesis in U. tomentosa 403... [Pg.379]

Various parts of Uncaria plants are conunraily used in the traditional medicine for the treatment of inflammatory diseases, fii a study, hydro-alcoholic extract (Et0H-H20) and an aqueous extract of bark of U. tomentosa have been analyzed for their antUnflaminatoiy activity [64]. The hydro-alcoholic extract exhibited higher activity in mouse paw edema model and suppressed NF-kB [64]. Phytochemical analysis of these extracts revealed that hydroalcoholic extract possesses higher oxindole alkaloid content than the aqueous extract. It is believed that the antiinflammatory activity of U. tomentosa is attributed to the synergistic effect from a combination of these compounds [64]. [Pg.395]

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