T-cell leukemia-lymphoma

Lymphomas not included in Working Formulation mycosis fungoides, mantle cell lymphoma, monocytoid B-cell lymphoma, mucosa-associated lymphoid tissue (MALT), anaplastic large cell lymphoma, angiocentric lymphoma, angioimmunoblastic lymphadenopathy (AILD), Castleman s disease, adult T-cell leukemia/lymphoma. 

Ishida T, Iida S, Akatsuka Y, et al. The CC chemokine receptor 4 as a novel specific molecular target for immunotherapy in adult T-cell leukemia/lymphoma. Clin Cancer Res 2004 10 7529-7539. 

K3. Kinoshita, K., Kamihira, S., Yamada, Y, Amagasaki, T., Ikeda, S., Momita, S., and Ichimaru, M., Adult T-cell leukemia-lymphoma in the Nagasaki district. In Adult T-Cell Leukemia and Related Disease (M. Hanaoka, K. Takatsuki, and M. Shimoyama, eds.), pp. 167-184. Japan Scientific Societies Press, Tokyo, 1982. 

Shimoyama, M., Diagnostic criteria and classification of clinical subtypes of adult T-cell leukemia-lymphoma. A report from the Lymphoma Study Group (1984-87). Br. J. Haematol. 79,428-437 (1991). 

T/NK (natural killer) cell lymphomas are much less common in Western countries and much less understood than the B cell lymphomas. Thus, the discussion of these entities will be much briefer. In addition, a significant number of the T/NK lymphomas, such as enteropathy-type T cell lymphoma, hepatosplenic T cell lymphoma, subcutaneous panniculitis-like T cell lymphoma, blastic NK cell lymphoma, T cell granular lymphocytic leukemia, and adult T cell leukemia/ lymphoma, will not be discussed in this review. The reader is advised to consult the recent World Health Organization Classification of Tumours (J2). 

Mahieux R, Gessain A. HTLV-1 associated adult T-cell leukemia/lymphoma. Rev Clin Exp Hematol 2003 7 336-61. 

Kazanji M, Tai taglia J, Franchini G, de Tlioisy B, Talaimiii A, Coii-tamin H, Gessain A, de Tlie G (2001) Immuiiogenicity and pro-tecdve efficacy of recombinant human T-cell leukemia/lymphoma virus type 1 NYVAC and naked DNA vaccine candidates in squirrel monkeys (Saimiri sciureus). J Virol 75 5939—5948. 

Usuku K, Sonoda S, Osame M, Yashiki S, Takahashi K, Matsumoto M, SawadaT, Tsuji K, TaraM, Igata A (1988) HLAliaplo type-linked high immune responsiveness against HTLV-I in HTLV-I-associated myelopadiy Comparison widi adult T-cell leukemia/lymphoma. Ann Neui-ol 23(Suppl) S 143-150. 

Since 1980 three types of infectious human T-cell lymphotrophic viruses (HTLVs) have been identified. HTLV-I is frequently associated with adult forms of T-cell leukemia-lymphoma, HTLV-II with hairy T-cell leukemia, and HTLV-III (now called human immunodeficiency virus HIV) with acquired immunodeficiency syndrome (AIDS). Other related retroviruses have been isolated from human and primate populations. Molecular biologists have developed a wealth of information about the biology and genetics of retroviruses, including the complete sequencing of their genomes. Despite this enormous research effort it still... 

Ohshima K, Kikuchi M, Shibata T, et al. Clonal analysis of Hodgkin s disease shows absence of TCR/Ig gene rearrangement, compared with T-cell-rich B-cell lymphoma and incipient adult T-cell leukemia/lymphoma. Leuk Lymphoma. 1994 15 469-479. 

The protein p56 lymphoid T-cell tyrosine kinase (Lck) is predominantly expressed in T lymphocytes where it plays a critical role in T-cell-mediated immune response. Lck participates in phosphotyrosine-dependent protein-protein interactions through its modular binding unit, the Src homology-2 (SH2) domain. SH2 domains are noncatalytic modules of about 100 amino acid residues that play important roles in intracellular signal transduction and represent potential targets for pharmacological intervention. Failure of the p5 6 Lck S H 2 domain to bind to immunoreceptor tyrosine-based activation motifs (ITAMs) of CD3 hampers the T-cell receptor (TCR) proximal activation process and suppresses the downstream T-cell activation signaling cascades [143]. Small compounds that would be able to block Lck SH2 domain-dependent protein-protein interactions could find therapeutic utility as immunosuppressants and in the treatment of T-cell leukemias, lymphomas, and autoimmune diseases such as rheumatoid arthritis. 

ElUott NE, Cleveland SM, Giann V, Janik J, Waldmann TA, Dave UP. EERM domain mutations induce gain of function in JAK3 in adult T-cell leukemia/lymphoma. Blood. 2011 118 3911-21. 

Clinical significance of CCR4 expression in adult T-cell leukemia/lymphoma Its close association with skin involvement and unfavorable outcome. Clin. Cancer Res. 9, 3625-3634. 

Ozden S, Cochet M, Mikol J et al. (2004) Direct evidence for a chronic CDS -I- -T-cell-mediated immune reaction to tax within the muscle of a human T-cell leukemia/lymphoma virus type 1-infected patient with sporadic inclusion body myositis. J Virol 78, 10320-10327. 

Weinberg, J.B., D.L. Blazey, T.J. Matthews, B.F. Haynes, T.J. Palker, R.A. Spiegel, R.A. Meriwether, J.N. MacCormack, M. Robert-Guroff, and M. Popovic. 1987. Adult T-cell leukemia/lymphoma associated with human T-lymphotropic virus type I (HTLV-I) infection—North Carolina. Morbid. Mortal. Weekly Rep. 36 804-806, 812. 

Marsh BJ. Infectious comphcations of human T cell leukemia/lymphoma virus type I infection. Clin Infect Dis 1996 23 138-145. 

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