T-cell leukemia

Retroviruses Human T-cell leukemia virus (HTLV) Human T-lymphocytic tumors... 

Lymphomas not included in Working Formulation mycosis fungoides, mantle cell lymphoma, monocytoid B-cell lymphoma, mucosa-associated lymphoid tissue (MALT), anaplastic large cell lymphoma, angiocentric lymphoma, angioimmunoblastic lymphadenopathy (AILD), Castleman s disease, adult T-cell leukemia/lymphoma. 

Niwa R, Shoji-Hosaka E, Sakurada M, et al. Defucosylated chimeric anti-CC chemokine receptor 4 IgGl with enhanced antibody-dependent cellular cytotoxicity shows potent therapeutic activity to T-cell leukemia and lymphoma. Cancer Res 2004 64 2127-2133. 

Ishida T, Iida S, Akatsuka Y, et al. The CC chemokine receptor 4 as a novel specific molecular target for immunotherapy in adult T-cell leukemia/lymphoma. Clin Cancer Res 2004 10 7529-7539. 

Adult T-cell leukemia Human T-cell Retrovirus RNA... 

Kalyanaraman, D. Mann, G. D. Sidhu, R. E. Stahl, S. Zolla-Prazner, J. Leibowitch, and M. Popovic, Isolation of human T-cell leukemia virus in acquired immune deficiency syndrome (AIDS), Science 220 865 (1983). 

Pentostatin (2,-deoxycoformycin) is an adenosine analog that is a potent inhibitor of adenosine deaminase. Pentostatin is particularly useful for treating T-cell leukemia since malignant T cells have higher levels of adenosine deaminase than most cells. Similar to individuals that are genetically deficient in adenosine deaminase, treat-... 

Peno statin Adenosine analog T-cell leukemia Inhibits adenosine deaminase suppresses T and B cells... 

HTLV I Endemic in W Indies and SW Japan transmission via blood, human milk can cause adult T-cell leukemia, and HTLV I-associated myelopathy and tropical spastic paraparesis... 

HTLV II Uncommon, sporadic occurence transmission via blood can cause hairy T-cell leukemia... 

While dEpoB performed similarly to paclitaxel in sensitive tumor xenografts (MX-1 human mammary and HT-29 colon tumor), clearly superior effects of dEpoB were observed against MDR tumors under these slow infusion conditions. Thus, dEpoB (6 h, Q2D, 30 mg/kg x 5 doses, i.v.) demonstrated a foil curative effect when administered to nude mice bearing the resistant human lymphoblastic T-cell leukemia,... 

Kobe B, Center RJ, Kemp BE, Poumbouris P. 1999. Crystal structure of human T cell leukemia virus type 1 gp21 ectodomain crystallized as a maltose binding protein chimera reveals structural evolution of retroviral transmembrane proteins. Proc Natl Acad Sci USA 96 4319-4324. 

MM = multiple myeloma ATL = adult T-cell leukemia ALL = acute lymphoblastic leukemia CLL = chronic lymphocytic leukemia FCC = follicular center cell lymphoma DLC = diffuse large cell lymphoma TRB = T-cell rich B-cell lymphoma ALCL = anaplastic large cell lymphoma MALT = mucosa-associated lymphoid tissue-type lymphoma LC = lung cancer CMM = cutaneous malignant melanoma TCC = transitional cell carcinoma CSCC = cutaneous squamous cell carcinoma. 

K3. Kinoshita, K., Kamihira, S., Yamada, Y, Amagasaki, T., Ikeda, S., Momita, S., and Ichimaru, M., Adult T-cell leukemia-lymphoma in the Nagasaki district. In Adult T-Cell Leukemia and Related Disease (M. Hanaoka, K. Takatsuki, and M. Shimoyama, eds.), pp. 167-184. Japan Scientific Societies Press, Tokyo, 1982. 

K5. Knipping, E., Debatin, K. M., Strieker, K., Heilig, B., Eder, A., and Krammer, P. H., Identification of soluble APO-1 in supernatants of human B- and T-cell lines and increased serum levels in B- and T-cell leukemias. Blood 85, 1562-1569 (1995). 

Shimoyama, M., Diagnostic criteria and classification of clinical subtypes of adult T-cell leukemia-lymphoma. A report from the Lymphoma Study Group (1984-87). Br. J. Haematol. 79,428-437 (1991). 

T2. Tamiya, S., Ftoh, K., Suzushima, H., Takatsuki, K., and Matsuoka, M., Mutation of CD95 (Fas/Apo-1) gene in adult T-cell leukemia cells. Blood 91, 3935-3942 (1998). 

Kasai T, Iwanaga Y, Iha H et al. Prevalent loss of mitotic spindle checkpoint in adult T-cell leukemia confers resistance to microtubule inhibitors. JBiol Chem 2002 277 5187-5193. 

---