Glycidyl phenyl ether

Kirwin CJ Jr, Sandmeyer EE Ethers. In Clayton GD, Clayton EE (eds) Patty s Industrial Hygiene and Toxicology, 3rd ed, Vol 2 A, Toxicology, pp 2541-2543. New York, Wiley-Interscience, 1981 

Haworth S, Lawlor T, Mortelmans K et al Salmonella mutagenicity test results for 250 chemicals. Environ Mutagen 5(suppl 1) 3-142, 1983 

Chemical intermediate with high solvency for halogenated materials 

Toxicology. Phenyl glycidyl ether (PCE) is an irritant of mucous membranes and skin and causes sensitization it has caused nasal tumors in experimental animals. 

Of 20 workers exposed to PCE, 13 had acute skin changes, including second-degree burns, vesicular rash, papules, and edema. In another study of 15 workers with PCE-induced dermatitis, there was erythema with papules and vesicles. Of these 15 workers, 8 reacted positively to patch tests. In addition to skin sensitization PGE can also cause crosssensitization with other glycidyl ethers. 

122-60-1 Systematic name (Phenoxymethyl)oxirane 

2 Structural and molecular formulae and relative molecular mass 

Pure phenyl glycidyl ether was tested for carcinogenicity by inhalation exposure in male and female rats of one strain, producing carcinomas of the nasal cavity in animals of each sex (lARC, 1989). 

Other Data Relevant to an Evaluation of Carcinogenicity and its Mechanisms 

Percutaneous absorption of phenyl glycidyl ether is high in rats and rabbits. It binds to glutathione in the presence of liver microsomes from various avian species (lARC, 1989). 

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Phenylethylene, see Styrene, monomer Phenyl glycidyl ether (PGE) 1 6.1... 

The preferred catalysts are salts of inorganic and organic acids as well as tertiary amines. Phthalic anhydride, succinic anhydride and maleic anhydride are typical acid anhydrides, while ethylene oxide, propylene oxide, epichlorohydrin and phenyl glycidyl ether are typical epoxides. The synthesis of a ladder polymer was carried out by using bisanhydrides264. ... 

In another study that appeared prior to the advent of CASTing, the traditional combination of epPCR and DNA shuffling was used to enhance the enantioselectivity of the hydrolytic kinetic resolution of p-nitro phenyl glycidyl ether and other epoxides catalyzed by the EH from Agrobacterium radiobacter [59]. Several mutants were obtained with up to 13-fold improved enantioselectivity. The amino acid exchanges took place around the active site. 

FIGURE 24.4 Master curves of the local segmental relaxation times for 1,4-polyisoprene (-y = 3.0) 1,2-polybutadiene (7=1.9) polyvinylmethylether (7 = 2.55) polyvinylacetate (7 = 2.6) polypropylene glycol (7 = 2.5) polyoxybutylene (7 = 2.8) poly(phenyl glycidyl ether)-co-formaldehyde (7 = 3.5) polymethylphe-nylsiloxane (7 = 5.6) poly[(o-cresyl glycidyl ether)-co-formaldehyde] (7 = 3.3) and polymethyltolylsiloxane (PMTS) (7 = 5.0) [15 and references therein]. Each symbol for a given material represents a different condition of T and P. 

Phenyl glycidyl ether Phenylhydrazine Phenyloxirane Phosdrin... 

Phenyl ether (vapour) Phenyl glycidyl ether... 

Tang, Y.-F., Xu, J.-H., Ye, Q. and Schulze, B. (2001) Biocatalytic preparation of (S)-phenyl glycidyl ether using newly isolated Bacillus megaterium ECU1001. Journal of Molecular Catalysis B Enzymatic, 13, 61-68. 

Phenyl formate, physical properties, 6 292t Phenyl glycidyl ether (PGE), 10 376 AT-Phenylglycine, 1 138 9 279 AT-Phenylglycinonitrile, 3 174 Phenylhydrazine synthesis, 13 573 Phenylhydrazone cleavage, microwaves in, 16 562... 

Materials. Reagent grade solvents, dimethyl formamide (DMF), dimethyl acetamide (DMAC), dimethyl sulfoxide (DMSO) and methanol were purchased from Baker, stored over molecular sieves once opened, and used without further purification. Aminoethane thiosulfuric acid (AETSA) purchased from Kodak, and Taurine, purchased from Alfa were purified by recrystallization. Each was thrice recrystallized from hot, deionized water. The crystalline precipitate was dried (48 hours at 40 °C) in-vacuo and subsequently stored in a desiccator. Benzophenone (BP) was purchased from Aldrich Chemical Company. QUANTACURE BTC (BTC), (4-benzolybenzyl) trimethylammonium chloride, was used as supplied by Aceto, Inc., Flushing, New York. Phenyl glycidyl ether (PGE) was purchased from MCB, distilled in-vacuo. and stored at -15 °C. Epon 828 was used as supplied bv Shell Chemical Company. The epoxy equivalent weight (EEW) for Epon 828 determined by an appropriate titration, was found to be 187.7. 

A technician who handled both IGE and phenyl glycidyl ether developed localized dermatitis on the back of the hands patch testing showed sensitization to both substances. Dermatitis has occurred in workers with repeated skin contact ... 

The 2003 ACGIH threshold limit valuetime-weighted average (TLV-TWA) for phenyl glycidyl ether is 0.1 ppm (0.6mg/m ) with an A3-animal carcinogen designation. 

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