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Substitution reactions nucleophile

SNase, see Staphylococcal nuclease (SNase) S,v2 reactions, see Substitution reactions, nucleophilic (Sw2)... [Pg.235]

Know the meaning of nucleophilic substitution reaction, nucleophile, substrate, leaving group. [Pg.111]

Why are the differences in nucleophilicity relatively the same over many different substitution reactions Nucleophilicity describes the ability of the nucleophile to make an electron pair available to the electrophile (i.e., the alkylating agent). With this as the basic idea, the experimentally observable nucleophilicity trends can be interpreted as follows. [Pg.54]

Nucleophilic substitution reactions. Nucleophilic displacement of a halogen In compounds such as 2-acetamldo-4-chloromethylthlazole under reflux of an alkaline ethanol solution Is a straight foreward reaction (219). Nucleophilic aromatic substitution reactions are more complex but under certain conditions they can be used for single step synthesis of aryl methyl sulfides. A number of 4-methylthlo-polychlorobiphenyls were synthesized from... [Pg.144]

Ketyls generated by the reaction of SmE with aldehydes and ketones have been incorporated into numerous sequential processes in which a radical reaction is involved. Sequential radical processes, radical cyclization/carbonyl additions, radical cyclization/substitution reactions, nucleophilic acyl substitution/radical cyclizations, cyclization/elimination processes, and others have all been realized. Because these types of reactions have been extensively reviewed [2b, 25], further details will not be given here. Needless to say, new sequential processes based on SmE-promoted ketyl/olefin coupling reactions are still being developed (Eq. 75) [88]. [Pg.172]

Substitution Reactions. Nucleophilic substitution of groups attached to the 4-position takes place readily. Thus it proved easy to effect nucleophilic replacement of a 4-methoxy group by an ethoxy or a hydroxy group [140]. Similarly nucleophilic substitution of a halogen atom attached to the seven-membered ring proceeds readily in contrast, if the halogen atom is attached to the five-membered ring substitution only takes place to a small extent [95],... [Pg.418]

The rates of reactions proceeding by an associative mechanism must depend to some degree on the nature of the entering group. The usual parameter which is referred to in substitution reactions is the nucleophilicity of ligand or nucleophile (which is a measure of the effectiveness of the nucleophile in a substitution reaction). Nucleophilicity is a kinetic term, while basicity is thermodynamic in origin. There is often a relationship... [Pg.95]

Other Nucleophilic Substitution Reactions. Nucleophilic substitution of a variety of substituted aminoiminomethanesulfonic acids with cyanide leads to the corresponding aminoimi-noethanenltrlles in 30-87% yield. A number of substituted aminoiminomethanesulfonic acids react with sodium azide in acetic acid to give the corresponding 5-aminotetrazole. This reaction Is subject to pronounced steric hindrance. Hydroxyl-amine and cyanamlde also give nucleophilic substitution of the sulfonic acid group. ... [Pg.17]

Aryl halides are less reactive than alkyl halides in nucleophilic substitution reactions. Nucleophilic substitution in aryl halides is facilitated by the presence of a strong electron-withdrawing group, such as NOj, ortho or para to the halogen. [Pg.499]

A considerable number of ring-fluorinated diazines undergoes various nucleophilic aromatic substitution reactions. Nucleophilic aromatic substitution reactions follow the well-established two-step addition-elimination mechanism via a Meisenheimer intermediate. The destabilization of sp -C bound fluorine by p-Jt repulsion activates fluorinated aromatic compounds toward nucleophilic attack and subsequent substitution. The susceptibility of the carbon center toward nucleophiles is also enhanced by the negative inductive (-la) effect of fluorine. Therefore the ease of nucleophilic halogen replacement - F>Cl>Br>I - is in the opposite order to that for aliphatic... [Pg.326]

As the reaction shown in the scheme above is a nucleophilic substitution reaction, nucleophilicity of oxygen atoms in monomers and polymer units is an important factor governing the competition between chain propagation and chain transfer to polymer. [Pg.143]


See other pages where Substitution reactions nucleophile is mentioned: [Pg.130]    [Pg.230]    [Pg.235]    [Pg.137]    [Pg.16]    [Pg.417]    [Pg.123]    [Pg.272]    [Pg.471]    [Pg.590]    [Pg.638]    [Pg.197]   
See also in sourсe #XX -- [ Pg.211 , Pg.212 , Pg.213 , Pg.217 , Pg.218 ]

See also in sourсe #XX -- [ Pg.211 , Pg.212 , Pg.213 , Pg.217 , Pg.218 ]




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2-Chlorobenzoxazole, nucleophilic substitution reactions

5-Adenosylmethionine nucleophilic substitution reaction

A Substitution, Nucleophilic, Bimolecular The Sn2 Reaction

Abbreviated mechanism, nucleophilic acyl substitution reactions

Acetals nucleophilic substitution reaction

Acetate reactions nucleophilic substitution

Acid Derivatives Nucleophilic Acyl Substitution Reactions

Acid Derivatives and Nucleophilic Acyl Substitution Reactions

Acid anhydride nucleophilic acyl substitution reactions

Acid chlorides nucleophilic acyl substitution reactions

Acid chlorides nucleophilic substitution reactions

Addition reactions nucleophilic aromatic substitution

Alcohols in nucleophilic substitution reactions

Alcohols nucleophilic substitution reactions

Aliphatic carbon, nucleophilic substitution reaction mechanisms

Alkyl halides nucleophilic substitution reactions

Alkyl halides, from nucleophilic substitution reactions

Alkylation Reactions Nucleophilic Substitution

Allylic and Benzylic Halides in Nucleophilic Substitution Reactions

Allylic derivatives nucleophilic substitution, Tsuji-Trost reaction

Amide nucleophilic acyl substitution reactions

Amide nucleophilic substitution reactions

Amination reactions nucleophilic substitution

Amino acids from nucleophilic substitution reactions

Analysis of Several Nucleophilic Substitution Reactions

Anhydrides nucleophilic substitution reactions

Annulation reactions nucleophilic substitution

Anti addition reactions nucleophilic substitution

Anti elimination reactions, nucleophilic substitution

Aromatic compounds, substituted nucleophilic reactions

Aryldiazonium salt nucleophilic substitution reaction

Asymmetric reactions nucleophilic substitution

Asymmetric reactions nucleophilic substitution, allylic derivatives

Benzene Nucleophilic aromatic substitution reactions

Benzylic halides in nucleophilic substitution reactions

Bimolecular nucleophilic substitution reactions stereochemistry

Biological reaction, alcohol nucleophilic acyl substitution

Biological reaction, alcohol nucleophilic substitutions

Borderline reactions, nucleophilic substitution

Borderline reactions, nucleophilic substitution mechanisms

Carbonium ions nucleophilic substitution reactions

Carboxylic Acid Derivatives and Nucleophilic Acyl Substitution Reactions

Carboxylic acid derivatives nucleophilic acyl substitution reactions

Carboxylic acid derivatives nucleophilic substitution reactions

Carboxylic acid nucleophilic acyl substitution reactions

Carboxylic acid nucleophilic substitution reactions

Chloromethane, nucleophilic substitution reaction

Classification of Nucleophilic Substitution Reactions

Concerted reaction bimolecular nucleophilic substitution

Cycloaddition reactions nucleophilic substitution

Diastereomers nucleophilic substitution reactions

Diazonium ions nucleophilic substitution reactions

Dimerization reactions nucleophilic substitution

Dimethyl sulfoxide as solvent in nucleophilic substitution reactions

Domino Reactions Initiated by Nucleophilic Substitution

Electrophilic aromatic substitution reactions arene nucleophiles

Electrophilic reactions nucleophilic substitution

Elimination addition reactions nucleophilic aromatic substitution with

Elimination reactions nucleophilic substitution

Epoxides nucleophilic substitution reactions

Ester nucleophilic acyl substitution reactions

Ester nucleophilic substitution reactions

Esters from nucleophilic substitution reactions

Ethene nucleophilic substitution reactions

Ethers from nucleophilic substitution reaction

Four-coordinate complexes substitution reactions, nucleophilicity

Functional Group Transformation by Nucleophilic Substitution Reactions

Group 16 atoms, nucleophilic substitution alkene-alcohol reactions

Haloalkanes nucleophilic substitution reactions

Halogenated hydrocarbons nucleophilic substitution reactions

Halogenoalkanes, nucleophilic substitution reactions

Haloquinolines, nucleophilic substitution reactions

Hell-Volhard-Zelinskii reaction nucleophilic acyl substitution

Hydrides nucleophilic substitution reactions

Hydrochloric acid nucleophilic substitution reactions

I Reactions of Alkyl Halides Nucleophilic Substitutions and Eliminations

Intramolecular Reactions Nucleophilic Aromatic Substitution

Intramolecular nucleophilic substitution reactions

Introduction to Nucleophilic Substitution Reactions

Kinetically controlled reactions nucleophilic substitution

Labeling reactions nucleophilic substitution

Leaving groups in nucleophilic substitution reactions

Ligand substitution reactions nucleophilic attack

Mechanism of the Nucleophilic Substitution Reaction

Mechanisms of Nucleophilic Substitution Reactions

Microwave irradiation nucleophilic substitution reactions

NUCLEOPHILIC SUBSTITUTION AND ELIMINATION REACTIONS

NUCLEOPHILIC SUBSTITUTION REACTIONS OF HALOALKANES

Neopentyl systems, nucleophilic substitution reactions

Nitrobenzene nucleophilic substitution reactions

Nucleophile olefin combination, aromatic substitution reaction

Nucleophile-substituted carbocation reactions, estimated rate constants

Nucleophiles alkyl halide substitution reactions

Nucleophiles in nucleophilic substitution reactions

Nucleophiles in substitution reactions

Nucleophiles substitution reactions

Nucleophiles substitution reactions

Nucleophilic Acyl Substitution Reactions of Carboxylic Acids

Nucleophilic Aromatic Substitution An Addition-Elimination Reaction

Nucleophilic Substitution Hydrolytic Reactions of Halogenated Alkanes and Alkanoates

Nucleophilic Substitution Reactions Competing Nucleophiles

Nucleophilic Substitution Reactions at the Carboxyl Carbon

Nucleophilic Substitution Reactions at the Saturated C Atom

Nucleophilic Substitution Reactions of Aryldiazonium Salts

Nucleophilic Substitution Reactions of Epoxides

Nucleophilic Substitution Reactions of Ethers

Nucleophilic Substitution Reactions via Meisenheimer Complexes

Nucleophilic Substitution and Addition Reactions

Nucleophilic Substitution of Hydrogen (SNH Reactions)

Nucleophilic acyl substitution reaction acid halides

Nucleophilic acyl substitution reaction biological example

Nucleophilic acyl substitution reaction kinds

Nucleophilic acyl substitution reaction reactivity

Nucleophilic acyl substitution reactions biological

Nucleophilic acyl substitution reactions derivatives

Nucleophilic acyl substitution reactions general reaction

Nucleophilic acyl substitution reactions leaving groups

Nucleophilic acyl substitution reactions of carboxylic acid derivatives

Nucleophilic acyl substitution reactions relative reactivity

Nucleophilic acyl substitution reactions summary

Nucleophilic acyl substitution reactions tetrahedral intermediate

Nucleophilic addition reactions of dienes, acceptor-substituted

Nucleophilic addition reactions of enynes, acceptor-substituted

Nucleophilic addition reactions of polyenes, acceptor-substituted

Nucleophilic additions stereoselective substitution reactions

Nucleophilic aliphatic substitution aziridine reactions

Nucleophilic aliphatic substitution cyclic ether reactions

Nucleophilic and Radicaloid Substitution Reactions

Nucleophilic aromatic substitution halogen exchange reactions

Nucleophilic aromatic substitution organic reaction mechanisms

Nucleophilic aromatic substitution reaction characteristics

Nucleophilic aromatic substitution reactions diazonium ions

Nucleophilic reactions addition, cleavage, substitution, - ring opening

Nucleophilic reactions allylic substitution

Nucleophilic substitution acid-base reaction

Nucleophilic substitution and reduction reactions of amides

Nucleophilic substitution catalytic reactions

Nucleophilic substitution displacement reactions

Nucleophilic substitution formate reactions

Nucleophilic substitution metallation reactions

Nucleophilic substitution process elimination/addition reactions

Nucleophilic substitution process hydrogenation reaction

Nucleophilic substitution reaction aromatic compounds

Nucleophilic substitution reaction biological examples

Nucleophilic substitution reaction intermediate

Nucleophilic substitution reaction summary

Nucleophilic substitution reaction, first-order

Nucleophilic substitution reactions Claisen reaction

Nucleophilic substitution reactions Neutral pyrazoles and indazoles

Nucleophilic substitution reactions Nucleophilicity

Nucleophilic substitution reactions alcohol synthesis

Nucleophilic substitution reactions ambident nucleophiles

Nucleophilic substitution reactions amine formation

Nucleophilic substitution reactions amine synthesis

Nucleophilic substitution reactions aqueous solution

Nucleophilic substitution reactions basicity

Nucleophilic substitution reactions competition among

Nucleophilic substitution reactions competition with elimination

Nucleophilic substitution reactions complexes

Nucleophilic substitution reactions components

Nucleophilic substitution reactions compounds

Nucleophilic substitution reactions described

Nucleophilic substitution reactions dimethyl carbonate

Nucleophilic substitution reactions elucidating mechanisms

Nucleophilic substitution reactions ether synthesis

Nucleophilic substitution reactions ether with strong acid

Nucleophilic substitution reactions examples

Nucleophilic substitution reactions factors determining mechanism

Nucleophilic substitution reactions features

Nucleophilic substitution reactions first-order rate equation

Nucleophilic substitution reactions general features

Nucleophilic substitution reactions general form

Nucleophilic substitution reactions groups

Nucleophilic substitution reactions halides

Nucleophilic substitution reactions in aqueous solution

Nucleophilic substitution reactions leaving groups

Nucleophilic substitution reactions making

Nucleophilic substitution reactions monolayers

Nucleophilic substitution reactions nucleophile strength

Nucleophilic substitution reactions nucleophiles

Nucleophilic substitution reactions nucleophiles

Nucleophilic substitution reactions nucleophilicity, factors affecting

Nucleophilic substitution reactions of acid

Nucleophilic substitution reactions of acid chlorides

Nucleophilic substitution reactions of alcohols

Nucleophilic substitution reactions of alkyl halides

Nucleophilic substitution reactions of carboxylic acids

Nucleophilic substitution reactions of esters

Nucleophilic substitution reactions organic synthesis

Nucleophilic substitution reactions physical properties

Nucleophilic substitution reactions rate-determining step

Nucleophilic substitution reactions second order kinetics

Nucleophilic substitution reactions second-order rate equation

Nucleophilic substitution reactions solvent effects

Nucleophilic substitution reactions stereochemistry

Nucleophilic substitution reactions substrate examples include

Nucleophilic substitution reactions, aliphatic leaving group effects

Nucleophilic substitution reactions, aliphatic steric effects

Nucleophilic substitution reactions, haloalkanes leaving group

Nucleophilic substitution three-component coupling reactions

Nucleophilic substitution type 1 reactions

Nucleophilic substitution umpolung reactions

Nucleophilic substitution, oxazole reactions

Nucleophilic substitutions reactions derivatives

Nucleophilic substitutions substitution reactions

Nucleophilic vinylic substitution reactions

Of nucleophilic substitution reactions

Organic chemistry nucleophilic substitution reaction

Organic reaction mechanisms nucleophilic substitution reactions

Organometallic nucleophiles substitution reactions with

Organosilanes nucleophilic substitution reactions

Organosilicon compounds nucleophilic substitution reactions

Other Nucleophilic Substitution Reactions

Oxygen nucleophiles substitution reactions

Palladium-Catalyzed Substitution Reactions of Allylic, Propargylic, and Related Electrophiles with Heteroatom Nucleophiles

Phosphoramidite nucleophilic substitution reactions

Photochemical reactions aromatic nucleophilic substitution

Photoinduced radical reactions nucleophilic aromatic substitution

Polyaniline nucleophilic substitution reaction

Preassociation reactions, nucleophilic substitution

Propargylic Substitution Reactions with Carbon-Centered Nucleophiles

Propargylic Substitution Reactions with Heteroatom-Centered Nucleophiles

Properties and Reactions of Haloalkanes Bimolecular Nucleophilic Substitution

Pyridines 2-halo, nucleophilic substitution reactions

Reaction Paths for Nucleophilic Substitution (SN2) Reactions

Reaction mechanisms nucleophilic acyl substitution

Reaction mechanisms nucleophilic aromatic substitution

Reaction mechanisms nucleophilic substitution reactions

Reaction rate nucleophilic substitution reactions

Reactions of Alkyl Halides Nucleophilic Substitutions and Eliminations

Reactions of Arenes Electrophilic and Nucleophilic Aromatic Substitution

Reactions of Carboxylic Acids and Derivatives Nucleophilic Acyl Substitution

Reactions of Nucleophilic Substitutions and Eliminations

Reactions with Nucleophiles giving Substitution Products

Related Nucleophilic Aromatic Substitution Reactions

Representative nucleophilic substitution reactions

SNAr reaction nucleophilic aromatic substitution

Simulations of Nucleophilic Substitution Reactions

Sn2 nucleophilic substitution reaction

Solvent effects, reaction coordinates, and reorganization energies on nucleophilic substitution

Solvent effects, reaction coordinates, and reorganization energies on nucleophilic substitution reactions in aqueous solution

Some synthetically important nucleophilic substitution reactions

Square-planar substitution reactions nucleophilic ligand

Stepwise nucleophilic substitution concerted reactions

Stereochemical course of nucleophilic substitution reactions

Stereochemistry of nucleophilic substitution reactions

Stereospecific reactions bimolecular nucleophilic substitution

Substitution Reactions (mostly Nucleophilic)

Substitution Reactions with Nucleophilic Reagents

Substitution reactions aliphatic nucleophilic: examples illustrating

Substitution reactions aromatic nucleophilic (addition-elimination

Substitution reactions nucleophilic

Substitution reactions nucleophilic

Substitution reactions nucleophilic acyl

Substitution reactions nucleophilic aliphatic

Substitution reactions nucleophilic aromatic

Substitution reactions nucleophilic, bimolecular

Substitution reactions nucleophilic, unimolecular

Substitution reactions prochiral nucleophiles

Substitution reactions, inhibition nucleophilic

Substitution reactions, nucleophilic active electrons

Substitution, nucleophilic reaction mechanism

Substitution, radical nucleophilic, unimolecular reactions

Sulfonate esters nucleophilic substitution reactions

Sulfur nucleophiles substitution reactions

Sulphones nucleophilic substitution reactions

Sulphoxides nucleophilic substitution reactions

Summary of Nucleophilic Acyl Substitution Reactions

Synthetic reactions nucleophilic substitution

The Discovery of Nucleophilic Substitution Reactions

The Sn2 reaction bimolecular nucleophilic substitution

Thioethers, from nucleophilic substitution reactions

Tsuji-Trost reaction nucleophilic substitution

Using acetylenic reactivity nucleophilic substitution with metal acetylides and related reactions

Vicarious nucleophilic substitution reactions

What Are the Products of Nucleophilic Aliphatic Substitution Reactions

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