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Resistance streptomycin

Figure 12.8. Transformation activity (streptomycin resistance) of a DNA-yeast extract mixture as a function of illumination time. (Reproduced with permission from Ref. 74.)... Figure 12.8. Transformation activity (streptomycin resistance) of a DNA-yeast extract mixture as a function of illumination time. (Reproduced with permission from Ref. 74.)...
Bacillus subtilis transformants were identified by their resistance to naphthalene, parachlorobiphenyl, or dibenzofuran. Controls subtilis protoplasts regenerated without the addition of B. megaterium plasmid DNA) exhibited no increased reistance to these three compounds. That each transformant was B. subtilis and not a contaminant was verified by testing for the B. subtilis chromosomal markers. Only streptomycin resistant strains that showed arginine and leucine dependent growth were used in subsequent experiments. [Pg.334]

Apramycin is unapproved for use in the USA for food animals but in many European countries it is widely used for the same indications as neomycin. Apramycin is effective vitro against neomycin- and streptomycin-resistant Gram-negative bacteria associated with diseases of new born calves. [Pg.19]

Tomato canker caused by Xanthomonas can be controlled by the application of tetracycline(52-53). Streptomycin resistant strains of bacteria have Been found on peach, tomato and peppers(54), and the mixture of two antibiotics has helped to stop tHe build-up of resistance in the patho -gens in some cases(55-56). The silvery disease of sugar-beet caused by Coryn 5actferium is insufficiently controlled by mercurial compounds, but is completely eliminated when seeds are dipped for several hours in a solution of streptomycin. [Pg.52]

Many applications of the aminoglycosides have been of historical significance in genetics and microbiology. For example, mutations to streptomycin resistance were employed as counterselective genetic markers in the historic experiments of William Hayes that demonstrated the existence of bacterial conjugation and the requirement of donor (Hfr or F-b) and receptor (F—) species. ... [Pg.3]

Here again I should like to backtrack to 1951. At that time resistcuit orgcuiisms except for streptomycin-resistant tubercle bacilli had not yet appeared and the chemotherapy of bacterial diseases seemed to be almost completed. Therefore, I endeavored to extend antibiotic research to a new area and initiated the screening of antitumor antibiotics. I reported the discovery of two microbial products, svibstance No. 289 and sarkonycin (67). [Pg.77]

It is used in the treatment of tuberculosis caused by streptomycin resistant strains but since agents with lesser toxicity e.g. capreomycin and amikacin are available, its use is obsolete. [Pg.368]

Strains of multidrug-resistant Mycobacterium tuberculosis, including streptomycin-resistant strains, are usually susceptible to amikacin. Kanamycin-resistant strains may be cross-resistant to amikacin. The dosage of amikacin for tuberculosis is... [Pg.1026]

The aminoglycoside antibiotics are discussed in Chapter 45. Kanamycin has been used for treatment of tuberculosis caused by streptomycin-resistant strains, but the availability of less toxic alternatives (eg, capreomycin and amikacin) has rendered it obsolete. [Pg.1049]

VC-proficient and -deficient strains of Escherichia coli. It induced streptomycin-resistant... [Pg.631]

Streptomycin is given intramuscularly. It exerts its effects only on extracellular tubercle bacilli. When combined with other drugs, it delays the emergence of streptomycin-resistant mutants. It is ototoxic and may cause deafness. [Pg.384]

Ethambutol suppresses the growth of isoniazid- and streptomycin-resistant tubercle bacilli. The most important but not common side effects are optic neuritis, decreased visual acuity, and inability to perceive the color green. [Pg.384]

Although one of the first assays for mutagenicity was a forward mutation to streptomycin resistance in E. coli, forward-mutation assays in bacteria have not been used as extensively as reverse-mutation assays. A forward-mutation assay should detect a wider range of mutagens than the presumably more restrictive reverse-mutation assays, but, in practice, there is little evidence to support this expectation. [Pg.87]

The drugs used to treat TB include capreomycin, cycloserine, ethambutol, isoniazid, pyrazinamide, rifabutin, rifampicin and streptomycin. Resistance is most likely with long courses of treatment of antimicrobial agents and treatment courses are six (or even nine) months long. [Pg.352]

The major streptomycin resistance determinant, aphD, encoding streptomycin-6-phosphotransferase is encoded just downstream of strR and cotranscribed with strR by read-through from the AdpA-dependent strR promoter.47 The cotranscription of strR and aphD accounts for the prompt induction of streptomycin resistance by A-factor and achieves a rapid increase in self-resistance just before induction of streptomycin biosynthesis. [Pg.295]

Fig. 5. Secondary structure of the E. coli 16S rRNA region involved in streptomycin sensitivity. The encircled C at position 912 is mutated to U in streptomycin-resistant chloroplast ribosomes and in archaeal ribosomes, with the exception of those of Desulfuwcoccus mobilis. Fig. 5. Secondary structure of the E. coli 16S rRNA region involved in streptomycin sensitivity. The encircled C at position 912 is mutated to U in streptomycin-resistant chloroplast ribosomes and in archaeal ribosomes, with the exception of those of Desulfuwcoccus mobilis.
Resistance to streptomycin Resistance to other aminoglycoside antibiotics Enzymatic resistance... [Pg.334]

Interaction between -lactamase and intrinsic resistance Resistance to aminoglycosides Resistance to kanamycins Resistance to neomycins Resistance to streptomycin Resistance to gentamicin Resistance to lividomycin Resistance to tobramycin Resistance to BB-K8 Resistance to chloramphenicoi... [Pg.334]

Resistance to streptomycin. Resistance to streptomycin has been characterised as a mutation affecting the 30 S ribosome subunit [159] and studies have shown that streptomycin resistance is the result of a single amino acid change in a protein (S12) of the small subunit [160]. [Pg.358]

The ribosomes of streptomycin-resistant mutants that have been analysed do not bind to streptomycin [161,162]. The alteration in the 30 S protein S12 is sufficient to prevent binding of the drug. At least two other proteins are involved in the binding of streptomycin to ribosomes [163] and it might be expected that resistant mutants with alterations in these other proteins might be found but none have been reported at the present time. [Pg.358]

Some clinical isolates of streptomycin resistant strains of Ps. aeruginosa have been reported to contain no streptomycin inactivating enzymes [164]. Such strains may have altered ribosomes but no detailed studies on the protein synthetic system of these organisms have been carried out. [Pg.358]

Extrachromosomally mediated streptomycin resistance has been reported by many workers (see p. 386). Pseudomonas strains transferring streptomycin resistance transferred to the recipient strain the ability to produce phosphorylating enzyme [210]. [Pg.377]

Ethambutol is tuberculostatic and acts against Mycobacterium tuberculosis and Mycobacterium kansasii as well as some strains of Mycobacterium avium complex. It has no effect on other bacteria. The sensitivities of non-tuberculous mycobacteria are variable. Ethambutol suppresses the growth of most isoniazid-resistant and streptomycin-resistant tubercle bacilli (1). [Pg.1282]

Variations of the Structure of Natural Cord-factor in Different Strains. —It is known that different strains frequently contain a different assortment of mycolic acids. Thus, it is not astonishing that cord factor of different strains sometimes contains different mycolic acids. It was found that cord factor of a streptomycin-resistant strain of H37-Rv and of the BCG strain contains a methoxyl-free 3, x-dihydroxymycolanoic acid C87H174O4 5 CHj, whereas the virulent, human strain Br vannes contains a cord factor wherein the mycolic acid is a 3-hydroxy-x-methoxy-mycolanoic acid C88H176O4 5 CH2. [Pg.218]


See other pages where Resistance streptomycin is mentioned: [Pg.1087]    [Pg.591]    [Pg.340]    [Pg.183]    [Pg.335]    [Pg.332]    [Pg.332]    [Pg.4]    [Pg.123]    [Pg.562]    [Pg.19]    [Pg.1048]    [Pg.1050]    [Pg.1485]    [Pg.1690]    [Pg.1691]    [Pg.1710]    [Pg.756]    [Pg.1096]    [Pg.1099]    [Pg.354]    [Pg.611]    [Pg.494]    [Pg.1087]    [Pg.1360]    [Pg.342]   
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See also in sourсe #XX -- [ Pg.545 , Pg.547 ]

See also in sourсe #XX -- [ Pg.199 , Pg.200 , Pg.278 ]




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Streptomycin

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