Water for injection sterile

Sterile water for injection is used mosdy for the solution or suspension of dmgs just before injection. In containers of 30-mL capacity or less, it may contain a bacteriostatic agent. Inclusion of such agents in larger volumes can cause toxicity. 

Clinical Use. Vancomycin and teicoplanin as fomiulated dmgs are lyophilized powders to be reconstituted with sterile water for injection. Vancomycin hydrochloride [1404-93-9] is presented in vials of 500 mg that give 100—200 mL solution of pH 2.5—4.2. It is administered by slow (60 min) infusion at a dose of 500 mg every 6 h or 1 g every 12 h/d. The teicoplanin contains the five factors (87%) plus 13% of the pseudoaglycone T-A3-1. It is presented in vials containing 200 mg of lyophili ed power that after dissolution with 3 mL of solvent gives a solution at pH 7.5. The dose regimen is 200—800 mg/d by iv bolus adrninistration. 

Methicillin sodium To reconstitute 1 g vial add 1.5 mL of sterile water for injection or sodium chloride injection. Each reconstituted mL contains approximately 500 mg of methicillin. 

Several guidelines are available in the literature for the pharmacist who must extemporaneously prepare an ophthalmic solution. The USP contains a section on ophthalmic solutions, as do other compendia and several standard textbooks. Since the pharmacist does not have the facilities to test the product, he or she should dispense only small quantities, with an expiration date of no more than 30 days. Refrigeration of the product should also be required as a precautionary measure. To reduce the largest potential source of microbial contamination, only sterile purified water should be used in compounding ophthalmic solutions. Sterile water for injection, USP, from unopened IV bottles or vials is the highest-quality water available to the pharmacist. Prepackaged sterile water with bacteriostatic agents should not be used. 

FDA approved intraocular injections include mio-tics, viscoelastics, and viscoadherents and an antiviral agent for intravitreal injection. The approved intraocular miotics, carbachol (Miostat ) and acetylcholine (Miochol ), are injected into the anterior chamber at the end of cataract surgery to constrict the pupil and allow the iris to cover the implanted intraocular lens. Carbachol is formulated in a BSS vehicle in sterile water for injection at a physiological pH... 

Sterile water for injection and irrigation (excl pour bottles) in containers of 100 ml or more. 

Certain medications including penicillins and other antibiotics are unstable when stored in solution form and are therefore packaged in powder form. The dry powders must be reconstituted with a sterile diluent such as sterile water for injection or sterile sodium chloride (normal saline) solution. Instructions supplied with the vial state the volume of diluent which should be added. The resulting volume of the reconstituted drug and the approximate average concentration per milliliter are provided in the label or the package information sheet (package insert). 

A vial contains 1 g of Ancef (cefazolin sodium). Express the concentrations of cefazolin sodium, in milligrams per milliliter, following reconstitution with sterile water for injection to the following volumes ... 

A 25 mL vial of NaCl solution was diluted to a liter with sterile water for injection. The concentration (w/v) of the NaCl in the finished product was 0.9%. What was the concentration in terms of mEq/mL, of the original solution ... 

How many milliliters of sterile water for injection must be added to a liter of a 50% w/v dextrose injection to reduce the concentration to 10%... 

PEG-Intron PEG-Intron is used for the treatment of hepatitis C. The product consists of a covalent conjugate of the recombinant interferon- -2b with monomethoxy polyethylene glycol (PEG) supplied in vials with 74/rg, 118.4/rg, 177.6/rg, or 222/rg of the active ingredient and 1.11 mg sodium phosphate (dibasic,anhydrous),l.ll mg sodium phosphate (monobasic, dihydrate), 59.2 mg sucrose, and 0.074mg polysorbate 80. The powder is reconstituted with sterile water-for-injection. 

Depyrogenation methods used by compounding pharmaeists inelude dry heat and rinsing with Sterile Water for Injection, USP. 

Sterile water for injection, USP (Abbott Laboratories, North Chicago, IL). Polypropylene, 50-mL sterile, conical centrifuge tubes (Becton Dickinson Labware, Lincoln Park, NJ). 

Resuspend the pellet in 3 mL of sterile water for injection, and gently mix (by inversion) the cell suspension for 20 s. Then add 1 mL of 3.5% NaCl to make the solution isotonic. Centrifuge at 500g for 7 min to pellet the cells. 

Sterile water for injection, USP (Abbott Laboratories, North Chicago, IL). 

Treprostinil can be administered as supplied or diluted for IV infusion with sterile water for injection or 0.9% sodium chloride injection prior to administration. 

Admixture compatibility- Digoxin injection can be administered undiluted or diluted with a 4-fold or greater volume of sterile water for injection, 0.9% sodium chloride injection, or 5% dextrose injection. The use of less than 4-fold volume of diluent could lead to precipitation of the digoxin. Immediate use of the diluted product is recommended. 

Continued nebuiization Continued nebulization of acetylcysteine with a dry gas results in concentration of drug in the nebulizer due to evaporation. Extreme concentration may impede nebulization and drug delivery. Dilute with Sterile Water for Injection as concentration occurs. 

Preparation for administration - Dissolve the contents of the vial using 2.1 ml sterile water for injection to provide a solution containing approximately olanzapine 5 mg/mL. The resulting solution should appear clear and yellow. 

Antlspasmodic 2 to 3 mg/kg/day divided every 4 to 6 hours and at bedtime. SCOPOLAMINE HBr (Hyoscine HBr) Give subcutaneously or IM may give IV after dilution with Sterile Water for Injection. 

IM administration Reconstitute cefepime with the following diluents Sterile Water for Injection, 0.9% Sodium Chloride, 5% Dextrose Injection, 0.5% or 1 % lidocaine hydrochloride, or Sterile Bacteriostatic Water for Injection with parabens or benzyl alcohol. 

Do not add additives or other medications to IV moxifloxacin or infuse simultaneously through the same IV line. If the same IV line is used for sequential infusion of other drugs, or if the piggyback method of administration is used, flush the line before and after infusion of moxifloxacin IV with a compatible solution. Moxifloxacin IV is compatible with the following IV solutions at ratios from 1 10 to 10 1 0.9% sodium chloride injection, IM sodium chloride injection, 5% dextrose injection, sterile water for injection, 10% dextrose for injection, Lactated Ringer s for injection. 

Reconstitution - Reconstitute drug with a minimum of 75 mL sterile water for injection or inhalation in the original 100 mL vial. Shake well. Transfer to the clean, sterilized 500 mL SPAG-2 reservoir and further dilute to a final volume of 300 mL with sterile water for injection or inhalation. The final concentration should be 20 mg/mL. 

Preparation for administration Enfuvirtide must only be reconstituted with 1.1 ml of sterile water for injection. 

IM- Dissolve the contents of 1 vial in 3 mL of Sterile Water for Injection. 

IV- Dissolve the contents of 1 vial in 3 to 5 mL of Sterile Water for Injection or 5% Dextrose Injection. Further dilute the calculated dose in 50 to 250 mL of 5% Dextrose solution. 

Reconstitution-The contents of 1 vial must be dissolved in 6 mL Sterile Water for Injection, LISP. It is important to use only sterile water saline solution will cause the drug to precipitate. Place the entire reconstituted contents of the vial into the Respirgard II nebulizer reservoir for administration. Do not mix the pentamidine solution with any other drugs. 

Organophosphate poisoning IV l 2g initially in 100 ml 0.9 NaCl infused over 15-30 minutes or 5% solution in sterile water for injection over not less than 5 minutes. Repeat l-2gin 1 hr if muscle weakness persists. 

Dosage form Leukine is formulated as a sterile, preserved, injectable solution (500pg/l) in a 1ml vial. Lyophilized Leukine is a sterile, preservative-free powder (250 pg) that requires reconstitution with sterile water for injection or bacteriostatic water for injection. 

Dosage form Neumega is available for injection in single-use vials containing 5 mg of oprelvekin as a sterile lyophilized powder. It is reconstituted by the addition of sterile water for injection. 

Dosage form BeneFix is formulated as a sterile nonpyrogenic, lyophilized preparation, intended for injection after reconstitution with sterile water for injection. It is available in single-use vials containing the labeled amount of factor IX activity, expressed in international units (lU). Each vial contains nominally 250,500, or 1000 lU of Coagulation Factor IX (Recombinant). 

Route of administration NovoSeven is intended for intravenous bolus administration only, after reconstitution with the appropriate volume of sterile water for injection. 

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