Organophosphates poisoning

Diagnosis of organophosphate poisoning (including methyl parathion) can be confirmed by evaluation of serum (plasma) cholinesterase and erythrocyte cholinesterase. However, cholinesterase inhibition is not specific for organophosphates. For example, carbamate insecticides also result in cholinesterase inhibition, which is usually transitory. Erythrocyte cholinesterase measurement is a specific test for... [Pg.113]

A classification of organophosphate poisoning has been proposed by Tafuri and Roberts (1987) modified from Namba et al. (1971). Clinical signs and symptoms of intoxication may occur when serum cholinesterase levels drop to below 50% of the normal value. Mild poisoning, with the patient still ambulatory, may occur when serum cholinesterase levels are 20-50% of normal moderate poisoning with inability to walk with levels 10-20% of normal and severe poisoning with respiratory distress and unconsciousness with serum cholinesterase levels <10% of normal. [Pg.114]

De Bleecker JL. 1992. Transient opsoclonus in organophosphate poisoning. Acta Neurol Scand 86 529-531. [Pg.200]

Lotti M, Becker CE. 1982. Treatment of acute organophosphate poisoning Evidence of a direct effect on central nervous system by 2-PAM (pyridine-2-aldoxime methyl chloride). J Toxicol Clin Toxicol 19 121-127. [Pg.220]

Midtling JE, Barnett PG, Coye MJ, et al. 1985. Clinical management of field worker organophosphate poisoning. West Med 142 514-518. [Pg.222]

Use of the muscle relaxant succinylcholine, which is metabolized by plasma cholinesterase, is contraindicated in cases of organophosphate poisoning (Giurini et al. 1986). [Pg.233]

MintonNA, Murray VSG. 1988. A review of organophosphate poisoning. Med Toxicol 3 350-375. [Pg.345]

Gordon JJ, Leadbeater L, Maidment MP. The protection of animals against organophosphate poisoning by pretreatment with a carbamate. Toxicol. Appl. Pharmacol. 43 207-216, 1978. [Pg.120]

Watson M Jr, Benson WW Jr, Gabica J Jr. 1971. Accidental organophosphate poisoning in cattle, two case histories. Arch Environ Health 22 582-583. [Pg.199]

Merrill DG, Mihm EG Prolonged toxicity of organophosphate poisoning. Grit Care Med 10 5 50-551, 1982... [Pg.340]

Coye MJ, Barnett PG, Midtling JE, et ah Clinical confirmation of organophosphate poisoning of agricultural workers. Am J Ind Med 10 399-409, 1986... [Pg.497]

Milhy TH Prevention and management of organophosphate poisoning. JAMA 216 2131-2133, 1971... [Pg.553]

SLE systemic lupus erythematosus SLUDGE mnemonic for organophosphate poisoning... [Pg.1]

Martinez-Chuecos J, Del Carmen JM, Gimenez MP, Martinez D, Menendez M. Experience with hemoperfu-sion for organophosphate poisoning. Crit Care Med 1992 20(ll) 1538-43. [Pg.285]

Buckley NA, Eddleston M, Szinicz L. Oximes for acute organophosphate poisoning. Cochrane Database Syst Rev 2005. Issue 1. Art. No. CD005085. DOI 10.1002/14651858.CD005085. [Pg.517]

Organophosphate poisoning IV l 2g initially in 100 ml 0.9 NaCl infused over 15-30 minutes or 5% solution in sterile water for injection over not less than 5 minutes. Repeat l-2gin 1 hr if muscle weakness persists. [Pg.1011]

Receptor interactions were seen at nicotinic and muscarinic receptors. No correlations were found, however, between atropinelike or curare-like actions of these compounds and their protective effects against organophosphate poisoning. [Pg.28]

Warriner, R.A., III, Nies, A.S., and Hayes, W.J., Jr. Severe organophosphate poisoning complicated by alcohol and turpentine ingestion. Arch. Environ. Health 32 203-205, 1977... [Pg.45]

Davies, D.R., Green, A.L., and Willey, G.L. 2-Hydroxy-iminomethyl-N-methylpyridlnium methanesulphonate and atropine in the treatment of severe organophosphate poisoning. Br. J. Pharmacol. Chemother. 14 5-8, 1959. [Pg.340]

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